Explanipedia

Does Metabolic Status Associate With <span>IVF</span> Outcomes in Women Within Similar Body Mass Index Category: Evidence From a Large Cohort Study Open

Lin Ding, Xiaojing Lin, Peipei Pan, Yan Li, Wei Chen , et al. · 2025

Objectives Whether diverse metabolic statuses within a similar body mass index (BMI) category associate with different in vitro fertilization (IVF) outcomes. Design A retrospective cohort study. Setting Wenzhou, Zhengjiang Province, China.…

Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and the HIF‐1 Pathway in Polycystic Ovary Syndrome Open

Guiquan Wang, Weian Mao, Yurong Zhang, Haiyan Yang, Zhu Ming , et al. · 2025

Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here…

Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study Open

Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan , et al. · 2025

Background Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is highly associated with adverse perinatal outcomes and long‐term health problems for the mother and offspring. However, there are res…

Spatiotemporally Resolved Transcriptomics of Developing Placenta Reveals Mechanisms of Embryonic Lethality Open

Yuting Fu, Xiaoqi Zeng, Yifang Liu, Shikai Jia, Yujia Jiang , et al. · 2025

Transcriptomic profiling of day 3 human embryos of poor quality reveals molecular links to divergent developmental trajectories Open

Li Yan, Wencheng Zhu, Yuchen Qian, Haiyan Yang, Yonggen Wu , et al. · 2024

Poor-quality (PQ) embryos are commonly formed in assisted reproduction and often discarded, but emerging evidence suggests that some can develop into healthy children. Here, we performed single-embryo transcriptome profiling of day 3 human…

Independent and joint effects of β-cell dysfunction and insulin resistance on reproductive outcomes of IVF cycles in infertile PCOS patients Open

Chang Liu, Lin Ding, Yan Li, Pei‐Yu Wang, Jia Lin , et al. · 2024

Objective To investigate the independent and joint effects of insulin resistance and β-cell dysfunction on reproductive outcomes in women with polycystic ovary syndrome (PCOS) undergoing in-vitro fertilization (IVF). Design A single-centre…

PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome Open

Liangshan Mu, Zhenhong Ye, Junhao Hu, Yurong Zhang, Kai Chen , et al. · 2023

This study was supported by the National Key Research and Development Program of China (2021YFC2700402, 2019YFA0802503), the National Natural Science Foundation of China (81871139, 82001503, 92057107), the CAMS Innovation Fund for Medical …

Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome Open

Siyu Wang, Liangshan Mu, Chunmei Zhang, Xiaoyu Long, Yurong Zhang , et al. · 2022

Background Women with polycystic ovary syndrome (PCOS) suffer from dysfunctional metabolism and studies have reported increased levels of tryptophan in patients with PCOS. However, the changes of downstream metabolites in tryptophan catabo…

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction Open

Kai-Lun Hu, Zimiao Chen, Xiaoxue Li, Enci Cai, Haiyan Yang , et al. · 2022

Background Kisspeptin is the leading upstream regulator of pulsatile and surge Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as the key governor of the hypothalamic-pituitary-ovary axis. Main text Exogeno…

Elevated Levels of Follicular Fatty Acids Induce Ovarian Inflammation via ERK1/2 and Inflammasome Activation in PCOS Open

Yu-Chen Lai, Zhenhong Ye, Liangshan Mu, Yurong Zhang, Xiaoyu Long , et al. · 2022

Context Polycystic ovary syndrome (PCOS) is accompanied by chronic inflammation and metabolic disorders. Whether metabolic abnormalities affect inflammation in PCOS or not, the underlying mechanism remains to be clarified. Objective We aim…

Association Between Neck Circumference And Metabolic Syndrome In Women With Polycystic Ovary Syndrome Open

Chang Liu, Liangshan Mu, Lin Ding, Haiyan Yang, Zimiao Chen · 2021

Objective: To explore the correlation of neck circumference (NC) with metabolic syndrome (MetS) and metabolic risk factors, and assess the predictive value of NC for MetS in women with polycystic ovary syndrome (PCOS). Methods: This is a c…

Identification of differentially expressed genes and signalling pathways related to ovarian endometriosis based on integrated bioinformatic analysis Open

Kainan Lin, Zhenyan Pan, Renke He, Hanchu Wang, Kai Zhou , et al. · 2021

Purpose Endometriosis is a common gynaecological disease; however, the specific mechanism and the key molecules involved in endometriosis have not been elucidated. This study aimed to identify key genes associated with poor prognosis and f…

Identification of Differentially Expressed Genes and Signalling Pathways Related to Ovarian Endometriosis Based on Integrated Bioinformatic Analysis Open

Kainan Lin, Zhenyan Pan, Renke He, Hanchu Wang, Kai Zhou , et al. · 2021

Purpose: Endometriosis is a common gynaecological disease; however, the specific mechanism and the key molecules involved in endometriosis have not been elucidated. This study aimed to identify key genes associated with poor prognosis and …

Non-coding RNAs in polycystic ovary syndrome: a systematic review and meta-analysis Open

Liangshan Mu, Xiaoting Sun, Mixue Tu, Dan Zhang · 2021

Background Genetic, environmental and epigenetical factors may play important roles in the pathogenesis of polycystic ovary syndrome (PCOS), however the etiology of PCOS remains unclear. Studies indicated that non-coding RNAs (ncRNAs) were…

Specific Immune Phenotypes Protect Individuals Against COVID-19 Susceptibility and Severity: A Mendelian Randomization Study Open

Xiu‐Feng Huang, Wenhai Deng, Liangshan Mu, Congying Xie, Jie Liu , et al. · 2021

Identification of Differentially Expressed Genes and Signaling Pathways Related to Ovarian Endometriosis by Integrated Bioinformatics Analysis Open

Kainan Lin, Zhenyan Pan, Renke He, Hanchu Wang, Kai Zhou , et al. · 2020

Purpose: Endometriosis was a common gynecological disease, however, the specific mechanism and the key molecules of endometriosis remained uncertain. This study aimed to single out key genes associated with poor prognosis, and further unco…

Association between Serum Prolactin and Metabolic Disorders: a Systematic Review Open

Zaibo Yang, Junsen She, Cong-Cong Zhou, Liangshan Mu · 2020

Background Serum prolactin levels are associated with metabolic disorders. However, the conclusions were inconsistent among published studies. Methods PubMed, EMBASE, and the Cochrane Library were used to search for studies investigating t…

Publisher Correction: Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome Open

Xinyu Qi, Chuyu Yun, Lulu Sun, Jialin Xia, Qing Wu , et al. · 2019

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome Open

Xinyu Qi, Chuyu Yun, Lulu Sun, Jialin Xia, Qing Wu , et al. · 2019

Subclinical Hypothyroidism in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Open

Xiaohong Ding, Lili Yang, Jian Wang, Rong Tang, Qianqian Chen , et al. · 2018

Background: The association between subclinical hypothyroidism (SCH) and polycystic ovary syndrome (PCOS) has been reported in several studies, but it is not well-recognized. The aim of this study was to evaluate the prevalence of S…

Role of Ketotifen on metabolic profiles, inflammation and oxidative stress in diabetic rats Open

Zimiao Chen, Hongwei Sun, Jian Wang, Lian-song Ni, Xuejiang Gu , et al. · 2017

We aim to explore effects of Ketotifen on metabolic profiles, inflammation and oxidative stress. Sprague Dawley (SD) male rats were randomly divided into normal control group (NC) and experimental groups, and experimental group rats were f…

ABO blood type is associated with ovarian reserve in Chinese women with subfertility Open

Liangshan Mu, Wumin Jin, Haiyan Yang, Xia Chen, Jiexue Pan , et al. · 2016

Ovarian reserve reflects both the quantity and quality of oocytes available for procreation, and is affected by many known and unknown factors. ABO blood type is related to a number of infertility processes, but it is unclear whether and h…

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