Zhimei Li
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View article: Establishment and characterization of a novel patient-derived TP63-rearranged anaplastic large-cell lymphoma model PTCL-S1
Establishment and characterization of a novel patient-derived TP63-rearranged anaplastic large-cell lymphoma model PTCL-S1 Open
Anaplastic large-cell lymphoma (ALCL) accounts for 15% of all peripheral T-cell lymphomas globally and can be further divided into subcategories, of which patients with ALK-negative ALCL have dismal prognosis and overall survival. We estab…
View article: Preclinical activity of brincidofovir in Peripheral T-cell and NK/T-cell Lymphoma
Preclinical activity of brincidofovir in Peripheral T-cell and NK/T-cell Lymphoma Open
Introduction: Brincidofovir (BCV) is a novel nucleoside phosphonate analogue with unique dual anti-viral and anti-tumor properties. Methods: Activity of BCV was evaluated in forty-four cell-line models, including T/NK-cell non-Hodgkin lymp…
View article: A comparative study on the detection and localization of interictal epileptiform discharges in magnetoencephalography using optically pumped magnetometers versus superconducting quantum interference devices
A comparative study on the detection and localization of interictal epileptiform discharges in magnetoencephalography using optically pumped magnetometers versus superconducting quantum interference devices Open
This real-world study demonstrated that OPM-MEG had comparable applicability in IED detection and source localization, compared with SQUID-MEG. Additionally, OPM-MEG performed better in terms of IED amplitude and SNR. Lower costs and user-…
View article: Multiomics characterization of breast angiosarcoma from an Asian cohort reveals enrichment for angiogenesis signaling pathway and tumor-infiltrating macrophages
Multiomics characterization of breast angiosarcoma from an Asian cohort reveals enrichment for angiogenesis signaling pathway and tumor-infiltrating macrophages Open
Introduction Recent epidemiological data suggests a rising incidence of breast angiosarcoma (AS-B) in the Western population, with over two-thirds related to irradiation or chronic lymphedema. However, unlike head and neck angiosarcoma (AS…
View article: Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling
Effects of RARα ligand binding domain mutations on breast fibroepithelial tumor function and signaling Open
View article: Batatasin-III protects cerebral vascular endothelium by regulating mitochondrial function and production of nitric oxide
Batatasin-III protects cerebral vascular endothelium by regulating mitochondrial function and production of nitric oxide Open
This study assessed the effect of batatasin-III on cerebral microvascular endothelial cell (EC) injury. Endothelial cell injury was induced in isolated cells by oxygenglucose deprivation/reperfusion (OGD/R) conditions. During 4 h of OGD in…
View article: The Impact of Government Innovation Subsidies on the Resilience of the Manufacturing Industry Chain
The Impact of Government Innovation Subsidies on the Resilience of the Manufacturing Industry Chain Open
View article: Whole genome sequencing of HER2-positive metastatic extramammary Paget’s disease: a case report
Whole genome sequencing of HER2-positive metastatic extramammary Paget’s disease: a case report Open
View article: Simulation Analysis of Influence of Accident Conditions on Hydraulic Reliability of Gas Pipe Network
Simulation Analysis of Influence of Accident Conditions on Hydraulic Reliability of Gas Pipe Network Open
Taking reliability as the starting point, based on Pipeline Studio software and combined with the actual situation of medium-pressure gas pipe network in Weidu District, Xuchang City, the operation conditions of gas pipe network under desi…
View article: Repurposing fluphenazine as an autophagy modulator for treating liver cancer
Repurposing fluphenazine as an autophagy modulator for treating liver cancer Open
View article: Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model
Establishment and characterization of a patient-derived solitary fibrous tumor/hemangiopericytoma cell line model Open
Solitary fibrous tumor/Hemangiopericytoma (SFT/HPC) is a rare subtype of soft tissue sarcoma harboring NAB2 - STAT6 gene fusions. Mechanistic studies and therapeutic development on SFT/HPC are impeded by scarcity and lack of system models.…
View article: Abnormal white matter structural network topological property in patients with temporal lobe epilepsy
Abnormal white matter structural network topological property in patients with temporal lobe epilepsy Open
Background Diffusion tensor imaging (DTI) studies have demonstrated white matter (WM) abnormalities in patients with temporal lobe epilepsy (TLE). However, alterations in the topological properties of the WM structural network in patients …
View article: Magnetoencephalography-based approaches to epilepsy classification
Magnetoencephalography-based approaches to epilepsy classification Open
Epilepsy is a chronic central nervous system disorder characterized by recurrent seizures. Not only does epilepsy severely affect the daily life of the patient, but the risk of premature death in patients with epilepsy is three times highe…
View article: Recycling/Production and Incentive-Penalty Strategies in Closed-Loop Supply Chains under Remanufacturing Policies
Recycling/Production and Incentive-Penalty Strategies in Closed-Loop Supply Chains under Remanufacturing Policies Open
In light of resource scarcity and environmental challenges, remanufacturing bolsters resource efficiency and fosters a circular economy, with policy support being pivotal for its development. Although previous studies have predominantly co…
View article: Table S1 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S1 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S1 - XLS file 316K, Supplementary table 1 shows the expression profiles of PDK1-regulated genes in HEK-Vector, -PDK1, -Myc and -E545K cells
View article: Figure S1-9; Supplementary methods from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Figure S1-9; Supplementary methods from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open
Supplementary methods. Supplementary Figures 1-9
View article: Table S3 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S3 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S3 - XLS file 71K, Supplementary table 3 shows the expression profiles of PIK3CA/E545K-regulated genes in HEK-Vector, -PDK1, -Myc and -E545K cells
View article: Figure S1-9; Supplementary methods from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Figure S1-9; Supplementary methods from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open
Supplementary methods. Supplementary Figures 1-9
View article: Table S3 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S3 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S3 - XLS file 71K, Supplementary table 3 shows the expression profiles of PIK3CA/E545K-regulated genes in HEK-Vector, -PDK1, -Myc and -E545K cells
View article: Table S2 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S2 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S2 - XLS file 203K, Supplementary table 2 shows the expression profiles of Myc-regulated genes in HEK-Vector, -PDK1, -Myc and -E545K cells
View article: Data from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Data from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Although 3-phosphoinositide–dependent protein kinase-1 (PDK1) has been predominately linked to the phosphoinositide 3-kinase (PI3K)–AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here, we report that …
View article: Tables S1-S16 from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Tables S1-S16 from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open
Supplementary tables
View article: Tables S1-S16 from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Tables S1-S16 from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open
Supplementary tables
View article: Table S4 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S4 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S4 - XLS file 55K, Supplementary table 4 shows the list of PDK1-regulated genes significantly different from Myc-regulated genes
View article: Data from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Data from <i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma Open
Protein-coding mutations in clear cell renal cell carcinoma (ccRCC) have been extensively characterized, frequently involving inactivation of the von Hippel–Lindau (VHL) tumor suppressor. Roles for noncoding cis-regulatory ab…
View article: Table S4 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S4 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S4 - XLS file 55K, Supplementary table 4 shows the list of PDK1-regulated genes significantly different from Myc-regulated genes
View article: Table S2 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy
Table S2 from PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy Open
Table S2 - XLS file 203K, Supplementary table 2 shows the expression profiles of Myc-regulated genes in HEK-Vector, -PDK1, -Myc and -E545K cells
View article: Correction: Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer
Correction: Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer Open
In the original version of this article (1), Duane T. Smoot and Hassan Ashktorab are mistakenly omitted from the author list. This error has been corrected in the latest online HTML and PDF versions of the article and the author contributi…
View article: Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide
Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide Open
Background Natural killer/T-cell lymphoma (NKTL) is a rare type of aggressive and heterogeneous non-Hodgkin's lymphoma (NHL) with a poor prognosis and limited therapeutic options. Therefore, there is an urgent need to exploit potential nov…
View article: Additional file 2 of Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide
Additional file 2 of Aberrant JAK-STAT signaling-mediated chromatin remodeling impairs the sensitivity of NK/T-cell lymphoma to chidamide Open
Additional file 2. Tables S1-10. Table S1. List of primers used for ChIP-qPCR. Table S2. List of primers used for RT–qPCR. Table S3. Demographic and clinical characteristics of the 28 relapsed/refractory NKTL patients. Table S4. Patient ch…