Lee A. Hebert
YOU?
Author Swipe
View article: Characterization of the Porcine Cingulate Sulcus Cytoarchitecture
Characterization of the Porcine Cingulate Sulcus Cytoarchitecture Open
Cortical folding (gyrification) is a unique process by which the brain can expand and increase surface area while confined by the boundaries of the inner wall of the skull. Although there is still much debate about the exact mechanisms con…
View article: Beyond Retrieval: Generating Narratives in Conversational Recommender Systems
Beyond Retrieval: Generating Narratives in Conversational Recommender Systems Open
The recent advances in Large Language Model's generation and reasoning capabilities present an opportunity to develop truly conversational recommendation systems. However, effectively integrating recommender system knowledge into LLMs for …
View article: FLARE: Fusing Language Models and Collaborative Architectures for Recommender Enhancement
FLARE: Fusing Language Models and Collaborative Architectures for Recommender Enhancement Open
Recent proposals in recommender systems represent items with their textual description, using a large language model. They show better results on standard benchmarks compared to an item ID-only model, such as Bert4Rec. In this work, we rev…
View article: PERSOMA: PERsonalized SOft ProMpt Adapter Architecture for Personalized Language Prompting
PERSOMA: PERsonalized SOft ProMpt Adapter Architecture for Personalized Language Prompting Open
Understanding the nuances of a user's extensive interaction history is key to building accurate and personalized natural language systems that can adapt to evolving user preferences. To address this, we introduce PERSOMA, Personalized Soft…
View article: Rituximab or cyclosporine A for the treatment of membranous nephropathy: economic evaluation of the MENTOR trial
Rituximab or cyclosporine A for the treatment of membranous nephropathy: economic evaluation of the MENTOR trial Open
Background and hypothesis The MENTOR trial (MEmbranous Nephropathy Trial Of Rituximab) showed that rituximab was noninferior to cyclosporine in inducing complete or partial remission of proteinuria and was superior in maintaining proteinur…
View article: The classification of glomerulonephritis in systemic lupus erythematosus revisited
The classification of glomerulonephritis in systemic lupus erythematosus revisited Open
The classification of glomerulonephritis in systemic lupus erythematosus revisited.The currently used classification reflects our understanding of the pathogenesis of the various forms of lupus nephritis, but clinicopathologic studies have…
View article: The Influence of an Elastase-Sensitive Complement C5 Variant on Lupus Nephritis and Its Flare
The Influence of an Elastase-Sensitive Complement C5 Variant on Lupus Nephritis and Its Flare Open
The C5 2404-G allele/GG genotype is a potential risk factor for LN uniquely in black lupus patients. The GG genotype is associated with sharp increases in urine C5a and MAC levels in a subset of LN flares that correspond to higher LN disea…
View article: Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans
Gene Copy-Number Variation and Associated Polymorphisms of Complement Component C4 in Human Systemic Lupus Erythematosus (SLE): Low Copy Number Is a Risk Factor for and High Copy Number Is a Protective Factor against SLE Susceptibility in European Americans Open
Interindividual gene copy-number variation (CNV) of complement component C4 and its associated polymorphisms in gene size (long and short) and protein isotypes (C4A and C4B) probably lead to different susceptibilities to autoimmune disease…
View article: End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1
End-Stage Renal Disease in African Americans With Lupus Nephritis Is Associated With APOL1 Open
Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN is more prevalent among African Americans than among European Am…
View article: Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy
Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy Open
Rituximab was noninferior to cyclosporine in inducing complete or partial remission of proteinuria at 12 months and was superior in maintaining proteinuria remission up to 24 months. (Funded by Genentech and the Fulk Family Foundation; MEN…
View article: Anti−PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1
Anti−PD-1 Immunotherapy May Induce Interstitial Nephritis With Increased Tubular Epithelial Expression of PD-L1 Open
We propose that immunohistochemistry with PD-L1 could be a useful tool to differentiate AIN associated with anti-PD-1 therapy from other AINs.
View article: Anticoagulant-Related Nephropathy
Anticoagulant-Related Nephropathy Open
Anticoagulant-related nephropathy (ARN) is a newly recognized form of AKI in which overanticoagulation causes profuse glomerular hemorrhage, which manifests on renal biopsy as numerous renal tubules filled with red cells and red cell casts…
View article: Acute kidney injury aggravated by treatment initiation with apixaban: Another twist of anticoagulant-related nephropathy
Acute kidney injury aggravated by treatment initiation with apixaban: Another twist of anticoagulant-related nephropathy Open
Anticoagulant-related nephropathy (ARN) was initially described in patients on warfarin (as warfarin-related nephropathy) and recently in those using dabigatran. Herein, we report clinical history and kidney biopsy findings in a patient on…
View article: The Urine Preservative Acetic Acid Degrades Urine Protein: Implications for Urine Biorepositories and the AASK Cohort Study
The Urine Preservative Acetic Acid Degrades Urine Protein: Implications for Urine Biorepositories and the AASK Cohort Study Open
Patients enrolled in the African American Study of Kidney Disease and Hypertension (AASK) Cohort Study who exhibited overt proteinuria have been reported to show high nonalbumin proteinuria (NAP), which is characteristic of a tubulopathy. …
View article: The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data
The Severity of Intracranial Hemorrhages Measured by Free Hemoglobin in the Brain Depends on the Anticoagulant Class: Experimental Data Open
Background and Purpose. Anticoagulant therapy is broadly used to prevent thromboembolic events. Intracranial hemorrhages are serious complications of anticoagulation, especially with warfarin. Direct oral anticoagulants reduce but do not e…
View article: Staphylococcus Infection–Associated GN – Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort
Staphylococcus Infection–Associated GN – Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort Open
Background and objectives Staphylococcus infection–associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resembl…
View article: Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases
Early Components of the Complement Classical Activation Pathway in Human Systemic Autoimmune Diseases Open
The complement system consists of effector proteins, regulators, and receptors that participate in host defense against pathogens. Activation of the complement system, via the classical pathway (CP), has long been recognized in immune comp…
View article: Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare
Relationship of Circulating Anti-C3b and Anti-C1q IgG to Lupus Nephritis and Its Flare Open
Although not as prevalent as anti-C1q IgG, anti-C3b IgG showed nearly complete specificity for lupus nephritis. The presence of anti-C3b IgG identified patients with lupus nephritis who were prone to flare and in whom serial measurements o…
View article: Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning
Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning Open
Introduction: Brodifacoum (BDF) is a superwarfarin that is used primarily as a rodenticide. There have been increasing numbers of reports of human cases of accidental or intentional BDF ingestion with high mortality rate. Its broad availab…