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View article: Supplement 5 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Supplement 5 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
Representativeness of Study Participants
View article: Supplement 1 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Supplement 1 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
Study protocol
View article: Supplement 3 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Supplement 3 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
Figure S1-S5
View article: Supplement 4 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Supplement 4 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
Table S1-S3
View article: Data from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Data from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
Purpose:Preclinical and clinical findings suggest that PD-1/cytotoxic T lymphocyte–associated protein 4 bispecific antibodies may offer synergistic antitumor activity. This study aimed to explore the efficacy and safety of cadonilimab comb…
View article: Supplement 2 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial
Supplement 2 from Cadonilimab (a PD-1/CTLA-4 Bispecific Antibody) plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase II Clinical Trial Open
TREND Statement Checklist
View article: Does Pulsed Low-Dose Rate Radiotherapy Reduce the Dose to Circulating Lymphocytes in Glioblastoma?
Does Pulsed Low-Dose Rate Radiotherapy Reduce the Dose to Circulating Lymphocytes in Glioblastoma? Open
View article: Analysis of red blood cell lifespan and associated influencing factors in anemic dialysis patients
Analysis of red blood cell lifespan and associated influencing factors in anemic dialysis patients Open
This study demonstrated that independent risk factors contributing to this reduction in RBC lifespan include male, elevated BMI, increased TIBC, and decreased adjusted calcium levels. Additionally, the type of anti-anemia therapy administe…
View article: Diagnostic value of ultrasound radiomic features in differentiating benign and malignant breast lesions
Diagnostic value of ultrasound radiomic features in differentiating benign and malignant breast lesions Open
View article: OP0306 ANAEROBICIDAL ANTIBIOTIC USE AND RISK OF GOUT FLARES: TARGET TRIAL EMULATION FOR POTENTIAL ROLE OF THE MICROBIOME IN GOUT WITH CHRONIC KIDNEY DISEASE (CKD)
OP0306 ANAEROBICIDAL ANTIBIOTIC USE AND RISK OF GOUT FLARES: TARGET TRIAL EMULATION FOR POTENTIAL ROLE OF THE MICROBIOME IN GOUT WITH CHRONIC KIDNEY DISEASE (CKD) Open
View article: <scp>CgABR1</scp>‐<scp><i>CgFAD</i></scp> negatively regulates the fruit neck length in citrus
<span>CgABR1</span>‐<span><i>CgFAD</i></span> negatively regulates the fruit neck length in citrus Open
Summary Pummelo ( Citrus maxima ) is a fundamental species of Citrus which contributes to most of the cultivated citrus, including sweet orange, lemon and etc. The fruit neck is a structural feature of pummelo, and a long fruit neck reduce…
View article: Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial
Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial Open
View article: Four cycles of docetaxel plus cisplatin as neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in stage N2-3 nasopharyngeal carcinoma: phase 3 multicentre randomised controlled trial
Four cycles of docetaxel plus cisplatin as neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in stage N2-3 nasopharyngeal carcinoma: phase 3 multicentre randomised controlled trial Open
Objective To compare the effects of four cycles of docetaxel with cisplatin as a neoadjuvant chemotherapy followed by concurrent chemoradiotherapy with concurrent chemoradiotherapy alone by assessing reductions in distant metastasis and im…
View article: Longitudinal profiles of oral microbiome in patients with nasopharyngeal carcinoma and their prognostic implications
Longitudinal profiles of oral microbiome in patients with nasopharyngeal carcinoma and their prognostic implications Open
NPC treatment can cause persistent decline in microbial diversity of salivary microbiome and abundances of NPC-associated bacteria, and candidate bacteria could be an explanatory factor for NPC prognosis and deserve intensive research.
View article: Influence of Inflammation on Red Blood Cell Lifespan in Peritoneal Dialysis Patients
Influence of Inflammation on Red Blood Cell Lifespan in Peritoneal Dialysis Patients Open
Background and hypothesis: Renal anemia is linked to a decreased lifespan of red blood cells. The factors influencing red blood cell lifespan (RBCLS) in peritoneal dialysis patients, particularly the connection between inflammation and RBC…
View article: A 53‐year‐old woman with a 16‐year history of epilepsy
A 53‐year‐old woman with a 16‐year history of epilepsy Open
View article: Short-term peritoneal rest reduces peritoneal solute transport rate and increases ultrafiltration in high/high average transport peritoneal dialysis patients: a crossover randomized controlled trial
Short-term peritoneal rest reduces peritoneal solute transport rate and increases ultrafiltration in high/high average transport peritoneal dialysis patients: a crossover randomized controlled trial Open
Background The peritoneal solute transport rate (PSTR) tends to increase over time in some patients undergoing peritoneal dialysis (PD), potentially leading to ultrafiltration (UF) failure. Previous case reports have shown a significant de…
View article: #766 A prognostic model (BLEND35) with internal validation for treatment failure in patients with peritoneal dialysis-associated peritonitis
#766 A prognostic model (BLEND35) with internal validation for treatment failure in patients with peritoneal dialysis-associated peritonitis Open
Background and Aims Globally, peritoneal dialysis (PD)-associated peritonitis (PDAP) is a common and severe complication in PD. Early identification of high risk PDAP helps to prevent adverse outcomes. Currently, there is no recognized pre…
View article: #1262 Risk factors of peritoneal dialysis associated peritonitis caused by gram-negative bacteria: a single-center retrospective study over 16 years
#1262 Risk factors of peritoneal dialysis associated peritonitis caused by gram-negative bacteria: a single-center retrospective study over 16 years Open
Background and Aims To analyse the clinical characteristics, pathogen distribution, and treatment outcomes of peritoneal dialysis associated peritonitis (PDAP) caused by gram-negative bacteria, and explore the risk factors for the occurren…
View article: Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas
Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas Open
Histone methyltransferase EZH2, primarily localized in the nucleus, mediates constitutive Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), leading to gene silencing through canonical and noncanonic…
View article: miR-153 promotes neural differentiation by activating the cell adhesion/Ca2+ signaling pathway and targeting ion channel activity in HT-22 cells by bioinformatic analysis
miR-153 promotes neural differentiation by activating the cell adhesion/Ca2+ signaling pathway and targeting ion channel activity in HT-22 cells by bioinformatic analysis Open
MicroRNAs have been studied extensively in neurodegenerative diseases. In a previous study, miR-153 promoted neural differentiation and projection formation in mouse hippocampal HT-22 cells. However, the pathways and molecular mechanism un…
View article: Risk Factors of the Occurrence and Treatment Failure of Refractory Peritoneal Dialysis‐Associated Peritonitis: A Single‐Center Retrospective Study From China
Risk Factors of the Occurrence and Treatment Failure of Refractory Peritoneal Dialysis‐Associated Peritonitis: A Single‐Center Retrospective Study From China Open
Background This study aimed to investigate the clinical characteristics and prognosis of refractory peritoneal dialysis (PD)‐associated peritonitis as well as the risk factors of its occurrence and treatment failure. Methods A single‐cente…
View article: A real-time augmented reality system integrated with artificial intelligence for skin tumor surgery: experimental study and case series
A real-time augmented reality system integrated with artificial intelligence for skin tumor surgery: experimental study and case series Open
Background: Skin tumors affect many people worldwide, and surgery is the first treatment choice. Achieving precise preoperative planning and navigation of intraoperative sampling remains a problem and is excessively reliant on the experien…
View article: Neoadjuvant chemo-immunotherapy with camrelizumab plus nab-paclitaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck: a pilot phase II trial
Neoadjuvant chemo-immunotherapy with camrelizumab plus nab-paclitaxel and cisplatin in resectable locally advanced squamous cell carcinoma of the head and neck: a pilot phase II trial Open
View article: RADT-02. WHOLE-BRAIN RADIATION THERAPY WITH SIMULTANEOUS INTEGRATED BOOST VERSUS STEREOTACTIC RADIOTHERAPY FOR THE TREATMENT OF BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER
RADT-02. WHOLE-BRAIN RADIATION THERAPY WITH SIMULTANEOUS INTEGRATED BOOST VERSUS STEREOTACTIC RADIOTHERAPY FOR THE TREATMENT OF BRAIN METASTASIS FROM NON-SMALL CELL LUNG CANCER Open
OBJECTIVE To compare whole-brain radiotherapy with a simultaneous integrated boost (WBRT-SIB) to stereotactic radiotherapy (SRT) in treating non-small cell lung cancer (NSCLC) patients with brain metastases (BMs). METHODS Between April 201…
View article: The impact of radiosensitivity on clinical outcomes of spinal metastases treated with stereotactic body radiotherapy
The impact of radiosensitivity on clinical outcomes of spinal metastases treated with stereotactic body radiotherapy Open
Background To evaluate the impact of radiosensitivity on outcomes of spinal metastases treated with stereotactic body radiotherapy (SBRT) and identify the correlated prognostic factors. Methods The authors retrospectively reviewed the reco…
View article: Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study
Photodynamic therapy combined with surgery versus Mohs micrographic surgery for the treatment of difficult-to-treat basal cell carcinoma: a retrospective clinical study Open
Mohs micrographic surgery (MMS) is the preferable surgery for difficult -to-treat basal cell carcinoma (BCC) but is an expensive, labor-intensive, and time-consuming technique. The aim of this study is to compare the efficacy and safety of…
View article: Prognostic value of the immunohistochemical score based on four markers in head and neck squamous cell carcinoma
Prognostic value of the immunohistochemical score based on four markers in head and neck squamous cell carcinoma Open
Purpose Head and neck squamous cell carcinoma (HNSCC) ranks sixth among all cancers globally regarding morbidity, and it has a poor prognosis, high mortality, and highly aggressive properties. In this study, we established a model for pred…
View article: Effect of different dialysis duration on the prognosis of peritoneal dialysis-associated peritonitis: a single-center, retrospective study
Effect of different dialysis duration on the prognosis of peritoneal dialysis-associated peritonitis: a single-center, retrospective study Open
Peritoneal dialysis (PD)-associated peritonitis is a serious complication observed in peritoneal dialysis patients. Herein, we investigated the clinical characteristics and treatment outcomes of PD peritonitis in patients with different PD…
View article: Quality of life and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study
Quality of life and Its Association With Radiation-Induced Oral Mucositis in Patients With Nasopharyngeal Carcinoma During Radiotherapy: A Prospective Study Open
We aimed to investigate the quality of life of nasopharyngeal carcinoma (NPC) patients during treatment and association with radiation-induced oral mucositis (ROM). A prospective study of 173 patients with nasopharyngeal carcinoma was init…