Explanipedia

Effect of Ion Release on Color Stability of Zirconia: A Comparative Study Open

Alqarama Mahardhika Thalib, Khanisyah Erza Gumilar, Israyani Israyani, Shang-Ming Wang, Lih Kuo , et al. · 2025

Zirconia ceramics are widely used in dentistry, but maintaining long-term color stability remains challenging. This study investigated the combined effects of specimen thickness, immersion duration, and aging of coloring solutions on the c…

416 Circumcision for Balanitis Xerotica Obliterans: Histopathology Outcomes and Clinical Correlation Open

Lih Kuo, B. Woodward, J Dale, Md. Shahidul Islam, Kailas Bhandarkar · 2025

Aim Circumcision is a common surgical procedure yet remains the topic of ongoing debate. A recent 2021 GIRFT report suggests 4000 unnecessary medical circumcisions are performed in the UK each year resulting in avoidable pain, risk of comp…

Peptide Lv Deficiency Adversely Impacts the Structural and Functional Integrity of the Neural Retina Open

Kofi Owusu-Ansah, Dylan L. Pham, Brower C. Strong, Lora Liberoni, Travis W. Hein , et al. · 2025

Peptide Lv contributes to the maintenance of the structural and functional integrity of adult retinas, and its deficiency accelerates retinal degeneration. These findings highlight a potential neuroprotective role of peptide Lv in the reti…

Activation of Smooth Muscle Kir2.1 Channels and Na+/K+-ATPase Mediates Dilation of Porcine Coronary Arterioles at Physiological Levels of Potassium Open

Travis W. Hein, Habib Moshref Razavi, Xin Xu, Sonal Somvanshi, Mariappan Muthuchamy , et al. · 2025

Metabolic stress on the heart can cause dilation of coronary arterioles for blood flow recruitment. Although potassium ions (K+) released from the myocardium are a major mediator for this response, the underlying signaling pathways for vas…

Activation of Smooth Muscle Kir2.1 Channels and Na+/K+ ATPase Mediates Dilation of Porcine Coronary Arterioles to Potassium Open

Travis W. Hein, Habib Moshref Razavi, Xin Xu, Sonal Somvanshi, Mariappan Muthuchamy , et al. · 2025

Metabolic stress on the heart can cause dilation of coronary arterioles for blood flow recruitment. Although potassium ions (K+) released from the myocardium are a major mediator for this response, the underlying signaling pathways for vas…

H2O2 Mediates VEGF- and Flow-Induced Dilations of Coronary Arterioles in Early Type 1 Diabetes: Role of Vascular Arginase and PI3K-Linked eNOS Uncoupling Open

Naris Thengchaisri, Lih Kuo, Travis W. Hein · 2022

In diabetes, the enzyme arginase is upregulated, which may compete with endothelial nitric oxide (NO) synthase (eNOS) for their common substrate L-arginine and compromise NO-mediated vasodilation. However, this eNOS uncoupling can lead to …

Table of Contents Open

Nimesh R. Patel, Sarah Powers, Richard H. Parrish, Deborah K. VanderVeen, Isdin Oke , et al. · 2022

Intravitreal Administration of Stanniocalcin-1 Rescues Photoreceptor Degeneration with Reduced Oxidative Stress and Inflammation in a Porcine Model of Retinitis Pigmentosa Open

Robert H. Rosa, Wankun Xie, Min Zhao, Shu‐Huai Tsai, Gavin W. Roddy , et al. · 2022

Intravitreal administration of STC-1 enhances cone photoreceptor function, improves EZ integrity, and reduces retinal degeneration through antioxidative and anti-inflammatory effects in a large animal (pig) model of the most common form of…

Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice Open

Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Satoru Yamagami, Akifumi Kushiyama , et al. · 2021

We investigated and compared the susceptibility of retinal blood flow regulation and neural function in mice developing type 2 diabetes. The longitudinal changes in retinal neuronal function and blood flow responses to a 10-min systemic hy…

Activation of Coronary Arteriolar PKCβ2 Impairs Endothelial NO-Mediated Vasodilation: Role of JNK/Rho Kinase Signaling and Xanthine Oxidase Activation Open

Naris Thengchaisri, Travis W. Hein, Yi Ren, Lih Kuo · 2021

Protein kinase C (PKC) activation can evoke vasoconstriction and contribute to coronary disease. However, it is unclear whether PKC activation, without activating the contractile machinery, can lead to coronary arteriolar dysfunction. The …

Contributions of Sodium-Hydrogen Exchanger 1 and Mitogen-Activated Protein Kinases to Enhanced Retinal Venular Constriction to Endothelin-1 in Diabetes Open

Yen‐Lin Chen, Yi Ren, Robert H. Rosa, Lih Kuo, Travis W. Hein · 2021

Diabetes elevates endothelin-1 (ET-1) in the vitreous and enhances constriction of retinal venules to this peptide. However, mechanisms contributing to ET-1–induced constriction of retinal venules are incompletely understood. We examined r…

Longitudinal stability of retinal blood flow regulation in response to flicker stimulation and systemic hyperoxia in mice assessed with laser speckle flowgraphy Open

Junya Hanaguri, Harumasa Yokota, Masahisa Watanabe, Lih Kuo, Satoru Yamagami , et al. · 2020

Hyperglycemia Augments Endothelin-1–Induced Constriction of Human Retinal Venules Open

Yen‐Lin Chen, Robert H. Rosa, Lih Kuo, Travis W. Hein · 2020

Similarities in vasoconstriction to ET-1 between human and porcine retinal venules support the latter as an effective model of the human retinal microcirculation to help identify vascular targets for the treatment of retinal complications …

Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes Open

Travis W. Hein, Tsuneaki Omae, Wenjuan Xu, Akitoshi Yoshida, Lih Kuo · 2020

Arginase, rather than superoxide, impairs endothelium-dependent NOS-mediated dilation of retinal arterioles during diabetes, whereas vasodilation mediated by COX remains intact. Blockade of vascular arginase may improve endothelial functio…

Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis Open

Liheng Shi, Min Zhao, Colette A. Abbey, Shu‐Huai Tsai, Wankun Xie , et al. · 2019

Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling. As vascular endothelial growth factor through vascular endot…

Intravitreal stanniocalcin-2 reduces photoreceptor degeneration and improves oscillatory potentials with elevated ocular blood flow in retinitis pigmentosa Open

Min Zhao, Wankun Xie, Wencong Chen, Travis W. Hein, Lih Kuo , et al. · 2019

Stanniocalcin-1 enhances ellipsoid zone intensity and cone function in the P23H rhodopsin transgenic pig Open

Wankun Xie, Min Zhao, Shu‐Huai Tsai, Maxwell G. Su, Travis W. Hein , et al. · 2019

Hyperglycemia Enhances Constriction of Retinal Venules via Activation of the Reverse-Mode Sodium-Calcium Exchanger Open

Yen‐Lin Chen, Wenjuan Xu, Robert H. Rosa, Lih Kuo, Travis W. Hein · 2019

Diabetes is associated with hyperglycemia and impairment of retinal microvascular function. However, the impact of hyperglycemia on retinal venular constriction remains unknown. We examined retinal venular responsiveness to endogenous vaso…

Requisite roles of LOX-1, JNK, and arginase in diabetes-induced endothelial vasodilator dysfunction of porcine coronary arterioles Open

Travis W. Hein, Xin Xu, Yi Ren, Wenjuan Xu, Shu‐Huai Tsai , et al. · 2019

Data on SD-OCT image acquisition, ultrastructural features, and horizontal tissue shrinkage in the porcine retina Open

Wankun Xie, Min Zhao, Shu‐Huai Tsai, William L. Burkes, Luke B. Potts , et al. · 2018

Constriction of Retinal Venules to Endothelin-1: Obligatory Roles of ET<sub>A</sub> Receptors, Extracellular Calcium Entry, and Rho Kinase Open

Yen‐Lin Chen, Yi Ren, Wenjuan Xu, Robert H. Rosa, Lih Kuo , et al. · 2018

Extracellular Ca2+ entry via L-VOCCs is essential for developing and maintaining basal tone of porcine retinal venules. ET-1 causes significant constriction of retinal venules by activating ETARs and extracellular Ca2+ entry independent of…

Correlation of spectral domain optical coherence tomography with histology and electron microscopy in the porcine retina Open

Wankun Xie, Min Zhao, Shu‐Huai Tsai, William L. Burkes, Luke B. Potts , et al. · 2018

Spectral domain optical coherence tomography (SD-OCT) is used as a non-invasive tool for retinal morphological assessment in vivo. Information on the correlation of SD-OCT with retinal histology in the porcine retina, a model resembling th…

Intravitreal Stanniocalcin-1 Enhances New Blood Vessel Growth in a Rat Model of Laser-Induced Choroidal Neovascularization Open

Min Zhao, Wankun Xie, Shu‐Huai Tsai, Travis W. Hein, Brent A. Rocke , et al. · 2018

Chorodial tissue expresses STC-1, which seemingly acts as a stress response protein by enhancing pathological new blood vessel growth in laser-induced CNV. It is likely that STC-1 promotes CNV development via VEGF signaling.

Alterations of Ocular Hemodynamics Impair Ophthalmic Vascular and Neuroretinal Function Open

Shu‐Huai Tsai, Wankun Xie, Min Zhao, Robert H. Rosa, Travis W. Hein , et al. · 2018

Correlation of Fundus Autofluorescence and Histology of Laser-induced Choroidal Neovascularization in the Rat Open

Min Zhao, Wankun Xie, Shu‐Huai Tsai, Brent A. Rocke, Travis W. Hein , et al. · 2017

Alteration of ocular blood pressure and flow leads to ophthalmic vascular and neuroretinal dysfunction Open

Shu‐Huai Tsai, Wankun Xie, Min Zhao, Robert H. Rosa, Travis W. Hein , et al. · 2017

Enhanced endothelin-1/Rho-kinase signalling and coronary microvascular dysfunction in hypertensive myocardial hypertrophy Open

Shu‐Huai Tsai, Guangrong Lu, Xin Xu, Yi Ren, Travis W. Hein , et al. · 2017

Myocardial hypertrophy induced by pressure overload leads to cardiac and coronary microvascular dysfunction and ischaemia possibly due to oxidative stress, enhanced vasoconstriction to ET-1 and compromised endothelial NO function via eleva…

Correlation of spectral domain optical coherence tomography and histology in the porcine retina Open

Wankun Xie, Min Zhao, Shu‐Huai Tsai, William L. Burkes, Yi Ren , et al. · 2016

Arterial hypertension induces ocular vascular dysfunction in mice with pressure-overload cardiac hypertrophy Open

Shu‐Huai Tsai, Wankun Xie, Min Zhao, Robert H. Rosa, Travis W. Hein , et al. · 2016

Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor Open

Shinichi Otani, Taiji Nagaoka, Tsuneaki Omae, Ichiro Tanano, Takayuki Kamiya , et al. · 2016

The endothelium plays an essential role in the dilation of porcine retinal arterioles to histamine via H1- and H2-receptor activation. The EDHF derived from cytochrome P450 contributed in part to this vasodilation via KCa channel activatio…

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