Liam Weaver
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Electronic nose differentiates pre- and postchallenge samples in an induced bovine respiratory disease model Open
Bovine respiratory disease (BRD) is the most common disease challenge in feedlot cattle. Visual observation, with or without body temperature, continues to be the standard method of BRD diagnosis, although previous studies have shown a po…
View article: Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: A computational study
Airway pressures generated by high flow nasal cannula in patients with acute hypoxemic respiratory failure: A computational study Open
Introduction and Objectives: High flow nasal cannula (HFNC) therapy is an increasingly popular mode of non-invasive respiratory support for the treatment of patients with acute hypoxemic respiratory failure (AHRF). Previous experimental st…
View article: Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation
Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation Open
OBJECTIVES: To clarify the mechanistic basis for the success or failure of noninvasive ventilation (NIV) in acute hypoxemic respiratory failure (AHRF). DESIGN: We created digital twins based on mechanistic computational models of individua…
Correction and standardisation of lung oscillometry techniques using parameter inference: A study group report Open
This report relates to a study group hosted by the EPSRC funded network, Integrating data-driven BIOphysical models into REspiratory MEdicine (BIOREME), and supported by The Insigneo Institute and The Knowledge Transfer Network. The BIOREM…
Positive end expiratory pressure in invasive and non-invasive ventilation of COVID-19 acute respiratory distress syndrome: computational modeling illuminates the data Open
Positive end expiratory pressure (PEEP) is routinely used as part of lung protective ventilation strategies in the treatment of acute respiratory distress syndrome (ARDS). In the case of ARDS arising due to COVID-19 (CARDS), there is some …
High risk of patient self-inflicted lung injury in COVID-19 with frequently encountered spontaneous breathing patterns: a computational modelling study Open
Background There is on-going controversy regarding the potential for increased respiratory effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing patients with COVID-19 acute hypoxaemic respiratory failur…