Yanli Zhang
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View article: Effect of a goal-directed composite insulation scheme on perioperative elderly patients undergoing laparoscopic colorectal cancer surgery: study protocol for a randomized controlled trial
Effect of a goal-directed composite insulation scheme on perioperative elderly patients undergoing laparoscopic colorectal cancer surgery: study protocol for a randomized controlled trial Open
Chinese Clinical Trial Registry (https://www.chictr.org.cn/) ChiCTR2400088729. Registered in August, 2024. This trial is a prospective registry with the following registry names: Construction and application of perioperative goal-oriented …
View article: ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE
ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE Open
Th17 cells and interleukin-17A (IL-17A) drive the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Although myeloid-derived suppressor cells (MDSCs) promote the differentiation of Th17 cells, the epigenetic mech…
View article: SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis
SHLP2 alleviates allergic asthma by inhibiting ETV5/GSDMD signaling pathway-mediated pyroptosis Open
Overexpression of ETV5 improved mitochondrial function and reduced pyroptosis in bronchial epithelial cells. However, exogenous SHLP2 supplementation failed to reverse the exacerbation of HDM-induced lung inflammation and airway barrier da…
View article: Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation
Correction: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation Open
[This corrects the article DOI: 10.3389/fnmol.2025.1617543.].
View article: Treatment‐free remission in chronic myeloid leukaemia patients with accelerated phase or tyrosine kinase inhibitor therapy failure
Treatment‐free remission in chronic myeloid leukaemia patients with accelerated phase or tyrosine kinase inhibitor therapy failure Open
Summary We studied 60 chronic myeloid leukaemia (CML) patients with a prior history of accelerated phase (AP) including de novo AP ( n = 19) and transformation to AP ( n = 4), or tyrosine kinase inhibitor (TKI) therapy failure in the chron…
View article: S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation
S-9-PAHSA ameliorates cognitive decline in a type 2 diabetes mouse model by inhibiting oxidative stress and apoptosis via CAIII modulation Open
Purpose S-palmitic acid-9-hydroxy stearic acid (SP), a newly characterized endogenous lipid with multifaceted biological activities, is poised to shed light on its potential in diabetes-related cognitive disorder (DRCD). This study aims to…
View article: Characteristics of gastric fluid microbiota in patients with refractory Helicobacter pylori infection
Characteristics of gastric fluid microbiota in patients with refractory Helicobacter pylori infection Open
Introduction Refractory Helicobacter pylori infection (RHPI) poses a clinical challenge due to its treatment resistance. The gastric microbiota characteristics in patients with RHPI remain unclear. This study analyzed gastric fluid samples…
View article: S‐9‐<scp>PAHSA</scp> Protects Against High‐Fat Diet‐Induced Diabetes‐Associated Cognitive Impairment via Gut Microbiota Regulation
S‐9‐<span>PAHSA</span> Protects Against High‐Fat Diet‐Induced Diabetes‐Associated Cognitive Impairment via Gut Microbiota Regulation Open
Aim Diabetes‐associated cognitive impairment (DACI) is a common complication of Type 2 diabetes mellitus (T2DM), with its mechanisms and treatments for DACI remaining incompletely clarified. This study investigated the protective efficacy …
View article: Long non-coding RNA CYTOR promotes the progression of melanoma <i>via</i> the miR-485-5p/GPI axis
Long non-coding RNA CYTOR promotes the progression of melanoma <i>via</i> the miR-485-5p/GPI axis Open
Background Recent research has underscored the critical role of long non-coding RNAs (lncRNAs) in tumorigenesis and malignancy development. Nevertheless, the role of lncRNA cytoskeleton regulator RNA (CYTOR) in the progression of melanoma …
View article: Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae
Brain functional and structural alteration following acute carbon monoxide poisoning contribute to delayed neurological sequelae Open
The functional abnormalities in the visual- and sensory- cortex and PFC subsequent to acute CO poisoning represent one of the potential neural mechanisms underlying the occurrence of DNS.
View article: The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer
The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer Open
RNA splicing controls the post-transcriptional level of gene expression, allowing for the synthesis of many transcripts with various configurations and roles. Variations in RNA splicing regulatory factors, including splicing factors, signa…
View article: Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment
Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment Open
There were noticeable alterations in the aqueous humor of patients with wAMD involving many metabolites that are associated with ABC transporters, glycerophospholipid metabolism, and the mammalian target of rapamycin signaling pathway. It …
View article: Comprehensive antibiotic resistome comparison of Escherichia coli from irritable bowel syndrome and ulcerative colitis
Comprehensive antibiotic resistome comparison of Escherichia coli from irritable bowel syndrome and ulcerative colitis Open
The emergence of multidrug-resistant Escherichia coli (MDR E. coli), particularly enteropathogenic E. coli, is closely associated with therapeutic interventions for irritable bowel syndrome (IBS) and ulcerative colitis (UC) in clinical pra…
View article: Liquid–liquid phase separation in hepatocellular carcinoma
Liquid–liquid phase separation in hepatocellular carcinoma Open
Liquid-liquid phase separation (LLPS) drives the formation of membraneless intracellular compartments within both cytoplasm and nucleus. These compartments can form distinct physicochemical environments, and in particular display different…
View article: Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma
Reciprocal tumor‐platelet interaction through the EPHB1‐EFNB1 axis in the liver metastatic niche promotes metastatic tumor outgrowth in pancreatic ductal adenocarcinoma Open
Background The interaction between the metastatic microenvironment and tumor cells plays an important role in metastatic tumor formation. Platelets play pivotal roles in hematogenous cancer metastasis through tumor cell‐platelet interactio…
View article: Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis
Alterations of the resting-state brain network connectivity and gray matter volume in patients with fibromyalgia in comparison to ankylosing spondylitis Open
Fibromyalgia (FM) and ankylosing spondylitis (AS) are both rheumatic diseases characterized by significant musculoskeletal pain. In this study, we investigated the differences of the resting-state network (RSN) connectivity and gray matter…
View article: Patient‐reported outcomes in adults with tyrosine kinase inhibitor‐resistant chronic myeloid leukemia receiving olverembatinib therapy
Patient‐reported outcomes in adults with tyrosine kinase inhibitor‐resistant chronic myeloid leukemia receiving olverembatinib therapy Open
Background The objective of this study was to assess patient‐reported outcomes (PROs), including health‐related quality of life (HRQoL) and anxiety and depression symptoms, and to identify associated variables in patients with tyrosine kin…
View article: Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus Open
Background Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to investigate SLE-pathogenic gut microbes and their potential mechanisms. Methods There were 134 healthy con…
View article: Combined Low-Dose TBI, Ivig, and DEX for Donor-Specific Antibody Desensitization in Haploidentical and Mmud Haematopoietic Stem Cell Transplantation： a Retrospective Multicenter Case-Control Study
Combined Low-Dose TBI, Ivig, and DEX for Donor-Specific Antibody Desensitization in Haploidentical and Mmud Haematopoietic Stem Cell Transplantation： a Retrospective Multicenter Case-Control Study Open
Donor-specific HLA antibodies (DSA) are the main cause of graft failure in patients receiving haploidentical hematopoietic stem cell transplantation (Haplo-HSCT) and mismatched unrelated-donor hematopoietic stem cell transplantation（MMUD-H…
View article: Predictive Models for Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
Predictive Models for Discontinuation of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Open
Background: Tyrosine Kinase Inhibitors (TKI) have revolutionized the treatment of chronic myeloid leukemia (CML) and significantly improved survival rates for most patients, allowing a near-normal life expectancy. Treatment-free remission …
View article: Nicorandil activates lkb1-ampk signaling pathway to ameliorate cardiac remodeling after myocardial ischemia/reperfusion injury by upregulating mt2
Nicorandil activates lkb1-ampk signaling pathway to ameliorate cardiac remodeling after myocardial ischemia/reperfusion injury by upregulating mt2 Open
Background Cardiomyocyte apoptosis is a crucial event underlying the development of cardiac abnormalities and dysfunction after myocardial ischemia reperfusion (MI/R) injury. A better understanding of the cell signaling pathways involved i…
View article: Cardiovascular adverse events associated with targeted therapies for multiple myeloma: a pharmacovigilance study
Cardiovascular adverse events associated with targeted therapies for multiple myeloma: a pharmacovigilance study Open
Introduction Multiple myeloma (MM) is a leading cause of hematopoietic cancer-related mortality, accounting for 20% of deaths. MM-targeted therapies have demonstrated efficacy, and since 2015, the United States Food and Drug Administration…
View article: The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management.
The Mechanisms and Application Value of Postbiotics in Caries Prevention and Management. Open
Dental caries, one of the most prevalent diseases globally, affects individuals throughout their lifetimes. Recently, researchers have increasingly focused on postbiotics for caries prevention. Postbiotics, comprising inanimate microorgani…