Liangming Liu
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View article: Inhalable targeted CD8 + T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury
Inhalable targeted CD8 + T cell nanoparticles loaded ferroptosis inhibitor ferrostatin-1 alleviate acute lung injury Open
Acute lung injury (ALI) is a common clinical complication of sepsis and ferroptosis plays an important role in ALI. The aim of this study was to evaluate the effects of CD8 antibodies modified PD-1 engineered CD8+ T lymphocytes …
View article: Correction: Effects of Malate Ringer’s solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR
Correction: Effects of Malate Ringer’s solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR Open
View article: The role of four ERS-related key genes in sepsis induced organ dysfunction and the forewarning model construction
The role of four ERS-related key genes in sepsis induced organ dysfunction and the forewarning model construction Open
View article: Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis
Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis Open
Accurate early diagnosis and prognosis of sepsis remain major clinical challenges. This study explores specific plasma cell‐free mitochondrial DNA (cfmtDNA) breakage patterns as potential biomarkers for sepsis. Plasma samples from ten non‐…
View article: Corrigendum: Mitochondrial-derived vesicles protect cardiomyocytes against hypoxic damage
Corrigendum: Mitochondrial-derived vesicles protect cardiomyocytes against hypoxic damage Open
[This corrects the article DOI: 10.3389/fcell.2020.00214.].
View article: Correction: l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway
Correction: l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway Open
View article: Correction: Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways
Correction: Drp1 regulates mitochondrial dysfunction and dysregulated metabolism in ischemic injury via Clec16a-, BAX-, and GSH- pathways Open
View article: Protective Effects of Mdivi‐1 on Cognition Disturbance Following Sepsis in Mice via Alleviating Microglia Activation and Polarization
Protective Effects of Mdivi‐1 on Cognition Disturbance Following Sepsis in Mice via Alleviating Microglia Activation and Polarization Open
Background Neuroinflammation is one of the essential pathogeneses of cognitive damage suffering from sepsis‐associated encephalopathy (SAE). Lots of evidences showed the microglia presented mitochondrial fragmentation during SAE. This stud…
View article: Corrigendum: Protective effects of inhibition of mitochondrial fission on organ function after sepsis
Corrigendum: Protective effects of inhibition of mitochondrial fission on organ function after sepsis Open
[This corrects the article DOI: 10.3389/fphar.2021.712489.].
View article: THE MITOCHONDRIAL DIVISION INHIBITOR MDIVI-1 PROTECTED ORGAN FUNCTION AND EXTENDED THE TREATMENT WINDOW IN RATS WITH UNCONTROLLED HEMORRHAGIC SHOCK
THE MITOCHONDRIAL DIVISION INHIBITOR MDIVI-1 PROTECTED ORGAN FUNCTION AND EXTENDED THE TREATMENT WINDOW IN RATS WITH UNCONTROLLED HEMORRHAGIC SHOCK Open
Aim: This study aimed to elucidate whether the application of the mitochondrial division inhibitor Mdivi-1 can protect organ function and prolong the treatment window for traumatic hemorrhagic shock. Methods: Before definitive hemostasis t…
View article: Correction: Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats
Correction: Mesenchymal stem cell-derived microvesicles improve intestinal barrier function by restoring mitochondrial dynamic balance in sepsis rats Open
View article: Interleukin-1β-stimulated macrophage-derived exosomes improve myocardial injury in sepsis via regulation of mitochondrial homeostasis: experimental research
Interleukin-1β-stimulated macrophage-derived exosomes improve myocardial injury in sepsis via regulation of mitochondrial homeostasis: experimental research Open
Background: The purpose of this study was to investigate the effects of interleukin-1β (IL-1β) stimulation on the protection of macrophage-derived exosomes miR-146a (M-IL-exo-146a) on sepsis-induced myocardial injury (SMI) in vitro and in …
View article: Corrigendum: Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis
Corrigendum: Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis Open
[This corrects the article DOI: 10.3389/fimmu.2023.1181697.].
View article: 4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara
4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara Open
Introduction Cardiac dysfunction after sepsis the most common and severe sepsis-related organ failure. The severity of cardiac damage in sepsis patients was positively associated to mortality. It is important to look for drugs targeting se…
View article: Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance
Notoginsenoside R1 improves intestinal microvascular functioning in sepsis by targeting Drp1-mediated mitochondrial quality imbalance Open
Drp1-mediated mitochondrial quality imbalance is a potential therapeutic target for sepsis. Small molecule natural drugs like NGR1 targeting Drp1 may offer new directions for organ protection following sepsis. Future research should focus …
View article: Exosomes miRNA-499a-5p targeted CD38 to alleviate anthraquinone induced cardiotoxicity: experimental research
Exosomes miRNA-499a-5p targeted CD38 to alleviate anthraquinone induced cardiotoxicity: experimental research Open
Background: The purpose of this study was to investigate the effects of cardiac homing peptide (CHP) engineered bone marrow mesenchymal stem cells (BMMSc) derived exosomes (B-exo) loaded miRNA-499a-5p on doxorubicin (DOX) induced cardiotox…
View article: Metabolomics and machine learning approaches for diagnostic and prognostic biomarkers screening in sepsis
Metabolomics and machine learning approaches for diagnostic and prognostic biomarkers screening in sepsis Open
View article: Activated Drp1 Initiates the Formation of Endoplasmic Reticulum‐Mitochondrial Contacts via Shrm4‐Mediated Actin Bundling
Activated Drp1 Initiates the Formation of Endoplasmic Reticulum‐Mitochondrial Contacts via Shrm4‐Mediated Actin Bundling Open
Excessive mitochondrial fission following ischemia and hypoxia relies on the formation of contacts between the endoplasmic reticulum and mitochondria (ER‐Mito); however, the specific mechanisms behind this process remain unclear. Confocal …
View article: Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies
Neutrophil membrane-engineered Panax ginseng root-derived exosomes loaded miRNA 182-5p targets NOX4/Drp-1/NLRP3 signal pathway to alleviate acute lung injury in sepsis: experimental studies Open
Background: The purpose of this study was to prepare neutrophil membrane-engineered Panax ginseng root-derived exosomes (N-exo) and investigate the effects of N-exo microRNA (miRNA) 182-5p (N-exo-miRNA 182-5p) on acute lung injury (ALI) in…
View article: l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway
l-Arginine, as an essential amino acid, is a potential substitute for treating COPD via regulation of ROS/NLRP3/NF-κB signaling pathway Open
Backgrounds Chronic obstructive pulmonary disease (COPD) is a frequent and common disease in clinical respiratory medicine and its mechanism is unclear. The purpose of this study was to find the new biomarkers of COPD and elucidate its rol…
View article: Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis
Integrative single-cell RNA sequencing and metabolomics decipher the imbalanced lipid-metabolism in maladaptive immune responses during sepsis Open
Background To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Methods The lipid metabolism-related hub genes were screened using machine learning algorithms, and the…
View article: Effects of Mdivi‐1 on Extending the Golden Treatment Time following Hemorrhagic Shock in Hot Environment in Rats
Effects of Mdivi‐1 on Extending the Golden Treatment Time following Hemorrhagic Shock in Hot Environment in Rats Open
It is found that a hot environment aggravates hemorrhagic shock‐induced internal environment and organ dysfunction. Meanwhile mitochondria show over‐fission. Whether inhibition of mitochondrial fission benefits from the early treatment of …
View article: Protective Effect of Modified Hemoglobin on Rabbits and Goats in High‐Altitude Sickness
Protective Effect of Modified Hemoglobin on Rabbits and Goats in High‐Altitude Sickness Open
The prevalence and severity of high‐altitude sickness increases with increasing altitude. Prevention of hypoxia caused by high‐altitude sickness is an urgent problem. As a novel oxygen‐carrying fluid, modified hemoglobin can carry oxygen i…
View article: Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning
Identification of featured necroptosis-related genes and imbalanced immune infiltration in sepsis via machine learning Open
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (D…
View article: Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles
Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles Open
View article: Genistein, a Soybean Isoflavone, Promotes Wound Healing by Enhancing Endothelial Progenitor Cell Mobilization in Rats with Hemorrhagic Shock
Genistein, a Soybean Isoflavone, Promotes Wound Healing by Enhancing Endothelial Progenitor Cell Mobilization in Rats with Hemorrhagic Shock Open
Severe trauma and hemorrhaging are often accompanied by delayed cutaneous wound healing. Soybean isoflavone is a natural phytoestrogen that has attracted great attention due to its protective effects against various injuries. Endothelial p…
View article: VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis
VDAC2 malonylation participates in sepsis-induced myocardial dysfunction via mitochondrial-related ferroptosis Open
Sepsis-induced myocardial dysfunction (SIMD) is a prevalent and severe form of organ dysfunction with elusive underlying mechanisms and limited treatment options. In this study, the cecal ligation and puncture and lipopolysaccharide (LPS) …
View article: Effects of Malate Ringer's solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR
Effects of Malate Ringer's solution on myocardial injury in sepsis and enforcement effects of TPP@PAMAM-MR Open
Background Myocardial dysfunction played a vital role in organ damage after sepsis. Fluid resuscitation was the essential treatment in which Lactate Ringer's solution (LR) was commonly used. Since LR easily led to hyperlactatemia, its resu…
View article: Protective effect of dexmedetomidine on intestinal barrier function in septic rats
Protective effect of dexmedetomidine on intestinal barrier function in septic rats Open
Objective To investigate the protective effect of dexmedetomidine (DEX) on intestinal barrier in septic rats. Methods Rat model of sepsis was induced by cecal ligation and puncture (CLP). SD rats were randomly divided into 4 groups: sham o…
View article: Advances and thinking for early treatment of war wound and traumatic shock
Advances and thinking for early treatment of war wound and traumatic shock Open
Traumatic shock is a main cause for early death of war wound and trauma. As for the early treatment of war wound and traumatic shock, many new concepts and techniques have been raised in recent years, such as limited fluid resuscitation, p…