Li‐Na Wei
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View article: Targeting CRABP1 Signalosomes in Managing Neurodegeneration
Targeting CRABP1 Signalosomes in Managing Neurodegeneration Open
Retinoic acid (RA) binds RA (RAR) and Retinoid X (RXR) receptors to elicit biological effects by regulating transcription. RA is also known to have non-canonical activities mediated, primarily, by cellular retinoic acid-binding protein 1 (…
View article: Efficacy and safety of Sublingual immunotherapy for allergic rhinitis: an overview of systematic reviews and meta analyses
Efficacy and safety of Sublingual immunotherapy for allergic rhinitis: an overview of systematic reviews and meta analyses Open
Current evidence demonstrates that Sublingual Immunotherapy exhibits favorable efficacy in improving symptom scores and medication use for allergic rhinitis, with generally acceptable safety profiles despite mild adverse reactions in some …
View article: Single-incision robotic nipple-sparing mastectomy with immediate breast reconstruction: a comprehensive surgical technique and strategy
Single-incision robotic nipple-sparing mastectomy with immediate breast reconstruction: a comprehensive surgical technique and strategy Open
With the increasing application of robotic surgical systems in various surgical fields and the progressive refinement of endoscopic breast surgery, robotic breast surgery has been actively explored and implemented. Robotic surgical platfor…
View article: Cognition of decision behavior based on belief state: a case study of implementation in CGF simulation system
Cognition of decision behavior based on belief state: a case study of implementation in CGF simulation system Open
In the field of modern military warfare, decision behavior modeling of Agents is a critical approach for simulating the decision-making process of various military entities in battlefield environments. However, existing models suffer from …
View article: CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid—Maintaining Health and Preventing Thyroid Dysfunction in Aging
CRABP1 Signalosomes in Non-Canonical Actions of Retinoic Acid—Maintaining Health and Preventing Thyroid Dysfunction in Aging Open
Retinoic acid (RA) exerts biological effects through RA receptors (RARs) to regulate transcription. RA also elicits rapid, RAR-independent (noncanonical) activities mediated by Cellular RA Binding Protein 1 (CRABP1) to modulate cytosolic s…
View article: Research on Education Guarantee of Rural Left-Behind Children under the Background of Rural Revitalization
Research on Education Guarantee of Rural Left-Behind Children under the Background of Rural Revitalization Open
This study analyzes the opportunities and challenges of ensuring education for rural left-behind children in China within the context of rural revitalization. By reflecting on the difficulties in providing educational support, it seeks to …
View article: Traditional Chinese medicine strategies to optimize antibiotic use and reduce the burden of antibiotic resistance in Chinese children
Traditional Chinese medicine strategies to optimize antibiotic use and reduce the burden of antibiotic resistance in Chinese children Open
Antibiotic resistance is one of the greatest threats to human health, especially children's health. Traditional Chinese medicine encompasses several documented treatments for pediatric infectious diseases. The antibacterial efficacy and po…
View article: Modelling Functional Thyroid Follicular Structures Using P19 Embryonal Carcinoma Cells
Modelling Functional Thyroid Follicular Structures Using P19 Embryonal Carcinoma Cells Open
Thyroid gland diseases remain clinical challenges due to the lack of reliable in vitro models to examine molecular pathways of thyrocytes development, maturation, and functional maintenance. This study aimed to develop in vitro thyrocytes …
View article: RESEARCH ON THE MECHANISM OF WORK STRESS IMPACT ON THE CONSTRUCTION WORKERS UNSAFE BEHAVIOR
RESEARCH ON THE MECHANISM OF WORK STRESS IMPACT ON THE CONSTRUCTION WORKERS UNSAFE BEHAVIOR Open
In order to deeply explore the relationship between work stress and the unsafe behavior of construction workers, a questionnaire survey was used. First, select individual job burnout as an intermediary variable based on their work characte…
View article: Described Spatial-Temporal Video Detection
Described Spatial-Temporal Video Detection Open
Detecting visual content on language expression has become an emerging topic in the community. However, in the video domain, the existing setting, i.e., spatial-temporal video grounding (STVG), is formulated to only detect one pre-existing…
View article: Depleting Cellular Retinoic Acid Binding Protein 1 Impairs UPRmt
Depleting Cellular Retinoic Acid Binding Protein 1 Impairs UPRmt Open
Mitochondrial dysfunction underlines neurodegenerative diseases which are mostly characterized by progressive degeneration of neurons. We previously reported that Cellular retinoic acid Binding protein 1 (Crabp1) knockout (CKO) mice sponta…
View article: Molecular basis for cellular retinoic acid-binding protein 1 in modulating CaMKII activation
Molecular basis for cellular retinoic acid-binding protein 1 in modulating CaMKII activation Open
Introduction: Cellular retinoic acid (RA)-binding protein 1 (CRABP1) is a highly conserved protein comprised of an anti-parallel, beta-barrel, and a helix-turn-helix segment outside this barrel. Functionally, CRABP1 is thought to bind and …
View article: CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells
CRABP1-mediated non-canonical retinoic acid signaling in motor neurons and neural stem cells Open
Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA *Correspondence to: Li-Na Wei, PhD, [email protected]. This is an open-access article distributed under the terms of the Creative Commons Attribution-…
View article: A novel 3D bilayer hydrogel tri-culture system for studying functional motor units
A novel 3D bilayer hydrogel tri-culture system for studying functional motor units Open
Background A motor unit (MU) is formed by a single alpha motor neuron (MN) and the muscle fibers it innervates. The MU is essential for all voluntary movements. Functional deficits in the MU result in neuromuscular disorders (NMDs). The pa…
View article: Giant breast phyllodes tumor with silent thromboembolism: A case report
Giant breast phyllodes tumor with silent thromboembolism: A case report Open
Background Phyllodes tumor (PT) is a solid fibroepithelial breast lesion with proliferation of stromal and epithelial elements, usually presents with a rapidly expanding feature. Venous thromboembolism (VTE) have been reported to increase …
View article: The study of the effectiveness of design-based engineering learning: the mediating role of cognitive engagement and the moderating role of modes of engagement
The study of the effectiveness of design-based engineering learning: the mediating role of cognitive engagement and the moderating role of modes of engagement Open
Aim Design-based engineering learning (DBEL) offers a potentially valuable approach to engineering education, but its mechanism of action has yet to be verified by empirical studies. Accordingly, the present study aimed to establish whethe…
View article: Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration
Targeting Cellular Retinoic Acid Binding Protein 1 with Retinoic Acid-like Compounds to Mitigate Motor Neuron Degeneration Open
All-trans-retinoic Acid (atRA) is the principal active metabolite of Vitamin A, essential for various biological processes. The activities of atRA are mediated by nuclear RA receptors (RARs) to alter gene expression (canonical activities) …
View article: Deleting Cellular Retinoic-Acid-Binding Protein-1 (Crabp1) Gene Causes Adult-Onset Primary Hypothyroidism in Mice
Deleting Cellular Retinoic-Acid-Binding Protein-1 (Crabp1) Gene Causes Adult-Onset Primary Hypothyroidism in Mice Open
Adult-onset primary hypothyroidism is commonly caused by iatrogenic or autoimmune mechanisms; whether other factors might also contribute to adult hypothyroidism is unclear. Cellular Retinoic-Acid-Binding Protein 1 (CRABP1) is a mediator f…
View article: Multidimensional Characteristics of Design-Based Engineering Learning: A Grounded Theory Study
Multidimensional Characteristics of Design-Based Engineering Learning: A Grounded Theory Study Open
Design-based engineering learning is an important learning model in the field of engineering education research, and also an important embodiment of sustainable development engineering education. At present, the research is still in the st…
View article: Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis
Mahuang Decoction Attenuates Airway Inflammation and Remodeling in Asthma via Suppression of the SP1/FGFR3/PI3K/AKT Axis Open
Taken together, MHD may retard airway inflammation and remodeling by suppressing the SP1/FGFR3/PI3K/AKT axis, which contributes to an extensive understanding of asthma and may provide novel therapeutic options for this disease.
View article: CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases
CRABP1 in Non-Canonical Activities of Retinoic Acid in Health and Diseases Open
In this review, we discuss the emerging role of Cellular Retinoic Acid Binding Protein 1 (CRABP1) as a mediator of non-canonical activities of retinoic acid (RA) and relevance to human diseases. We first discuss the role of CRABP1 in regul…
View article: Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression
Crabp1 Modulates HPA Axis Homeostasis and Anxiety-like Behaviors by Altering FKBP5 Expression Open
Retinoic acid (RA), the principal active metabolite of vitamin A, is known to be involved in stress-related disorders. However, its mechanism of action in this regard remains unclear. This study reports that, in mice, endogenous cellular R…