Liana R. Stein
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View article: Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease
Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease Open
View article: ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS
ATH-1105, a small-molecule positive modulator of the neurotrophic HGF system, is neuroprotective, preserves neuromotor function, and extends survival in preclinical models of ALS Open
Introduction Amyotrophic lateral sclerosis (ALS), a progressive and fatal neurodegenerative disorder, primarily affects the motor neurons of the brain and spinal cord. Like other neurodegenerative conditions, ongoing pathological processes…
View article: Klotho controls the brain–immune system interface in the choroid plexus
Klotho controls the brain–immune system interface in the choroid plexus Open
Significance Global depletion of klotho accelerates aging, whereas klotho overexpression counteracts aging-related impairments. Why klotho is expressed at much higher levels in the choroid plexus than in other brain regions is unknown. We …
View article: Dissection method affects electrophysiological properties of hippocampal slices.
Dissection method affects electrophysiological properties of hippocampal slices. Open
The rodent hippocampal slice preparation has long been a critical tool for studying the electrophysiological effects of pharmacological and genetic manipulations. Slices can be prepared with several different slicing methods including the …
View article: Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule‐associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter <scp>VG</scp>lut1
Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule‐associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter <span>VG</span>lut1 Open
Introduction With its preservation of cytoarchitecture and synaptic circuitry, the hippocampal slice preparation has been a critical tool for studying the electrophysiological effects of pharmacological and genetic manipulations. To analyz…
View article: Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture
Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture Open
Although tau has been implicated in diverse neurological diseases, its most pathogenic forms remain to be defined. Our study suggests that reducing the formation or level of pY18-tau can counteract excitotoxicity by diminishing NMDA recept…
View article: Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice Open
View article: Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats
Short-term environmental enrichment enhances synaptic plasticity in hippocampal slices from aged rats Open
View article: Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors
Nampt is required for long-term depression and the function of GluN2B subunit-containing NMDA receptors Open