Liangcong Hu
YOU?
Author Swipe
View article: A core-shell multifunctional microneedle patch accelerates infected diabetic wound healing
A core-shell multifunctional microneedle patch accelerates infected diabetic wound healing Open
Diabetic wounds exhibit impaired angiogenesis, drug-resistant bacterial infections, and oxidative damage to the microenvironment, presenting ongoing clinical challenges. In this research, we designed a core-shell structured multifunctional…
View article: Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases
Immunomodulatory Biomaterials for Bone and Soft Tissue Chronic Inflammation Diseases Open
Chronic inflammatory diseases of bone and soft tissue pose significant clinical challenges due to their complex pathogenesis and the limitations of conventional therapies, which often fail to address immune microenvironment dysregulation. …
View article: The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging
The β-glucan from Lentinus alleviates UVB-induced dermal fibroblasts senescence and skin photoaging Open
Excessive exposure to ultraviolet (UV) radiation results in premature aging of the skin. Lentinan polysaccharide (LNT), has been reported in the literature to exhibit a variety of biological functions, such as anti-inflammatory, antioxidan…
View article: Research progress of gene therapy combined with tissue engineering to promote bone regeneration
Research progress of gene therapy combined with tissue engineering to promote bone regeneration Open
Gene therapy has emerged as a highly promising strategy for the clinical treatment of large segmental bone defects and non-union fractures, which is a common clinical need. Meanwhile, many preclinical data have demonstrated that gene and c…
View article: Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs
Superporous sponge prepared by secondary network compaction with enhanced permeability and mechanical properties for non-compressible hemostasis in pigs Open
View article: Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss Open
The clinical role and underlying mechanisms of valproic acid (VPA) on bone homeostasis remain controversial. Herein, we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density (BMD) in both patients an…
View article: Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization
Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization Open
View article: All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor
All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor Open
In Figure 5, there is a writing error in Figure 5D and 5F.The group names for group 3 and 4 were written reversely.The revised Figure 5 is provided below.
View article: Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment
Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment Open
Increasing data reveals that gelatin that has been methacrylated is involved in a variety of physiologic processes that are important for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel is a highly attractive hydrogels-bas…
View article: Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1
Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1 Open
View article: Traction-bed-assisted reduction and double-plate fixation for treatment of comminuted femoral intertrochanteric fractures with coronal split
Traction-bed-assisted reduction and double-plate fixation for treatment of comminuted femoral intertrochanteric fractures with coronal split Open
Background A coronal comminuted femoral intertrochanteric fracture is a special type of fracture that easily leads to internal fixation failure, and the current internal fixation techniques remain controversial. This study aims to evaluate…
View article: Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist
Injectable Bacteria-Sensitive Hydrogel Promotes Repair of Infected Fractures via Sustained Release of miRNA Antagonist Open
Fracture nonunion can result in considerable physical harm and limitation of quality of life in patients, exerting an extensive economic burden to the society. Nonunion largely results from unresolved inflammation and impaired osteogenesis…
View article: MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2
MiR-1224-5p modulates osteogenesis by coordinating osteoblast/osteoclast differentiation via the Rap1 signaling target ADCY2 Open
MicroRNAs (miRNAs) broadly regulate normal biological functions of bone and the progression of fracture healing and osteoporosis. Recently, it has been reported that miR-1224-5p in fracture plasma is a potential therapy for osteogenesis. T…
View article: Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold
Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold Open
Major traumatic tissue defects are common clinical problems often complicated by infection and local vascular dysfunction, processes which hinder the healing process. Although local application of growth factors or stem cells through vario…
View article: Prognosis and treatment of complications associated with COVID-19: a systematic review and meta-analysis
Prognosis and treatment of complications associated with COVID-19: a systematic review and meta-analysis Open
The Coronavirus Disease 2019 (COVID-19) pandemic has been estimated to have claimed more than 6 million lives, and most deaths have been attributed to complications non-specific to the virus. Therefore, understanding and treating these com…
View article: SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling Open
With the worldwide aging population, the prevalence of osteoporosis is on the rise, particularly the number of postmenopausal women with the condition. However, the various adverse side effects associated with the currently available treat…
View article: Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis Open
Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system, have been widely applied in the treatment of diabetic wounds. Endova…
View article: All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor
All‐in‐One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed‐Release of Exosome and Fibroblast Growth Factor Open
The treatment of diabetic wounds remains a major challenge in clinical practice, with chronic wounds characterized by multiple drug‐resistant bacterial infections, angiopathy, and oxidative damage to the microenvironment. Herein, a novel i…
View article: Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant
Exosomal PD-L1 induces osteogenic differentiation and promotes fracture healing by acting as an immunosuppressant Open
View article: Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway
Polydatin Ameliorates Osteoporosis via Suppression of the Mitogen-Activated Protein Kinase Signaling Pathway Open
Purpose: Polydatin (POL) is a natural active compound found in Polygonum multiflorum with reported anti-oxidant and antiviral effects. With the aging population there has been a stark increase in the prevalence of osteoporosis (OP), render…
View article: Staged Surgical Reconstruction With Skin Expansion of A Marjolin’s Ulcer With Better Recovery: a Case Report
Staged Surgical Reconstruction With Skin Expansion of A Marjolin’s Ulcer With Better Recovery: a Case Report Open
Marjolin’s ulcers (MUs) are one of the most common tumors developed from non-healing wound with chronic inflammation or injury, specially burn scars, over many years. However, the therapy recommendations for MUs are not yet definitive. Her…
View article: Magnetically-Targeted Nanoparticle-Guided M2 Macrophage Polarization For Fracture Healing Promotion
Magnetically-Targeted Nanoparticle-Guided M2 Macrophage Polarization For Fracture Healing Promotion Open
Background: Macrophages are essential for fracture healing, acting mainly through remodeling of the extracellular matrix and promotion of angiogenesis. The role of macrophages in regulating osteogenic differentiation, particularly that of …
View article: Regulatory T cell-exosomal miR-142-3p promotes angiogenesis and osteogenesis via TGFBR1/SMAD2 inhibition to accelerate fracture repair
Regulatory T cell-exosomal miR-142-3p promotes angiogenesis and osteogenesis via TGFBR1/SMAD2 inhibition to accelerate fracture repair Open
Although the immune system is well recognized as a key player in fracture repair, the exact mechanisms, particularly the role of regulatory T-cells (Tregs), have not yet been established. Our increased understanding of the Tregs and exosom…
View article: Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing
Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing Open
Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative stress has been identified as a key factor in impaired diabetic wound healing. Hyperglycemia induces an accumulation of intracellular reactive oxyg…
View article: Management of a Pipkin Type III Femoral Head Fracture Via Ganz Approach with a Cannulated Lag Screw & Herbert Screw
Management of a Pipkin Type III Femoral Head Fracture Via Ganz Approach with a Cannulated Lag Screw & Herbert Screw Open
Objective: To evaluate the medium - to long-term efficacy of a Ganz approach and cannulated lag screw combined with Herbert screw, in the management of a Pipkin type III femoral head fracture.Methods:Retrospective analysis was performed on…
View article: Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis
Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis Open
Background Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising candidates for the treatment of diabetic wound healing. The present study …
View article: miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition
miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition Open
View article: [Retracted] Nomogram for Predicting Deep Venous Thrombosis in Lower Extremity Fractures
[Retracted] Nomogram for Predicting Deep Venous Thrombosis in Lower Extremity Fractures Open
Deep venous thrombosis (DVT) is a common complication in patients with lower extremity fractures, causing delays in recovery short‐term and possible impacts on quality of life long‐term. Early prediction and prevention of thrombosis can ef…
View article: Metformin Alleviated Bone Loss in Ovariectomized Mice Through Inhibition of Autophagy of Osteoclast Precursors Mediated by E2F1
Metformin Alleviated Bone Loss in Ovariectomized Mice Through Inhibition of Autophagy of Osteoclast Precursors Mediated by E2F1 Open
View article: Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature
Exosomes as a Novel Approach to Reverse Osteoporosis: A Review of the Literature Open
Osteoporosis is a chronic disease requiring long-term, sometimes lifelong, management. With the aging population, the prevalence of osteoporosis is increasing, and with it so is the risk of hip fracture and subsequent poor quality of life …