Lisa Sweeney
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View article: Toxicokinetic Modeling of Per- and Polyfluoroalkyl Substance Concentrations within Developing Zebrafish (<i>Danio rerio</i>) Populations
Toxicokinetic Modeling of Per- and Polyfluoroalkyl Substance Concentrations within Developing Zebrafish (<i>Danio rerio</i>) Populations Open
Per- and polyfluoroalkyl substances (PFAS) are pervasive environmental contaminants, and their relative stability and high bioaccumulation potential create a challenging risk assessment problem. Zebrafish (Danio rerio) data, in principle, …
View article: IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making Open
During the past few decades, the science of toxicology has been undergoing a transformation from observational to predictive science. New approach methodologies (NAMs), including in vitro assays, in silico models, read-across, and in vitro…
View article: Considerations for Development of Exposure Limits for Chemicals Encountered During Aircraft Operation
Considerations for Development of Exposure Limits for Chemicals Encountered During Aircraft Operation Open
Background Military aircrews’ health status is critical to their mission readiness, as they perform physically and cognitively demanding tasks in nontraditional work environments. Research Objectives: Our objective is to develop a broad op…
View article: Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation
Advances in Inhalation Dosimetry Models and Methods for Occupational Risk Assessment and Exposure Limit Derivation Open
The purpose of this article is to provide an overview and practical guide to occupational health professionals concerning the derivation and use of dose estimates in risk assessment for development of occupational exposure limits (OELs) fo…
View article: Toxicokinetic Model Development for the Insensitive Munitions Component 3-Nitro-1,2,4-Triazol-5-One
Toxicokinetic Model Development for the Insensitive Munitions Component 3-Nitro-1,2,4-Triazol-5-One Open
3-Nitro-1,2,4-triazol-5-one (NTO) is a component of insensitive munitions that are potential replacements for conventional explosives. Toxicokinetic data can aid in the interpretation of toxicity studies and interspecies extrapolation, but…
View article: Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4)
Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4) Open
Potential chronic health risks for children and prospective parents exposed to ethylbenzene were evaluated in response to the Voluntary Children's Chemical Evaluation Program. Ethylbenzene exposure was found to be predominately via inhalat…