Lian Ni Lee
YOU?
Author Swipe
View article: 635 A randomised, placebo-controlled, phase I/IIa study evaluating the safety and clinical activity of a novel cancer vaccine (ITOP1) in patients with resectable oesophageal adenocarcinoma (VISTA study)
635 A randomised, placebo-controlled, phase I/IIa study evaluating the safety and clinical activity of a novel cancer vaccine (ITOP1) in patients with resectable oesophageal adenocarcinoma (VISTA study) Open
View article: 1427 Precision Immunomics<sup>TM</sup>: identification of hundreds of novel cancer antigens using a sensitive immunopeptidomics-led platform
1427 Precision Immunomics<sup>TM</sup>: identification of hundreds of novel cancer antigens using a sensitive immunopeptidomics-led platform Open
View article: 1039 Vaccination with a single dose of a novel delivery platform confers durable >8 month immune responses, with lasting protection against tumour and metastases in preclinical models
1039 Vaccination with a single dose of a novel delivery platform confers durable >8 month immune responses, with lasting protection against tumour and metastases in preclinical models Open
View article: Unlocking cancer vaccine potential: What are the key factors?
Unlocking cancer vaccine potential: What are the key factors? Open
Cancer is a global health challenge, with changing demographics and lifestyle factors producing an increasing burden worldwide. Screening advancements are enabling earlier diagnoses, but current cancer immunotherapies only induce remission…
View article: Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response Open
Protein arginine methyltransferase (PRMT) 5 is over-expressed in a variety of cancers and the master transcription regulator E2F1 is an important methylation target. We have explored the role of PRMT5 and E2F1 in regulating the non-coding …
View article: The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity
The HDAC inhibitor zabadinostat is a systemic regulator of adaptive immunity Open
Protein acetylation plays a key role in regulating cellular processes and is subject to aberrant control in diverse pathologies. Although histone deacetylase (HDAC) inhibitors are approved drugs for certain cancers, it is not known whether…
View article: Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors
Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors Open
Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. They generate concerted innate and adaptive immune response, and robust CD8 + T cell responses. We engineered a non-replicating pseudotyped inf…
View article: Author response: Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors
Author response: Recombinant single-cycle influenza virus with exchangeable pseudotypes allows repeated immunization to augment anti-tumour immunity with immune checkpoint inhibitors Open
View article: Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses Open
The role of immune responses to previously seen endemic coronavirus epitopes in severe acute respiratory coronavirus 2 (SARS-CoV-2) infection and disease progression has not yet been determined. Here, we show that a key characteristic of f…
View article: Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern Open
View article: Recombinant single-cycle influenza virus as a new tool to augment antitumour immunity with immune checkpoint inhibitors
Recombinant single-cycle influenza virus as a new tool to augment antitumour immunity with immune checkpoint inhibitors Open
Virus-based tumour vaccines offer many advantages compared to other antigen delivering systems. They generate concerted innate and adaptive immune response, and robust CD8 + T cell responses. We engineered a non-replicating pseudotyped inf…
View article: Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses
Fatal COVID-19 outcomes are associated with an antibody response targeting epitopes shared with endemic coronaviruses Open
Summary It is unclear whether prior endemic coronavirus infections affect COVID-19 severity. Here, we show that in cases of fatal COVID-19, antibody responses to the SARS-COV-2 spike are directed against epitopes shared with endemic beta-c…
View article: T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses Open
View article: Editorial: Memory T Cells in Chronic Infections and Tumors
Editorial: Memory T Cells in Chronic Infections and Tumors Open
EDITORIAL article Front. Immunol., 17 February 2021Sec. Immunological Memory Volume 12 - 2021 | https://doi.org/10.3389/fimmu.2021.656010
View article: Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses
Fatal COVID-19 Outcomes are Associated with an Antibody Response Targeting Epitopes Shared with Endemic Coronaviruses Open
View article: Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer
Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer Open
Background Adenoviral vectors emerged as important platforms for cancer immunotherapy. Vaccination with adenoviral vectors is promising in this respect, however, their specific mechanisms of action are not fully understood. Here, we assess…
View article: Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020
Detection of neutralising antibodies to SARS-CoV-2 to determine population exposure in Scottish blood donors between March and May 2020 Open
Background The progression and geographical distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the United Kingdom (UK) and elsewhere is unknown because typically only symptomatic individuals are diagn…
View article: T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses Open
A major issue in identification of protective T cell responses against SARS-CoV-2 lies in distinguishing people infected with SARS-CoV-2 from those with cross-reactive immunity generated by exposure to other coronaviruses. We characterised…
View article: Optimising delivery of therapeutic hepatitis B vaccines to induce resident memory T cells in the liver
Optimising delivery of therapeutic hepatitis B vaccines to induce resident memory T cells in the liver Open
View article: Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020
Detection of neutralising antibodies to SARS coronavirus 2 to determine population exposure in Scottish blood donors between March and May 2020 Open
Background The progression and geographical distribution of SARS coronavirus 2 (SARS-CoV-2) infection in the UK and elsewhere is unknown because typically only symptomatic individuals are diagnosed. We performed a serological study of bloo…
View article: The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV
The Design and Development of a Multi-HBV Antigen Encoded in Chimpanzee Adenoviral and Modified Vaccinia Ankara Viral Vectors; A Novel Therapeutic Vaccine Strategy against HBV Open
Chronic hepatitis B virus (HBV) infection affects 257 million people globally. Current therapies suppress HBV but viral rebound occurs on cessation of therapy; novel therapeutic strategies are urgently required. To develop a therapeutic HB…
View article: Single-cell transcriptome analysis of CD8+ T-cell memory inflation
Single-cell transcriptome analysis of CD8+ T-cell memory inflation Open
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”. These retain functionality, home to peripheral organs and a…
View article: Inflation vs. Exhaustion of Antiviral CD8+ T-Cell Populations in Persistent Infections: Two Sides of the Same Coin?
Inflation vs. Exhaustion of Antiviral CD8+ T-Cell Populations in Persistent Infections: Two Sides of the Same Coin? Open
Persistent virus infection can drive CD8+ T-cell responses which are markedly divergent in terms of frequency, phenotype, function, and distribution. On the one hand viruses such as Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 can dr…
View article: Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines
Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8+ T Cells by Persistent Viruses and Vaccines Open
View article: Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections
Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections Open
For many years, the focus of prophylactic vaccines was to elicit neutralizing antibodies, but it has become increasingly evident that T cell-mediated immunity plays a central role in controlling persistent viral infections such as with hum…
View article: Induction and maintenance of CX3CR1-intermediate peripheral memory CD8 T cells by persistent viruses and novel vaccines
Induction and maintenance of CX3CR1-intermediate peripheral memory CD8 T cells by persistent viruses and novel vaccines Open
View article: Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order
Adenoviral vaccine induction of CD8+ T cell memory inflation: Impact of co-infection and infection order Open
The efficacies of many new T cell vaccines rely on generating large populations of long-lived pathogen-specific effector memory CD8 T cells. However, it is now increasingly recognized that prior infection history impacts on the host immune…
View article: Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors
Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors Open
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricte…
View article: Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection
Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection Open
Previously, we demonstrated that frequencies of CpG and UpA dinucleotides profoundly influence the replication ability of echovirus 7 (Tulloch et al., 2014). Here, we show that that influenza A virus (IAV) with maximised frequencies of the…
View article: Author response: Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection
Author response: Elevation of CpG frequencies in influenza A genome attenuates pathogenicity but enhances host response to infection Open
Full text Figures and data Side by side Abstract Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Previously, we demonstrated that frequencies …