Xiangdong Li
YOU?
Author Swipe
View article: Mass Spectrometry-Based Proteomic Analysis of Porcine Reproductive and Respiratory Syndrome Virus NSP9 Protein with Host Proteins
Mass Spectrometry-Based Proteomic Analysis of Porcine Reproductive and Respiratory Syndrome Virus NSP9 Protein with Host Proteins Open
Porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein 9 (NSP9), the viral RNA-dependent RNA polymerase (RdRp), is essential for viral replication but its comprehensive host interactome remains uncharacterized. T…
View article: TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation
TRIM29 inhibits PRRSV replication by targeting nsp11 for degradation Open
Ubiquitination plays critical roles in viral infections. This study demonstrates that porcine reproductive and respiratory syndrome virus (PRRSV) endoribonuclease nsp11 undergoes K48-linked polyubiquitination specifically at the conserved …
View article: Indirect ELISA Using Multi-Antigenic Dominants of 3AB and 3C Recombinant Protein to Detect Antibodies Against Senecavirus A in Pigs
Indirect ELISA Using Multi-Antigenic Dominants of 3AB and 3C Recombinant Protein to Detect Antibodies Against Senecavirus A in Pigs Open
Senecavirus A (SVA) causes a vesicular disease in pigs with clinical signs indistinguishable from those of other swine vesicular diseases. To enable serological differentiation infected from vaccinated animals (DIVA), we developed indirect…
View article: The role of neutrophils, red blood cells, and platelets in the pathology of Alzheimer’s disease
The role of neutrophils, red blood cells, and platelets in the pathology of Alzheimer’s disease Open
This review synthesizes recent advances in understanding the contributions of neutrophils, RBCs and platelets to AD pathology, which is promising to provide a transformative perspective and evidence for the in-depth understanding of the pa…
View article: Molecular Characterization of a Recombinant NADC30-like PRRSV Strain with a Novel Gene Deletion Pattern in Nsp2 Gene
Molecular Characterization of a Recombinant NADC30-like PRRSV Strain with a Novel Gene Deletion Pattern in Nsp2 Gene Open
PRRSV poses a persistent global challenge to the swine industry due to its rapid evolution. This study aimed to characterize a novel PRRSV2 strain, HeB2023092, isolated from a suspected outbreak in China in September 2023. We performed vir…
View article: N-terminal truncation of the foot-and-mouth disease virus VP0 protein promotes soluble co-expression and particle assembly stability of viral capsid proteins in Escherichia coli
N-terminal truncation of the foot-and-mouth disease virus VP0 protein promotes soluble co-expression and particle assembly stability of viral capsid proteins in Escherichia coli Open
Collectively, our findings establish a robust platform for the efficient production of structurally stable FMDV VLPs in E. coli, providing a valuable framework for developing soluble expression systems for other FMDV serotypes.
View article: Multiplex nucleic acid polymerase assay for eight severe hemorrhagic fever viruses based on dual-probe hybridization and melting curve analysis
Multiplex nucleic acid polymerase assay for eight severe hemorrhagic fever viruses based on dual-probe hybridization and melting curve analysis Open
The MPA-eight-virus assay is high throughput, time-saving, accurate, and cost-effective, making it potentially useful for prevention and control of severe viral hemorrhagic fever.
View article: Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus
Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus Open
African Swine Fever Virus (ASFV) is a highly contagious pathogen responsible for substantial economic losses in swine populations worldwide. Despite extensive research, the mechanisms underlying the genomic evolution of ASFV remain poorly …
View article: Multi-Faceted Roles of Stress Granules in Viral Infection
Multi-Faceted Roles of Stress Granules in Viral Infection Open
Stress granules (SG), dynamic cytoplasmic condensates formed via liquid-liquid phase separation (LLPS), serve as a critical hub for cellular stress adaptation and antiviral defense. By halting non-essential translation and sequestering vir…
View article: Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus
Exploration of the Pathogenicity and Inflammatory Mechanism of Wuxiang Virus: A Newly Identified Phlebovirus Open
WUXV is phlebovirus transmitted by sandflies, which can cause death in suckling mice and infect humans and chickens. However, little is known about the pathogenicity and pathogenic mechanisms of animals. Therefore, BALB/c WT mice and BALB/…
View article: Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells
Mitofusin-Mediated Mitochondrial Fusion Inhibits Pseudorabies Virus Infection in Porcine Cells Open
Background: Mitochondria are highly dynamic organelles that undergo fusion/fission dynamics, and emerging evidence has established that mitochondrial dynamics plays a crucial regulatory role in the process of viral infection. Nevertheless,…
View article: Emergence and Characterization of Three Pseudorabies Variants with Moderate Pathogenicity in Growing Pigs
Emergence and Characterization of Three Pseudorabies Variants with Moderate Pathogenicity in Growing Pigs Open
Pseudorabies virus (PRV) remains a critical threat for the global swine industry, with heightened attention due to the emergence of variant strains since late 2011 in China. Emergent viral variants generally undergo three to four years of …
View article: Pseudorabies virus IE180 protein hijacks G3BPs into the nucleus to inhibit stress granule formation
Pseudorabies virus IE180 protein hijacks G3BPs into the nucleus to inhibit stress granule formation Open
Pseudorabies virus (PRV) is a porcine alphaherpesvirus that can infect different animal species and cause pruritus and lethal encephalitis. Stress granules (SGs) are membrane-free cytoplasmic structures formed by liquid-liquid phase separa…
View article: A Live-Attenuated Chimeric Vaccine Candidate Against the Emerging NADC34-Like PRRSV
A Live-Attenuated Chimeric Vaccine Candidate Against the Emerging NADC34-Like PRRSV Open
NADC34-like porcine reproductive and respiratory syndrome virus (PRRSV) has been circulating in China for several years, causing substantial economic losses to the local pig industry. Current commercial vaccines have failed to provide comp…
View article: Establishment and application of a triplex real-time PCR assay for detection of porcine circoviruses
Establishment and application of a triplex real-time PCR assay for detection of porcine circoviruses Open
Porcine circovirus disease represents a prevalent ailment that is principally manifested by a series of clinical symptoms, including reproductive disorders in sows and high mortality rates in piglets. It has brought huge economic losses up…
View article: Characterization of two neutralizing monoclonal antibodies with conformational epitopes against porcine deltacoronavirus
Characterization of two neutralizing monoclonal antibodies with conformational epitopes against porcine deltacoronavirus Open
Porcine deltacoronavirus (PDCoV) is a globally distributed swine enteropathogenic virus that emerged in the last decade. A recent report of PDCoV infection in Haitian children also highlights potential public health implications. In this s…
View article: Distinct effects of glucocorticoid on pseudorabies virus infection in neuron-like and epithelial cells
Distinct effects of glucocorticoid on pseudorabies virus infection in neuron-like and epithelial cells Open
Pseudorabies virus (PRV) is a porcine neurotropic alphaherpesvirus that infects peripheral tissues of its host, spreads into the nervous system, and establishes a life-long latency in neuronal cells. During productive infection, PRV replic…
View article: Enhanced Porcine Reproductive and Respiratory Syndrome Virus Replication in Nsp4- or Nsp2-Overexpressed Marc-145 Cell Lines
Enhanced Porcine Reproductive and Respiratory Syndrome Virus Replication in Nsp4- or Nsp2-Overexpressed Marc-145 Cell Lines Open
Porcine reproductive and respiratory syndrome (PRRS) causes significant economic losses to the swine industry. The killed PRRSV vaccine has been reported to be safe and could elicit humoral responses. The killed PRRSV vaccine with a high v…
View article: Metagenomic Identification of a Novel Zoonotic Gemykibivirus in a Diarrheic Pig in China.
Metagenomic Identification of a Novel Zoonotic Gemykibivirus in a Diarrheic Pig in China. Open
Gemykibiviruses are circular, replication-associated protein (REP) encoding single-stranded DNA (ssDNA) viruses classified within the genus Gemykibivirus of the family Genomoviridae. In recent years, several gemykibiviruses have been detec…
View article: Development and Comparison of Indirect ELISAs for Detecting IgG and IgA Antibodies Against Major Structural Proteins of Porcine Deltacoronavirus With Virus Neutralization as a Benchmark
Development and Comparison of Indirect ELISAs for Detecting IgG and IgA Antibodies Against Major Structural Proteins of Porcine Deltacoronavirus With Virus Neutralization as a Benchmark Open
Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen that causes substantial economic losses in the global swine industry. Although neutralizing antibodies (NAbs) are a key indicator of vaccine efficacy, their diagnostic concor…
View article: Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer
Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer Open
Chemoresistance poses a critical obstacle in bladder cancer (BCa) treatment, and effective interventions are currently limited. Elevated oxidative phosphorylation (OXPHOS) has been linked to cancer stemness, a determinant of chemoresistanc…
View article: PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection
PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection Open
Pseudorabies virus (PRV) poses a significant threat to the global swine industry, characterized by high morbidity and a range of sequelae in infected pigs. Mitochondria serve as a crucial platform for innate immunity, playing a pivotal rol…
View article: A 44-minute periodic radio transient in a supernova remnant
A 44-minute periodic radio transient in a supernova remnant Open
Long-period radio transients (LPTs) are a newly discovered class of radio emitters with yet incomprehensibly long rotation periods, ranging from minutes to hours. The astrophysical nature of their isolated counterparts remains undetermined…
View article: Ecological features and insecticide resistance of <i>Aedes albopictus</i> in Xi’an, a high-risk dengue transmission area in China
Ecological features and insecticide resistance of <i>Aedes albopictus</i> in Xi’an, a high-risk dengue transmission area in China Open
Background Dengue, a mosquito-borne viral disease, has occurred in many cities in China, and it tends to spread to higher latitudes (Huang et al., 2023). Xi’an, situated in central-west China, has witnessed an increase imported cases in th…
View article: Isolation, Genomic Characterization and Evolution of Six Porcine Rotavirus A Strains in a Pig Farming Group
Isolation, Genomic Characterization and Evolution of Six Porcine Rotavirus A Strains in a Pig Farming Group Open
Porcine rotavirus (PoRV) is a significant enteric pathogen causing gastroenteritis in piglets, which causes huge economic loss to the Chinese pig industry. In this study, six porcine rotavirus A strains were isolated from three adjacent so…
View article: Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication
Pseudorabies virus infection triggers mitophagy to dampen the interferon response and promote viral replication Open
Pseudorabies virus (PRV) utilizes multiple strategies to inhibit type I interferon (IFN-I) production and signaling to achieve innate immune evasion. Among several other functions, mitochondria serve as a crucial immune hub in the initiati…
View article: Dual roles of AtNBR1 in regulating selective autophagy <i>via</i> liquid-liquid phase separation and recognition of non-ubiquitinated substrates in Arabidopsis
Dual roles of AtNBR1 in regulating selective autophagy <i>via</i> liquid-liquid phase separation and recognition of non-ubiquitinated substrates in Arabidopsis Open
Selective macroautophagy/autophagy in metazoans involves the conserved receptors NBR1 and SQSTM1/p62. Both autophagy receptors manage ubiquitinated cargo recognition, while SQSTM1 has an additional, distinct role of facilitating liquid-liq…