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View article: RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells
RPL5 deficiency-induced ribosomal stress targets a select subset of proteins and inhibits the PI3K-Akt-mTOR signaling pathway to eradicate leukemia stem cells Open
Ribosomal protein L5 (RPL5) is considered a haplo-insufficient tumor suppressor by upregulating p53 expression or promoting the inactivation of c-Myc in solid tumors upon tumor initiation. However, its detailed effect and mechanism in tumo…
View article: Clinical Study on the Treatment of Somatisation Disorder With Repetitive Transcranial Magnetic Stimulation Combined With Venlafaxine
Clinical Study on the Treatment of Somatisation Disorder With Repetitive Transcranial Magnetic Stimulation Combined With Venlafaxine Open
Background: Somatisation disorder (SD) is a chronic and complex mental health condition characterized by persistent somatic symptoms lacking a clear organic basis, frequently co-occurring with anxiety and depressive disorders. Venlafaxine,…
View article: A disproportionality analysis of FDA adverse event reporting system (FAERS) events for filgotinib
A disproportionality analysis of FDA adverse event reporting system (FAERS) events for filgotinib Open
Background Although filgotinib, a selective Janus kinase 1 inhibitor, has been increasingly applied in the treatment of inflammatory diseases, its comprehensive safety profile remains insufficiently characterized. Using data from the FAERS…
View article: Predicting Ki-67 expression levels in non-small cell lung cancer using an explainable CT-based deep learning radiomics model
Predicting Ki-67 expression levels in non-small cell lung cancer using an explainable CT-based deep learning radiomics model Open
Objective To predict Ki-67 expression levels in non-small cell lung cancer (NSCLC) using an interpretable model combining clinical-radiological, radiomic, and deep learning features. Methods This retrospective study included 259 NSCLC pati…
View article: Evaluation of Sex-Stratified Polygenic Risk Scores for Type 2 Diabetes Mellitus and Glycemic Traits in the Framingham Heart Study
Evaluation of Sex-Stratified Polygenic Risk Scores for Type 2 Diabetes Mellitus and Glycemic Traits in the Framingham Heart Study Open
These results highlight the need for larger sex-stratified studies and the optimization of sex-stratified risk models for clinical practice.
View article: Genome-wide comprehensive analysis the molecular phylogenetic evolution, functional divergence and tissue-specific expression of GH3 gene family in Salvia miltiorrhiza, Arabidopsis thaliana, and Oryza sativa
Genome-wide comprehensive analysis the molecular phylogenetic evolution, functional divergence and tissue-specific expression of GH3 gene family in Salvia miltiorrhiza, Arabidopsis thaliana, and Oryza sativa Open
Auxin, as a central phytohormone and signaling molecule, plays a crucial role in plant growth and development. The activity of auxin is tightly regulated by the auxin-responsive GH3 gene family. In this study, a total of 40 GH3 genes in A.…
View article: Herbal treatment of IBV–E. coli salpingitis establishment of a salpingitis model of layer chickens caused by co-infection of infectious bronchitis virus and Escherichia coli for the curative efficacy assessment of three Chinese herbal compounds
Herbal treatment of IBV–E. coli salpingitis establishment of a salpingitis model of layer chickens caused by co-infection of infectious bronchitis virus and Escherichia coli for the curative efficacy assessment of three Chinese herbal compounds Open
Salpingitis is a common disease affecting production performance of layer chickens, with pathogenic microbial infections being one of the primary etiological factors. Clinically, Infectious bronchitis virus (IBV) and Escherichia coli (E. c…
View article: Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data.
Accelerating Medicines Partnership in Type 2 Diabetes and Common Metabolic Diseases: Collaborating to Maximize the Value of Genetic and Genomic Data. Open
In the last two decades, significant progress has been made toward understanding the genetic basis of type 2 diabetes. An important supporter of this research has been the National Institute of Diabetes and Digestive and Kidney Diseases (N…
View article: Mid- and long-term evaluation of an alternative to the Liu' modified Bentall procedure for aortic root aneurysm
Mid- and long-term evaluation of an alternative to the Liu' modified Bentall procedure for aortic root aneurysm Open
Background Due to complications such as aortic root bleeding and high coronary tension with the conventional Bentall technique to treat aortic root aneurysms, new methods have been developed to enhance patient outcomes. This study aimed to…
View article: Targeting estrogen receptor potentiates responsiveness to PD-1 blockade by inducing HMGB1 SUMOylation 3304
Targeting estrogen receptor potentiates responsiveness to PD-1 blockade by inducing HMGB1 SUMOylation 3304 Open
Description Cold tumors, typically lacking infiltrating lymphocytes, are resistant to immune checkpoint inhibitors (ICIs). Patients with estrogen receptor–positive (ER+) breast cancer (BC), which account for most cases of BC, have fewer TI…
View article: CNSC-88. DIFFERENCES IN REGIONAL DEVELOPMENTAL ORIGINS OF GLIOBLASTOMAS REVEALED BY INTEGRATED MOLECULAR PROFILING
CNSC-88. DIFFERENCES IN REGIONAL DEVELOPMENTAL ORIGINS OF GLIOBLASTOMAS REVEALED BY INTEGRATED MOLECULAR PROFILING Open
BACKGROUND High-grade IDH-wildtype gliomas are among the most aggressive primary brain tumors, exhibiting extensive molecular heterogeneity. Although previous studies have shown that tumor location can correlate with molecular subtype, it …
View article: Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship
Polygenic scores capture genetic modification of the adiposity-cardiometabolic risk factor relationship Open
Polygenic scores (PGSs) that can predict response to interventions can facilitate precision medicine and are detectable in observational datasets as PGS-by-exposure (PGS×E) interactions. PGSs based on interactions (iPGSs) or variance effec…
View article: Optimizing endocrine adjuvant therapy in HR+/HER2− breast cancer: supplemental strategies and innovations
Optimizing endocrine adjuvant therapy in HR+/HER2− breast cancer: supplemental strategies and innovations Open
Endocrine therapy (ET) is a cornerstone in adjuvant therapy for hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2−) breast cancer. However, recent research challenges the conventional 5-year adjuva…
View article: Comprehensive Assessment of the Genomic Stability of Human Induced Pluripotent Stem Cells for Clinical Applications
Comprehensive Assessment of the Genomic Stability of Human Induced Pluripotent Stem Cells for Clinical Applications Open
Background Human induced pluripotent stem cells (hiPSCs) acquire genomic instability during reprogramming and culture, which poses significant risks for clinical applications. Current detection methods, such as karyotyping analysis, often …
View article: The efficacy of dietary therapies in modulating inflammatory biomarkers, clinical remission and quality of life in patients with inflammatory bowel disease: a network meta-analysis of 15 interventions
The efficacy of dietary therapies in modulating inflammatory biomarkers, clinical remission and quality of life in patients with inflammatory bowel disease: a network meta-analysis of 15 interventions Open
Background Scientific dietary interventions are useful methods for managing inflammatory bowel disease. It is unclear which dietary pattern is most effective in improving IBD symptoms. Therefore, this network meta-analysis compared the imp…
View article: Intrauterine infusion of oil-based medium in women with recurrent implantation failure before frozen embryo transfer: a randomized clinical trial
Intrauterine infusion of oil-based medium in women with recurrent implantation failure before frozen embryo transfer: a randomized clinical trial Open
This study was approved by the Ethics Committee of the First Affiliated Hospital of Guangxi Medical University and registered at the Chinese Clinical Trial Registry Center ( http://www.chictr.org.cn/index.html , no ChiCTR1900024273) on Jul…
View article: Healthy dietary patterns improve sexual function and incontinence symptoms: systematic review and meta-analysis of dietary patterns and dietary interventions
Healthy dietary patterns improve sexual function and incontinence symptoms: systematic review and meta-analysis of dietary patterns and dietary interventions Open
Background Pelvic floor dysfunction (PFD) primarily including urinary incontinence, fecal incontinence, and sexual dysfunction, significantly impairs individuals’ quality of life. While healthy dietary patterns are considered potential mod…
View article: From sleep apnea to arrhythmia: p-wave parameters as non-invasive predictors
From sleep apnea to arrhythmia: p-wave parameters as non-invasive predictors Open
Background Numerous studies have confirmed a significant association between obstructive sleep apnea hypopnea syndrome (OSAHS) and both the increased prevalence and incidence of atrial fibrillation (AF). This study advanced the endpoint ev…
View article: Effects of standardised patients (SP) combined with case-based learning (CBL) in Chinese clinical education: a systematic review and meta-analysis
Effects of standardised patients (SP) combined with case-based learning (CBL) in Chinese clinical education: a systematic review and meta-analysis Open
Objectives Combining standardised patients (SP) with case-based learning (CBL) enriches the learning experience by immersing learners in diverse clinical scenarios. This meta-analysis study aims to assess the intervention effects of this t…
View article: Retrofitting Design of Residential Building Rooftops with Attached Solar Photovoltaic Panels and Thermal Collectors: Weighing Carbon Emissions Against Cost Benefits
Retrofitting Design of Residential Building Rooftops with Attached Solar Photovoltaic Panels and Thermal Collectors: Weighing Carbon Emissions Against Cost Benefits Open
To reduce the carbon emissions of existing residential buildings while pursuing maximum cost benefits, a multi-optimization design method for the existing residential building rooftops, retrofitted by attaching the solar photovoltaic panel…
View article: MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury
MAFF mitigates oxidative stress and pyroptosis in cardiopulmonary bypass-induced myocardium injury Open
Background Cardiopulmonary bypass (CPB) remains an indispensable technique for open-heart surgery; however, it induces systemic inflammation and oxidative stress, leading to myocardial cell damage and compromised prognosis. Optimizing myoc…
View article: Intra-arterial selective hypothermia for acute ischemic stroke neuroprotection: A multicenter pilot trial in China
Intra-arterial selective hypothermia for acute ischemic stroke neuroprotection: A multicenter pilot trial in China Open
Background Acute ischemic stroke (AIS) remains a leading cause of disability and death globally, with limited effective neuroprotective strategies beyond reperfusion therapies. Despite advances in reperfusion treatments, many patients stil…
View article: Severe Anxiety-Induced Respiratory Alkalosis During Repeat Percutaneous Endoscopic Lumbar Discectomy: A Case Report
Severe Anxiety-Induced Respiratory Alkalosis During Repeat Percutaneous Endoscopic Lumbar Discectomy: A Case Report Open
A 44-year-old male with recurrent lumbar disc herniation developed severe anxiety-induced respiratory alkalosis during repeat percutaneous endoscopic lumbar discectomy (PELD) under monitored anesthesia care (MAC). Despite using dexmedetomi…
View article: Whole-tumor histogram analysis of synthetic MRI for discriminating benign from malignant sinonasal tumors: correlations with histopathologic factors
Whole-tumor histogram analysis of synthetic MRI for discriminating benign from malignant sinonasal tumors: correlations with histopathologic factors Open
Whole-tumor histogram quantitative parameters of SyMRI could further improve the diagnostic performance in differentiating benign from malignant sinonasal tumors and may serve as potential biomarkers in assessing the histopathologic featur…
View article: Association between asymmetric dimethylarginine, its change and subclinical carotid atherosclerosis in metabolic dysfunction-associated steatotic liver disease
Association between asymmetric dimethylarginine, its change and subclinical carotid atherosclerosis in metabolic dysfunction-associated steatotic liver disease Open
Background: Asymmetric dimethylarginine (ADMA) is a promising marker for assessing cardiovascular disease risk; however, it is unclear whether ADMA can predict subclinical carotid atherosclerosis (SCA) in individuals with metabolic dysfunc…