Wen‐Wu Li
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View article: Tanshinone IIA and hydroxy safflower yellow A reduce cerebral injury via TLR4/NF-κB pathway in rats
Tanshinone IIA and hydroxy safflower yellow A reduce cerebral injury via TLR4/NF-κB pathway in rats Open
Cerebral ischemia-reperfusion injury (CIRI) is a cerebrovascular disorder with high rates of incidence, disability, and death. It has been identified that Salvia miltiorrhiza and safflower have a protective effect in CIRI. However, the mec…
View article: Yuyang Decoction Regulates Macrophage Polarization and Repairs the Intestinal Mucosal Barrier via the TLRs/Tollip Signaling Pathway
Yuyang Decoction Regulates Macrophage Polarization and Repairs the Intestinal Mucosal Barrier via the TLRs/Tollip Signaling Pathway Open
YYD alleviates DSS-induced colitis by enhancing intestinal barrier repair and modulating immune responses. Its therapeutic effect may involve activation of the Tollip signaling pathway, which inhibits pro-inflammatory M1-like macrophage di…
View article: Exercise plasma improves traumatic brain injury outcomes in mice
Exercise plasma improves traumatic brain injury outcomes in mice Open
Traumatic brain injury (TBI) is associated with pain and cognitive impairment although exercise may improve some adverse outcomes. We hypothesized that transfer of plasma derived from exercised mice would improve outcomes related to pain a…
View article: A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices
A bacteriocin-based coating strategy to prevent vancomycin-resistant Enterococcus faecium biofilm formation on materials of interest for indwelling medical devices Open
The ever-increasing use of exogenous materials as indwelling medical devices in modern medicine offers to pathogens new ways to gain access to human body and begin, in some cases, life threatening infections. Biofouling of such materials w…
View article: The Influence of Emerging Sports on The Wellness Dimensions of The Public Middle School Students in China
The Influence of Emerging Sports on The Wellness Dimensions of The Public Middle School Students in China Open
The physical quality of our citizens is declining, especially among primary and secondary school students. The decline is particularly serious. This study aims to explore the level of influence of emerging sports on the Wellness dimensions…
View article: Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis
Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis Open
Background Atherosclerosis is a lipid-driven inflammatory disease characterized by plaque formation in major arteries. These plaques contain lipid-rich macrophages that accumulate through monocyte recruitment, local macrophage differentiat…
View article: Case Report: Multiple gastrointestinal stromal tumors along with numerous cutaneous neurofibromas: a case description and literature analysis
Case Report: Multiple gastrointestinal stromal tumors along with numerous cutaneous neurofibromas: a case description and literature analysis Open
Multiple gastrointestinal stromal tumors (GISTs) combined with cutaneous multiple neurofibromas are clinically rare. This paper presents a case of multiple gastrointestinal stromal tumors in the jejunum of a 68-year-old mother, along with …
View article: Dietary phytochemicals against COVID‐19: A focus on thymoquinone
Dietary phytochemicals against COVID‐19: A focus on thymoquinone Open
It has been three years since the outbreak of the Coronavirus disease 2019 (COVID-19) at the end of 2019 in Wuhan, China, which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). So far, over six million people …
View article: Traditional processing techniques impacted the bioactivities of selected local consumed foods
Traditional processing techniques impacted the bioactivities of selected local consumed foods Open
Epidemiological and clinical studies have evidenced the crucial role of vegetables and mushrooms for our health. Vegetables and mushrooms are usually cooked before consumption which induces many physicochemical changes in foods. A change i…
View article: Pronociceptive autoantibodies in the spinal cord mediate nociceptive sensitization, loss of function, and spontaneous pain in the lumbar disk puncture model of chronic back pain
Pronociceptive autoantibodies in the spinal cord mediate nociceptive sensitization, loss of function, and spontaneous pain in the lumbar disk puncture model of chronic back pain Open
Previously, we observed that B cells and autoantibodies mediated chronic nociceptive sensitization in the mouse tibia fracture model of complex regional pain syndrome and that complex regional pain syndrome patient antibodies were pronocic…
View article: In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum
In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum Open
Solanum anomalum is a plant used ethnomedically for the treatment of diabetes. The study was aimed to validate ethnomedical claims in rat model and identify the likely antidiabetic compounds. Leaf extract (70-210 mg/kg/day) and fractions (…
View article: In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis
In Vivo Antibacterial Efficacy of Antimicrobial Peptides Modified Metallic Implants─Systematic Review and Meta-Analysis Open
Biomaterial-associated infection is difficult to detect and brings consequences that can lead to morbidity and mortality. Bacteria can adhere to the implant surface, grow, and form biofilms. Antimicrobial peptides (AMPs) can target and kil…
View article: Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger
Biotransformation of artemisinin to a novel derivative via ring rearrangement by Aspergillus niger Open
Artemisinin is a component part of current frontline medicines for the treatment of malaria. The aim of this study is to make analogues of artemisinin using microbial transformation and evaluate their in vitro antimalarial activity. A pane…
View article: Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells
Sesquiterpene Lactones Modulated DNA Methylation through Inhibition of DNMTs in Ovarian Cancer Cells Open
Inappropriate DNA methylation of tumour suppressor genes can affect their expression and function, and as such, DNA methylation has been a promising target for anti-cancer therapy. In gynaecological malignancy, ovarian cancer has the highe…
View article: Identification of foods that affect the anti‑cancer activity of pitavastatin in cells
Identification of foods that affect the anti‑cancer activity of pitavastatin in cells Open
Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to geranylgeraniol that is necessary for the post-translational modification of several small GTPase oncogenes. Despite numerous preclinical studies suggesting th…
View article: Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats
Phytochemical characterization, antihyperglycaemic and antihyperlipidemic activities of Setaria megaphylla in alloxan-induced diabetic rats Open
Background: Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a grass used ethnomedically by herbalists in Nigeria for the treatment of diabetes was evaluated for antidiabetic, hypolipidemic and pancreas protective potentials in rats. Met…
View article: Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells
Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells Open
Objectives: The toxicity of chemotherapeutic anticancer drugs is a serious issue in clinics. Drug discovery from edible and medicinal plants represents a promising approach towards finding safer anticancer therapeutics. Justicia insularis …
View article: Circulating microRNAs from the mouse tibia fracture model reflect the signature from patients with complex regional pain syndrome
Circulating microRNAs from the mouse tibia fracture model reflect the signature from patients with complex regional pain syndrome Open
Introduction: Complex regional pain syndrome (CRPS) often results from an initial trauma that later produces a disproportionate amount of pain. The mechanisms underlying CRPS have been studied using a tibia fracture model (TFM) in rodents …
View article: Dimethyl Fumarate Reduces Oxidative Stress and Pronociceptive Immune Responses in a Murine Model of Complex Regional Pain Syndrome
Dimethyl Fumarate Reduces Oxidative Stress and Pronociceptive Immune Responses in a Murine Model of Complex Regional Pain Syndrome Open
BACKGROUND: Complex regional pain syndrome (CRPS) is a highly disabling cause of pain often precipitated by surgery or trauma to a limb. Both innate and adaptive immunological changes contribute to this syndrome. Dimethyl fumarate (DMF) wo…
View article: <i>In Vivo</i> Efficacy and Metabolism of the Antimalarial Cycleanine and Improved <i>In Vitro</i> Antiplasmodial Activity of Semisynthetic Analogues
<i>In Vivo</i> Efficacy and Metabolism of the Antimalarial Cycleanine and Improved <i>In Vitro</i> Antiplasmodial Activity of Semisynthetic Analogues Open
Bisbenzylisoquinoline (BBIQ) alkaloids are a diverse group of natural products that demonstrate a range of biological activities. In this study, the in vitro antiplasmodial activity of three BBIQ alkaloids (cycleanine [compound 1], isochon…
View article: C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice Open
It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration…
View article: Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress
Methyl gallate – Rich fraction of Syzygium coriaceum leaf extract induced cancer cell cytotoxicity via oxidative stress Open
Whilst the pharmacological potential of Syzygium species is well reported in the literature, data on the Mauritian endemic Syzygium species is limited. Thus, the in vitro antioxidant and anti-proliferative properties of three endangered Sy…
View article: Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest
Terminalia bentzoë, a Mascarene Endemic Plant, Inhibits Human Hepatocellular Carcinoma Cells Growth In Vitro via G0/G1 Phase Cell Cycle Arrest Open
Tropical forests constitute a prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remain unexplored. The scarcity of rigorous scientific data on the surviving Mascarene endemic taxa renders …
View article: <strong>Focus on Mascarenes Endemic Plants with Specific Phytochemical Composition, Potent Antioxidant and Antiproliferative Properties</strong>
<strong>Focus on Mascarenes Endemic Plants with Specific Phytochemical Composition, Potent Antioxidant and Antiproliferative Properties</strong> Open
Tropical forests constitute prolific sanctuary of unique floral diversity and potential medicinal sources, however, many of them remains unexplored. Herein, seven Mascarene endemic plants leaves were extracted and evaluated for their in vi…
View article: Occurrence of Stem Blight and Fruit Rot Caused by <i>Phytophthora capsici</i> on Chinese Cucumber (<i>Trichosanthes kirilowii</i>) in China
Occurrence of Stem Blight and Fruit Rot Caused by <i>Phytophthora capsici</i> on Chinese Cucumber (<i>Trichosanthes kirilowii</i>) in China Open
Chinese cucumber, Trichosanthes kirilowii Maxim, is a perennial liana plant belonging to the Cucurbitaceae family and is an important traditional medicine in Chinese herbalism. The root, fruit and seed possess the medicinal value, and also…