Qiang Li
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View article: Helium bubbles retard recrystallization in tungsten by limiting subgrain growth
Helium bubbles retard recrystallization in tungsten by limiting subgrain growth Open
The tungsten plasma facing components (PFCs) in fusion devices must withstand high heat loads. Recrystallization sets in under such conditions and embrittles tungsten, hence motivating its mitigation. He plasma exposure, a natural conseque…
View article: The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy Open
Cellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP). SASP encompasses a wide range of bioactive chemicals, including…
View article: Comparative dosimetric evaluation of single-beam dual-arc <i>versus</i> dual-beam single-arc volumetric modulated arc therapy strategies in lung stereotactic body radiotherapy using Monaco
Comparative dosimetric evaluation of single-beam dual-arc <i>versus</i> dual-beam single-arc volumetric modulated arc therapy strategies in lung stereotactic body radiotherapy using Monaco Open
Background and Objective In stereotactic body radiotherapy (SBRT) for lung cancer, the choice of volumetric modulated arc therapy (VMAT) optimization strategy is critical for achieving optimal target dose coverage while minimizing exposure…
View article: Regulation of a synbiotic herbal-probiotic formula (HBF) on alcohol metabolism in human: A randomized controlled trial
Regulation of a synbiotic herbal-probiotic formula (HBF) on alcohol metabolism in human: A randomized controlled trial Open
Background: Excessive alcohol intake is a global health concern. Short-term alcohol consumption can lead to unpleasant hangover experiences, while long-term excessive intake is associated with liver injury, neurological disorders, cancer, …
View article: Single-cell RNA sequencing across diverse cell types to identify PFOA-induced ovarian cellular senescence
Single-cell RNA sequencing across diverse cell types to identify PFOA-induced ovarian cellular senescence Open
View article: The N-terminal domain of Chlamydia psittaci Pmp19G modulates macrophage autophagy by targeting the NOD1 receptor and the ATG16L1–RAB7 signaling pathway
The N-terminal domain of Chlamydia psittaci Pmp19G modulates macrophage autophagy by targeting the NOD1 receptor and the ATG16L1–RAB7 signaling pathway Open
Introduction Chlamydia psittaci ( C. psittaci ), a zoonotic intracellular Gram-negative bacterium, is responsible for human infections presenting as flu-like fever and community-acquired pneumonia. Previous studies have implicated polymorp…
View article: Application Research of Construction Safety Management in Engineering Risk Assessment
Application Research of Construction Safety Management in Engineering Risk Assessment Open
The collaborative mechanism between construction safety management and engineering risk assessment is the key path to achieving precise control of engineering risks. Research has validated through case analysis that the integrated applicat…
View article: Progress on the Microstructure and Property Regulation of Cu‐15Ni‐8Sn Alloy by Multimode Magnetic Fields and Microalloying
Progress on the Microstructure and Property Regulation of Cu‐15Ni‐8Sn Alloy by Multimode Magnetic Fields and Microalloying Open
The Cu‐15Ni‐8Sn alloy has been widely used in aerospace, marine engineering and electronic components due to its exceptional mechanical properties, corrosion resistance and high‐temperature softening resistance. The inverse segregation and…
View article: Prognostic factors and overall survival for second primary malignancies in myelodysplastic syndromes: a Cox regression coupled with competing risk model based on Surveillance, Epidemiology, and End Results (SEER) database
Prognostic factors and overall survival for second primary malignancies in myelodysplastic syndromes: a Cox regression coupled with competing risk model based on Surveillance, Epidemiology, and End Results (SEER) database Open
A prognostic nomogram was developed and validated to help clinicians assess the prognosis of MSP patients. The establishment of prognostic models can facilitate more comprehensive and precise treatment planning.
View article: Impact of Safety Management Measures on Engineering Risks at Construction Sites
Impact of Safety Management Measures on Engineering Risks at Construction Sites Open
The risk prevention and control in construction projects heavily relies on the systematic optimization of on-site safety management measures. Studies show that technical means such as safety education and training, dynamic monitoring of ha…
View article: Manipulation of the Expression of Tryptophan Decarboxylase Boosts Grain Functional Quality and Stress Resilience Capacity of Wheat
Manipulation of the Expression of Tryptophan Decarboxylase Boosts Grain Functional Quality and Stress Resilience Capacity of Wheat Open
Tryptophan decarboxylase (TDC), the rate‐limiting enzyme of tryptophan metabolism in plants, is essential for the production of a series of bioactive molecules, such as serotonin, melatonin and the plant hormone indole‐3‐acetic acid and th…
View article: Microstructure Evolution, Mechanical Properties, and Corrosion Behavior of Novel Low‐Density Zr–<i>x</i>Al–0.5Si Alloys
Microstructure Evolution, Mechanical Properties, and Corrosion Behavior of Novel Low‐Density Zr–<i>x</i>Al–0.5Si Alloys Open
Herein, pure zirconium (Zr) is alloyed with specified amounts of silicon (Si) and aluminum (Al) in a vacuum arc furnace to create Zr– x Al–0.5Si ( x = 0, 3, 6, 9, 12, 15, 18 at.%) alloys. Thereafter, the phase composition and microstructur…
View article: Demethylase ALKBH5 inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells by decreasing methylation levels and regulating SOCS3/STAT3 signaling
Demethylase ALKBH5 inhibits proliferation and promotes apoptosis of hepatocellular carcinoma cells by decreasing methylation levels and regulating SOCS3/STAT3 signaling Open
In this study, we investigated the role of ALKBH5 in the pathogenesis of hepatocellular carcinoma (HCC), focusing on the underlying molecular mechanisms. Comparative analysis of ALKBH5 expression profiles between hepatocellular carcinoma (…
View article: Immunotherapy with lymphocytes derived from banked tumor tissue in two refractory NSCLC patients with leptomeningeal metastases: a report of two cases
Immunotherapy with lymphocytes derived from banked tumor tissue in two refractory NSCLC patients with leptomeningeal metastases: a report of two cases Open
TILs generated from treatment-responsive lesions and underwent inhibition of EZH2 activity in Tregs have high antitumor efficacy and the banking in advance of treatment-responsive tumor tissue potentially provides a safe and effective adop…
View article: Cloud-Based Big Data Platforms for Real-Time Accounting: A Case Study of E-Commerce Enterprises
Cloud-Based Big Data Platforms for Real-Time Accounting: A Case Study of E-Commerce Enterprises Open
This study examines the transformative impact of cloud-based big data platforms on real-time accounting in e-commerce enterprises. By leveraging scalable and flexible cloud solutions, businesses can enhance operational efficiency, improve …
View article: Robotic Perception with a Large Tactile-Vision-Language Model for Physical Property Inference
Robotic Perception with a Large Tactile-Vision-Language Model for Physical Property Inference Open
Inferring physical properties can significantly enhance robotic manipulation by enabling robots to handle objects safely and efficiently through adaptive grasping strategies. Previous approaches have typically relied on either tactile or v…
View article: Testing quantum entanglement via quantum state tomography with muons
Testing quantum entanglement via quantum state tomography with muons Open
Entanglement is a fundamental pillar of quantum mechanics. Probing quantum entanglement and testing Bell inequality with muons can be a significant leap forward, as the muon is arguably one of the best elementary particles that can be mani…
View article: Modulation of an evolutionarily conserved epigenetic regulon controlling abscisic acid catabolism enhances drought tolerance in wheat
Modulation of an evolutionarily conserved epigenetic regulon controlling abscisic acid catabolism enhances drought tolerance in wheat Open
Summary Drought stress significantly reduces crop yield by triggering abscisic acid (ABA) accumulation in plants. It involves the suppression of CYP707A genes, which encode enzymes that catalyze ABA. However, little is known about epigenet…
View article: Statistical Analysis Plan (SAP): A randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: the CRAFT trial
Statistical Analysis Plan (SAP): A randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: the CRAFT trial Open
The CRAFT trial is designed to evaluate the effects of intensive blood pressure (BP) control in reducing cardiovascular (CV) risks in patients with atrial fibrillation (AF). The trial is a randomized controlled, open-label, parallel-group …
View article: Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma
Autophagy inhibition induced by EM-2 augments apoptosis via ROS-mediated ATM-Chk2-p53-p21 and MAPK pathway in lung and breast carcinoma Open
Lung cancer (LC) and breast cancer (BC) are two common malignant tumors with the highest incidence rate in men and women worldwide, respectively. As the treatment effect of currently available therapies for LC and BC is unsatisfying, searc…
View article: Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein
Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein Open
Vacuolar protein sorting-associated protein 35 (VPS35), a pivotal constituent of the retromer complex, mediates the retrograde trafficking of endosomal cargoes in the cytoplasm. Intriguingly, VPS35 displays a dual localization pattern, res…
View article: A gene expression-based approach for the precision use of hydrocortisone in septic shock patients; a secondary analysis of the ADRENAL trial
A gene expression-based approach for the precision use of hydrocortisone in septic shock patients; a secondary analysis of the ADRENAL trial Open
Gene expression data from patients with septic shock reveal distinct immune endotypes. There was no evidence of a heterogeneity of treatment effect of hydrocortisone on mortality in the 2 endotypes or in the subgroup with severe shock. Pat…
View article: BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma
BAX-mediated ammonia-driven cell death: a novel prognostic and therapeutic target in clear cell renal cell carcinoma Open
View article: Test of LGAD as Potential Next-Generation μSR Spectrometer Detectors
Test of LGAD as Potential Next-Generation μSR Spectrometer Detectors Open
Muon Spin Rotation/Relaxation/Resonance ($μ$SR) is a versatile and powerful non-destructive technology for investigating the magnetic properties of materials at the microscopic level. The $μ$SR technique typically utilizes fully spin polar…
View article: A carbon ion minibeam treatment planning method with scissor beams
A carbon ion minibeam treatment planning method with scissor beams Open
Background Minibeam radiation therapy (MBRT) employs a highly modulated spatial dose distribution characterized by the peak‐to‐valley dose ratio (PVDR). Carbon minibeam radiation therapy (cMBRT) offers higher PVDR and relative biological e…
View article: A Case of a very young female gastric cancer patient undergoing Laparoscopic total gastrectomy with Roux-en-Y anastomosis under a 3D camera.
A Case of a very young female gastric cancer patient undergoing Laparoscopic total gastrectomy with Roux-en-Y anastomosis under a 3D camera. Open
The oncologic outcomes of laparoscopy-assisted gastrectomy for the treatment of gastric cancer have not been evaluated. This study aims to validate the efficacy and safety of laparoscopic gastrectomy for gastric cancer in terms of long-ter…
View article: Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses of ENCHANTED2/MT trial
Interaction of brain imaging features and effects of intensive blood pressure lowering after endovascular treatment for acute ischaemic stroke: the pre-specified secondary analyses of ENCHANTED2/MT trial Open
View article: Anesthetic management of folders with severe kyphosis in ankylosing spondylitis: a single-center retrospective case series study
Anesthetic management of folders with severe kyphosis in ankylosing spondylitis: a single-center retrospective case series study Open
Background Ankylosing spondylitis (AS) is a progressive inflammatory disease causing severe kyphosis, which complicates surgical management and increases complication risks. This study aims to analyze the characteristics of severe kyphosis…
View article: Patient‐specific modeling of radiation‐induced lymphopenia for head and neck cancer
Patient‐specific modeling of radiation‐induced lymphopenia for head and neck cancer Open
Background Radiation‐induced lymphopenia (RIL) is a frequent complication in head and neck cancer (HNC) patients undergoing radiotherapy (RT), and its severity is associated with poorer survival outcomes. Purpose This work aims to develop …
View article: Integrative analysis of ubiquitination-related genes identifies HSPA1A as a critical regulator in colorectal cancer progression
Integrative analysis of ubiquitination-related genes identifies HSPA1A as a critical regulator in colorectal cancer progression Open