Explanipedia

Teeth outside the mouth: The evolution and development of shark denticles Open

Rory L. Cooper, Ella F. Nicklin, Liam J. Rasch, Gareth J. Fraser · 2023

Vertebrate skin appendages are incredibly diverse. This diversity, which includes structures such as scales, feathers, and hair, likely evolved from a shared anatomical placode, suggesting broad conservation of the early development of the…

Teeth outside the mouth: the evolution and development of shark denticles Open

Rory L. Cooper, Ella F. Nicklin, Liam J. Rasch, Gareth J. Fraser · 2022

Vertebrate skin appendages are incredibly diverse. This diversity, which includes structures such as scales, feathers, and hair, likely evolved from a shared anatomical placode, suggesting broad conservation of the early development of the…

Development and regeneration of the crushing dentition in skates (Rajidae) Open

Liam J. Rasch, Rory L. Cooper, Charlie J. Underwood, Wesley A. Dillard, Alexandre P Thiery , et al. · 2020

An ancient Turing-like patterning mechanism regulates skin denticle development in sharks Open

Rory L. Cooper, Alexandre P Thiery, Alexander G. Fletcher, Daniel J. Delbarre, Liam J. Rasch , et al. · 2018

Diverse skin appendages, from shark denticles to bird feathers, develop via a conserved and ancient Turing patterning mechanism.

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy Open

Robert Fledrich, Tamer A. Abdelaal, Liam J. Rasch, V. Bansal, Vlad Schütza , et al. · 2018

Developing an ancient epithelial appendage: FGF signalling regulates early tail denticle formation in sharks Open

Rory L. Cooper, Kyle J. Martin, Liam J. Rasch, Gareth J. Fraser · 2017

Overall, these findings suggest the core GRN for building vertebrate integumentary epithelial appendages has been highly conserved over 450 million years. This provides evidence for the continuous, historical homology of epithelial appenda…

Sox2+ progenitors in sharks link taste development with the evolution of regenerative teeth from denticles Open

Kyle J. Martin, Liam J. Rasch, Rory L. Cooper, Brian Metscher, Zerina Johanson , et al. · 2016

Significance Oral teeth and skin denticles share a deep, 450-million-year-old, evolutionary relationship among vertebrates. We investigate how teeth evolved from simpler denticles using sharks as an evolutionary developmental model. The st…

An ancient dental gene set governs development and continuous regeneration of teeth in sharks Open

Liam J. Rasch, Kyle J. Martin, Rory L. Cooper, Brian Metscher, Charlie J. Underwood , et al. · 2016

The evolution of oral teeth is considered a major contributor to the overall success of jawed vertebrates. This is especially apparent in cartilaginous fishes including sharks and rays, which develop elaborate arrays of highly specialized …

Development and Evolution of Dentition Pattern and Tooth Order in the Skates And Rays (Batoidea; Chondrichthyes) Open

Charlie J. Underwood, Zerina Johanson, Monique Welten, Brian Metscher, Liam J. Rasch , et al. · 2015

Shark and ray (elasmobranch) dentitions are well known for their multiple generations of teeth, with isolated teeth being common in the fossil record. However, how the diverse dentitions characteristic of elasmobranchs form is still poorly…

AN ANCESTRAL GENE NETWORK REGULATES CONTINUOUS TOOTH REGENERATION AND DENTICLE DEVELOPMENT IN ELASMOBRANCHS Open

Liam J. Rasch · 2015

Sharks and rays (elasmobranchs) regenerate their teeth via a novel system in which multiple teeth develop in advance of function as a dental conveyor belt. Given their ancestral phylogenetic position, extant elasmobranchs therefore provide…

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