Liam E. Potter
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View article: Bidirectional modulation of accumbens dopamine by MCH neurons during learning and consummatory behavior
Bidirectional modulation of accumbens dopamine by MCH neurons during learning and consummatory behavior Open
The formation of sensory cue-reward associations is essential for survival, but in the modern calorie-rich and advertising-intensive environment, such associations may become maladaptive - leading to negative health consequences such as ob…
View article: The melanin-concentrating hormone system as a target for the treatment of sleep disorders
The melanin-concentrating hormone system as a target for the treatment of sleep disorders Open
Given the widespread prevalence of sleep disorders and their impacts on health, it is critical that researchers continue to identify and evaluate novel avenues of treatment. Recently the melanin-concentrating hormone (MCH) system has attra…
View article: Experimenter sex modulates mouse biobehavioural and pharmacological responses
Experimenter sex modulates mouse biobehavioural and pharmacological responses Open
Differential rodent responses to the sex of human experimenters could have far reaching consequences in preclinical studies. Here, we show that the sex of human experimenters affects mouse behaviours and responses to the rapid-acting antid…
View article: Estradiol mediates stress-susceptibility in the male brain
Estradiol mediates stress-susceptibility in the male brain Open
In susceptible populations, stress is a major risk factor for the development of mental disorders, including depression. Estradiol, often considered a female hormone, is distributed in the male brain via aromatization of testosterone. The …
View article: Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzine
Central nervous system plasticity associated with pain in a mouse model of multiple sclerosis, and the antinociceptive effects of the antidepressant phenelzine Open
Multiple sclerosis (MS) is a chronic, progressive disease that involves neuroinflammation, demyelination, and neurodegeneration within the central nervous system (CNS). While loss of motor function and paralysis are considered the primary …
View article: Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis
Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis Open
These findings implicate a pro-excitatory shift in the E-I balance of the somatosensory CNS, arising early in the pathogenesis EAE and leading to large-scale functional and structural plasticity in S1. They also suggest a novel antinocicep…