Lawrence Rice
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View article: Congenital Hemolytic Anemias Presenting As Severe Anemia in Older Patients
Congenital Hemolytic Anemias Presenting As Severe Anemia in Older Patients Open
Mild congenital hemolytic anemias can become worse with aging and co-morbidities. We currently care for four patients in whom we established the diagnosis of Hereditary Spherocytosis (HS) or Hereditary Elliptocytosis (HE) after age 70. All…
View article: Survival After Ruptured Spontaneous Hepatic Subcapsular Hematoma Following Heparin Initiation for Submassive Pulmonary Embolism
Survival After Ruptured Spontaneous Hepatic Subcapsular Hematoma Following Heparin Initiation for Submassive Pulmonary Embolism Open
Hepatic subcapsular hematomas (HSHs) are rare outside the context of trauma, endoscopic retrograde cholangiopancreatography, and pregnancy. Ruptured HSHs present with abdominal pain and hypotension, with high mortality. We present the pati…
View article: Neocytolysis on descending the mountain and ascending into space
Neocytolysis on descending the mountain and ascending into space Open
So is science - just a few years ago one of us1 co-authors an editorial on a phenomenon of the destruction of young red blood cells outside the bone marrow in the circulating blood, named neocytolysis by Alfrey et al.2, 3 Now, a new study …
View article: Issue Information
Issue Information Open
It is time to adopt a multicolor immunophenotyping approach to evaluate blood for Sézary syndrome and mycosis fungoides
View article: Reactive <scp>NK</scp> cell lymphocytosis with atypical immunophenotype in a chronic <scp>HIV</scp>‐infected patient
Reactive <span>NK</span> cell lymphocytosis with atypical immunophenotype in a chronic <span>HIV</span>‐infected patient Open
Reactive natural killer (NK) cells may show an altered immunophenotype under certain conditions, such as viral infections or in association with non-NK cell hematopoietic neoplasms. Such conditions can result in the immunophenotype of reac…
View article: Acute myeloid leukaemia presenting as acute liver failure—a case report and literature review
Acute myeloid leukaemia presenting as acute liver failure—a case report and literature review Open
A 75-year-old woman presented with rapidly progressive fatigue, abdominal pain and jaundice. Physical examination revealed tender abdomen and splenomegaly. Magnetic resonance cholangiogram showed marked hepatomegaly, splenomegaly and scatt…
View article: Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH)
Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH) Open
Autosplenectomy (AS) is a known complication of diseases such as sickle cell anemia, celiac disease, and inflammatory bowel disease. We report the first known case of AS due to paroxysmal nocturnal hemoglobinuria (PNH). A 24-year-old Cauca…
View article: Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia
Prospective comparison of the HEP score and 4Ts score for the diagnosis of heparin-induced thrombocytopenia Open
The HIT Expert Probability (HEP) score compared favorably with the 4Ts score in a retrospective study. We assessed the diagnostic accuracy of the HEP score compared with the 4Ts score in a prospective cohort of 310 patients with suspected …
View article: HITs and misses in 100 years of heparin
HITs and misses in 100 years of heparin Open
Heparin was discovered 100 years ago, and the heparin-induced thrombocytopenia syndrome was described 40 years ago. That the most powerful anticoagulant of the last century can also produce the most extreme prothrombotic diathesis is but o…
View article: Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura Open
Key Points First-in-human, phase 1 study, recombinant ADAMTS-13 was safe, nonimmunogenic, and tolerated in congenital thrombotic thrombocytopenic purpura. Recombinant ADAMTS-13 pharmacokinetic profile was comparable to plasma infusion stud…
View article: A need for a systematic genetic evaluation of hereditary polyuric patients
A need for a systematic genetic evaluation of hereditary polyuric patients Open
In this issue of CKJ, Wong et al. [1] present a 44-year-old patient with life-long polyuria and polydipsia, a presumed diagnosis of autosomal dominant nephrogenic diabetes insipidus (NDI), progressive dilation of the urinary tract and obst…