Liam Golding
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View article: Chronic health consequences of the COVID-19 pandemic on school workers: a cross-sectional post-pandemic analysis
Chronic health consequences of the COVID-19 pandemic on school workers: a cross-sectional post-pandemic analysis Open
Importance The COVID-19 pandemic dramatically affected schools. However, there are insufficient data on the chronic physical and mental health consequences of the pandemic in school workers. Objectives To determine the prevalence and the f…
View article: Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease
Durability of Antibody Responses to SARS-CoV-2 Vaccination over 12 Months in Pediatric Inflammatory Bowel Disease Open
Background/Objectives: Severe acute respiratory syndrome (SARS-CoV-2) has had a profound global impact and continues to represent a health challenge worldwide. The durability of SARS-CoV-2 vaccine responses in pediatric inflammatory bowel …
View article: STAT6 gain-of-function disease: p.D519N is a new disease-causing variant that responds well to dupilumab treatment
STAT6 gain-of-function disease: p.D519N is a new disease-causing variant that responds well to dupilumab treatment Open
This case report presents a new genetic variant that causes STAT6 gain-of-function disease in 2 patients, expands the clinical phenotype of STAT6 gain-of-function disease, and describes its authors' success in using therapeutics to manage …
View article: OTULIN Haploinsufficiency Caused by a Novel Splice Acceptor Variant
OTULIN Haploinsufficiency Caused by a Novel Splice Acceptor Variant Open
Inborn errors of immunity (IEIs) represent a diverse group of genetic disorders that compromise immune function, leading to susceptibility to infections and immune dysregulation. Biallelic and heterozygous loss-of-function variants in OTUL…
View article: Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections
Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections Open
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)–specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV ant…
View article: Risk of Reinfection and Incidence of Chronic Symptoms After SARS-CoV-2 Infections
Risk of Reinfection and Incidence of Chronic Symptoms After SARS-CoV-2 Infections Open
This study showed that a severe acute respiratory syndrome coronavirus 2 infection reduced the risk of reinfection among vaccinated individuals by 0.50 (95% CI, 0.39–0.64) over a 1-year period, after accounting for unreported infections us…
View article: A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis
A multimorphic variant in ThPOK causes a novel human disease characterized by T cell abnormalities, immunodysregulation, allergy, and fibrosis Open
ThPOK is best known as a regulator of CD4+ T cell lineage commitment, although it was initially cloned as a suppressor of collagen expression in the skin. The role of ThPOK has not been formally established in humans since individuals with…
View article: A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections
A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections Open
Detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections is challenging with current serology assays and is further complicated by the marked decrease in routine viral testing practices as viral transmission incr…
View article: DDIT4L regulates mitochondrial and innate immune activities in early life
DDIT4L regulates mitochondrial and innate immune activities in early life Open
Pattern recognition receptor responses are profoundly attenuated before the third trimester of gestation in the relatively low-oxygen human fetal environment. However, the mechanisms regulating these responses are uncharacterized. Herein, …
View article: Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures
Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures Open
Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions in women of childbearing age in 2020-2021…
View article: Loss of severe respiratory syncytial virus infection-associated antibody function during the peak of the COVID-19 pandemic mitigation measures
Loss of severe respiratory syncytial virus infection-associated antibody function during the peak of the COVID-19 pandemic mitigation measures Open
Studies have linked reduced respiratory syncytial virus-specific Fc-mediated phagocytic function and complement deposition to more severe infection. This study shows a loss of these functions during the first year of COVID-19 pandemic. The…
View article: Determining the Optimal SARS-CoV-2 mRNA Vaccine Dosing Interval for Maximum Immunogenicity
Determining the Optimal SARS-CoV-2 mRNA Vaccine Dosing Interval for Maximum Immunogenicity Open
Objective: Emerging evidence indicates that longer SARS-CoV-2 vaccine dosing intervals results in an enhanced immune response. However, the optimal vaccine dosing interval for achieving maximum immunogenicity is unclear. Methods: This stud…
View article: Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals
Correlation of SARS-CoV-2 Viral Neutralizing Antibody Titers with Anti-Spike Antibodies and ACE-2 Inhibition among Vaccinated Individuals Open
Live viral neutralizing antibody titers are an accepted measure of immunity; however, testing procedures are labor-intensive. COVID-19 antibody and angiotensin converting enzyme-2 (ACE-2) levels have been used as surrogates to live viral n…
View article: Variability in mRNA SARS-CoV-2 BNT162b2 vaccine immunogenicity is associated with differences in the gut microbiome and habitual dietary fibre intake
Variability in mRNA SARS-CoV-2 BNT162b2 vaccine immunogenicity is associated with differences in the gut microbiome and habitual dietary fibre intake Open
Objective Little is known about the interplay between gut microbiome and SARS-CoV-2 vaccine immunogenicity. In this prospective observational study, we investigated associations between the gut microbiome, habitual dietary fibre intake, an…
View article: Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic
Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic Open
Health jurisdictions have seen a near-disappearance of respiratory syncytial virus (RSV) during the first year of the coronavirus disease 2019 (COVID-19) pandemic. Over this corresponding period, we report a reduction in RSV antibody level…
View article: Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273
Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273 Open
The BNT162b2 and mRNA-1273 mRNA SARS-CoV-2 vaccines have demonstrated high efficacy for preventing short-term COVID-19. However, comparative long-term effectiveness is unclear, especially pertaining to the Delta variant.
View article: Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity
Determining the optimal SARS-CoV-2 mRNA vaccine dosing interval for maximum immunogenicity Open
Objective Emerging evidence indicates that longer SARS-CoV-2 vaccine dosing intervals results in an enhanced immune response. However, the optimal vaccine dosing interval for achieving maximum immunogenicity is unclear. Methods This study …
View article: Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals
Immunogenicity of Extended mRNA SARS-CoV-2 Vaccine Dosing Intervals Open
This study investigates the immunogenicity of extended mRNA vaccine dosing intervals.