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View article: Dexmedetomidine Blocks the <scp>ERK</scp> Pathway by Inhibiting <scp>MAP3K8</scp> to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury
Dexmedetomidine Blocks the <span>ERK</span> Pathway by Inhibiting <span>MAP3K8</span> to Achieve a Protective Effect in Lung Ischemia/Reperfusion Injury Open
Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This pape…
View article: Plasma-Derived Small Extracellular Vesicles miR- 182 - 5p Is a Potential Biomarker for Diagnosing Major Depressive Disorder
Plasma-Derived Small Extracellular Vesicles miR- 182 - 5p Is a Potential Biomarker for Diagnosing Major Depressive Disorder Open
Depression, particularly major depressive disorder (MDD), is a debilitating neuropsychiatric condition characterized by high disability rates, primarily driven by chronic stress and genetic predispositions. Emerging evidence highlights the…
View article: Morphological analysis of myocardial bridging leading to myocardial ischemia: myocardial coronary coupling
Morphological analysis of myocardial bridging leading to myocardial ischemia: myocardial coronary coupling Open
Introduction Myocardial bridge (MB) is a segment of an otherwise extramyocardial blood vessel that traverses the myocardium. This congenital condition typically lacks obvious clinical manifestations during adolescence. However, as individu…
View article: [Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer <i>in vitro</i> and <i>in vivo</i>
[Retracted] PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer <i>in vitro</i> and <i>in vivo</i> Open
Following the publication of this article, a concerned reader drew to the Editor's attention that, in the tumor tissue images shown in Fig. 5A and B on p. 1001, there were two pairs of overlapping data panels, such that data which were int…
View article: Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial
Actively implementing an evidence-based feeding guideline for critically ill patients (NEED): a multicenter, cluster-randomized, controlled trial Open
Background Previous cluster-randomized controlled trials evaluating the impact of implementing evidence-based guidelines for nutrition therapy in critical illness do not consistently demonstrate patient benefits. A large-scale, sufficientl…
View article: New application of an old drug proparacaine in treating epilepsy via liposomal hydrogel formulation
New application of an old drug proparacaine in treating epilepsy via liposomal hydrogel formulation Open
Proparacaine (PPC) is a previously discovered topical anesthetic for ophthalmic optometry and surgery by blocking the central Nav1.3. In this study, we found that proparacaine hydrochloride (PPC-HCl) exerted an acute robust antiepileptic e…
View article: A novel method for automatic pharmacological evaluation of sucrose preference change in depression mice
A novel method for automatic pharmacological evaluation of sucrose preference change in depression mice Open
Sucrose preference test (SPT) is a most frequently applied method for measuring anhedonia, a core symptom of depression, in rodents. However, the method of SPT still remains problematic mainly due to the primitive, irregular, and inaccurat…
View article: Breast cancer cell‐derived exosomal miR‐20a‐5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1
Breast cancer cell‐derived exosomal miR‐20a‐5p promotes the proliferation and differentiation of osteoclasts by targeting SRCIN1 Open
Bone metastasis of breast cancer makes patients suffer from pain, fractures, spinal cord compression, and hypercalcemia, and is almost incurable. Although the mechanisms of bone metastasis in breast cancers have been studied intensively, n…
View article: Endoscopic Nasobiliary Drainage Help to Prevent the Postoperative Complications of ERCP for Choledocholith Removal
Endoscopic Nasobiliary Drainage Help to Prevent the Postoperative Complications of ERCP for Choledocholith Removal Open
Aims: In order to investigate the preventive effect of endoscopic nasobiliary drainage (ENBD) on the postoperative complications of ERCP with endoscopic sphincterotomy (EST) for choledocholith. Methods: we collected 180 patients with chole…
View article: PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo
PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo Open
Endothelial PAS domain protein 1 (EPAS1) is a hypoxia-inducible protein that contributes to tumor progression. Hypoxia is involved in tumor aggressiveness and resistance to chemotherapy and ionizing radiation. In this study, we aimed to as…