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View article: Protective immunity induced by Tp0136 epitope vaccines with mRNA LNP or protein delivery
Protective immunity induced by Tp0136 epitope vaccines with mRNA LNP or protein delivery Open
Syphilis, caused by Treponema pallidum, remains a major global health burden. Given the key role of T cell-mediated immunity in T. pallidum clearance, this study evaluates a Tp0136-derived T-cell epitope (Tp0136T1) delivered via two platfo…
View article: Effects of Root Exudates on Seed Germination and Seedling Growth of Wolfberry (Lycium barbarum L.) and the Development of Root Rot Diseases
Effects of Root Exudates on Seed Germination and Seedling Growth of Wolfberry (Lycium barbarum L.) and the Development of Root Rot Diseases Open
Root exudates play a critical role in enabling plants to respond to environmental stresses and mediate information exchange within the rhizosphere. These compounds regulate plant–rhizosphere interactions and significantly influence the str…
View article: Host cell KRT-18 as a non-redox dependent interactor of Cryptosporidium parvum PDI enables parasite infection
Host cell KRT-18 as a non-redox dependent interactor of Cryptosporidium parvum PDI enables parasite infection Open
The protein disulfide isomerase (PDI) is a conserved redox protein that plays an essential role during host cell adhesion and invasion in apicomplexan parasites. PDI is also expressed in Cryptosporidium parvum, but its role remains unknown…
View article: Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes
Data-driven subtypes of polycystic ovary syndrome and their association with clinical outcomes Open
Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder that affects 11%-13% of women worldwide, with profound implications for fertility and long-term metabolic health. Here we identify four reproducible subtypes…
View article: MiR-125b-5p targets Bak1 to regulate HCT-8 cell apoptosis in response to Cryptosporidium parvum infection via mitochondrial pathway
MiR-125b-5p targets Bak1 to regulate HCT-8 cell apoptosis in response to Cryptosporidium parvum infection via mitochondrial pathway Open
Background Cryptosporidium parvum infection can regulate apoptosis of host epithelial cells through both extrinsic and intrinsic apoptotic pathways, potentially involving various microRNAs (miRNAs). This study focuses on the role of miR-12…
View article: Secretome and Transcriptome Analyses Reveal New Potential Virulence Factors during <i>Cryptosporidium parvum</i> Invasion
Secretome and Transcriptome Analyses Reveal New Potential Virulence Factors during <i>Cryptosporidium parvum</i> Invasion Open
Cryptosporidium parvum is a major cause of life-threatening diarrheal disease in young children and immunocompromised individuals. During the initial infection, C. parvum secretes a large number of virulence proteins that help the parasite…
View article: Comparison of the safety and efficacy of moderately hypofractionated and conventionally fractionated radiotherapy for localized prostate cancer: evidence from 9074 men in 13 randomized clinical trials
Comparison of the safety and efficacy of moderately hypofractionated and conventionally fractionated radiotherapy for localized prostate cancer: evidence from 9074 men in 13 randomized clinical trials Open
The clinical outcomes of HFRT and CFRT were comparable, with similar five-year relapse-free survival, and without different risks of acute or late, severe GI or GU toxicity. HFRT treatment may increase the risk of Grade 2 or worse acute GI…
View article: Overexpression of the Lipid Transfer Protein Gene SpLTP1 from Desert Pioneer Plant Stipagrostis pennata Enhances the Drought Tolerance in Arabidopsis
Overexpression of the Lipid Transfer Protein Gene SpLTP1 from Desert Pioneer Plant Stipagrostis pennata Enhances the Drought Tolerance in Arabidopsis Open
Lipid transfer proteins (LTPs) play crucial regulatory roles in plant growth, development, and abiotic stress responses. Stipagrostis pennata is a species of grass widely distributed in arid and semi-arid regions, particularly adapted to d…
View article: Add-on ketogenic diet versus antiseizure medications alone in children with developmental and epileptic encephalopathies: a prospective comparative cohort study
Add-on ketogenic diet versus antiseizure medications alone in children with developmental and epileptic encephalopathies: a prospective comparative cohort study Open
Objective To compare the effectiveness and safety of ketogenic diet (KD) versus antiseizure medications (ASMs) adjustment in developmental and epileptic encephalopathy (DEE). Methods In this prospective, single-center cohort study, 268 par…
View article: FITrig: A High-Performance Detection Technique for Efficient Ultra-Long-Period Pulsars
FITrig: A High-Performance Detection Technique for Efficient Ultra-Long-Period Pulsars Open
Ultra-long-period (ULP) pulsars, a newly identified class of celestial transients, offer unique insights into astrophysics, though very few have been detected to date. In radio astronomy, most time-domain detection methods cannot find thes…
View article: Radiological frontiers in understanding paraspinal muscle pathophysiology in chronic low back pain
Radiological frontiers in understanding paraspinal muscle pathophysiology in chronic low back pain Open
Background Paraspinal muscles have a profound role in maintaining spinal stability and are often implicated in spinal degenerative conditions as well as chronic low back pain (CLBP). Alterations in these muscles have significant clinical i…
View article: Effect of Nano-Selenium on Intestinal Oxidative Stress Induced by H2O2 in Mice
Effect of Nano-Selenium on Intestinal Oxidative Stress Induced by H2O2 in Mice Open
Selenium is an important trace element with certain antioxidant effects. Nano-selenium, as a novel selenium source, has the advantages of strong biological activity, high absorption efficiency, and low toxicity. The aim of the present stud…
View article: RETRACTED: Serplulimab combined with gemcitabine, nab-paclitaxel, and stereotactic body radiotherapy as first-line treatment for metastatic pancreatic adenocarcinoma: a multicentre, single-arm, phase II trial
RETRACTED: Serplulimab combined with gemcitabine, nab-paclitaxel, and stereotactic body radiotherapy as first-line treatment for metastatic pancreatic adenocarcinoma: a multicentre, single-arm, phase II trial Open
The authors have requested that this preprint be removed from Research Square.
View article: [Total 3D laparoscopic ileal ureters replacement for bilateral ureters combined with bladder augmentation in the management of post-radiotherapy bilateral ureteral strictures and contracted bladder].
[Total 3D laparoscopic ileal ureters replacement for bilateral ureters combined with bladder augmentation in the management of post-radiotherapy bilateral ureteral strictures and contracted bladder]. Open
Membrane anatomy-based dissection facilitates safe mobilization of fibrotic ureters with minimal bleeding and collateral damage. Total intracorporeal 3D laparoscopic ileal ureters replacement for bilateral ureters combined with bladder aug…
View article: CAR Cell-Derived Exosomes in Cancer Therapy: Biogenesis, Engineering Strategies and Antitumor Mechanisms
CAR Cell-Derived Exosomes in Cancer Therapy: Biogenesis, Engineering Strategies and Antitumor Mechanisms Open
Chimeric antigen receptor (CAR) cell therapy, encompassing CAR T, CAR NK, and CAR macrophage cells, demonstrates high efficacy in tumor treatment, conferring durable and effective responses, notably in hematologic malignancies. However, ch…
View article: Role and mechanism of Integrin α5β1 in bone formation and disease
Role and mechanism of Integrin α5β1 in bone formation and disease Open
Integrin α5β1 is a key signaling protein between cells and the extracellular matrix. It plays crucial roles in biological processes such as cell adhesion, migration, and differentiation. Recent studies have shown that integrin α5β1 is sign…
View article: Can working in agriculture have a favorable effect on depressive symptoms? Life satisfaction as a mediator
Can working in agriculture have a favorable effect on depressive symptoms? Life satisfaction as a mediator Open
Purpose Several studies have explored the relationship between various aspects of work and the onset of depressive symptoms. However, there is a lack of research focusing on the association between job types and depressive symptoms. This s…
View article: Cardiometabolic index is a novel predictor for osteoporosis in type 2 diabetes mellitus patients with MAFLD: a cross-sectional study
Cardiometabolic index is a novel predictor for osteoporosis in type 2 diabetes mellitus patients with MAFLD: a cross-sectional study Open
CMI shows a significant negative correlation with BMD in T2DM patients with MAFLD. It is an independent risk factor for OP in this patient population, offering a new direction for the prevention and screening of OP in individuals with T2DM…
View article: Retroperitoneal invasive fibromatosis after laparoscopic radical resection of colon cancer: a case report and literature review
Retroperitoneal invasive fibromatosis after laparoscopic radical resection of colon cancer: a case report and literature review Open
Invasive fibromatosis is a rare, locally invasive, benign fibrous tumor that mainly occurs in the anterior abdominal wall and limbs, with a lower incidence in the retroperitoneum. This article reports a case of retroperitoneal invasive fib…
View article: Overexpression of the β-Glucosidase Gene SpBGLU25 from the Desert Pioneer Plant Stipagrostis pennata Enhances the Drought Tolerance in Arabidopsis
Overexpression of the β-Glucosidase Gene SpBGLU25 from the Desert Pioneer Plant Stipagrostis pennata Enhances the Drought Tolerance in Arabidopsis Open
This research centers on the sand-fixing plant known as Stipagrostis pennata, from which the β-glucosidase gene SpBGLU25 was successfully cloned using the molecular cloning method. SpBGLU25 encodes a hydrophilic and stable protein made up …