Liangye Ji
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View article: Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP
Alpha-lipoic acid alleviates cognitive deficits in transgenic APP23/PS45 mice through a mitophagy-mediated increase in ADAM10 α-secretase cleavage of APP Open
View article: <scp>ICA1</scp> affects <scp>APP</scp> processing through the <scp>PICK1‐PKCα</scp> signaling pathway
<span>ICA1</span> affects <span>APP</span> processing through the <span>PICK1‐PKCα</span> signaling pathway Open
Aims Islet cell autoantigen 1 (ICA1) is involved in autoimmune diseases and may affect synaptic plasticity as a neurotransmitter. Databases related to Alzheimer's disease (AD) have shown decreased ICA1 expression in patients with AD. Howev…
View article: SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation
SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation Open
SIL1, an endoplasmic reticulum (ER)-resident protein, is reported to play a protective role in Alzheimer's disease (AD). However, the effect of SIL1 on amyloid precursor protein (APP) processing remains unclear. In this study, the role of …
View article: Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice
Astrocyte-Ablation of Mtnr1b Increases Anxiety-Like Behavior in Adult Male Mice Open
Background: Astrocytes are essential for synaptic transmission, and their dysfunction can result in neuropsychiatric disorders such as anxiety and depression. Many studies have shown that global knockout of Melatonin receptor 2 (Mtnr1b) is…