Liankun Gu
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View article: STAMBP Accelerates Progression and Tamoxifen Resistance of Breast Cancer Through Deubiquitinating ERα
STAMBP Accelerates Progression and Tamoxifen Resistance of Breast Cancer Through Deubiquitinating ERα Open
Breast cancer (BRCA) remains a global health burden, with endocrine-resistant ER-positive BRCA posing therapeutic challenges. This study investigates STAMBP’s role in breast cancer progression and evaluates its potential as a therapeutic t…
View article: NRF1 Predominantly Causes EZH2 Overexpression in Cancer Cells
NRF1 Predominantly Causes EZH2 Overexpression in Cancer Cells Open
EZH2 is an oncogene and therapeutic target. Only a small proportion of cancer patients benefit from treatment with EZH2 inhibitors (EZH2is). The mechanisms underlying EZH2 overexpression and EZH2i resistance are not clear. Here, we reporte…
View article: Lessons from a gene knockout mouse model: no phenotypes induced by deletion of the TPR4 domain of Ttc22
Lessons from a gene knockout mouse model: no phenotypes induced by deletion of the TPR4 domain of Ttc22 Open
The TTC22 gene encodes a protein containing seven tetratricopeptide repeats (TPRs), which mediate protein‒protein interactions as chaperones. We previously reported that the level of TTC22 transcript variant 1 ( TTC22v1 ) was downregulated…
View article: TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation
TTC7B triggers the PI4KA-AKT1-RXRA-FTO axis and inhibits colon cancer cell proliferation by increasing RNA methylation Open
TTC7B is the PI4KA-binding protein. The upstream regulatory network associated with the expression of genes involved in RNA N6-adenine (m6A) methylation is not clear. Bioinformatics analysis revealed that the expression levels of TTC7B, PI…
View article: The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy
The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone-mediated autophagy Open
There are three distinct forms of autophagy, namely, macroautophagy, microautophagy, and HSPA8 chaperone-mediated autophagy (CMA). While macroautophagy is widely recognized as a regulator of chromosomal instability (CIN) through various pa…
View article: Somatic CDKN2A copy number variations are associated with the prognosis of esophageal squamous cell dysplasia
Somatic CDKN2A copy number variations are associated with the prognosis of esophageal squamous cell dysplasia Open
Background: Somatic copy number variations (SCNVs) in the CDKN2A gene are among the most frequent events in the dysplasia-carcinoma sequence of esophageal squamous cell carcinoma. However, whether CDKN2A SCNVs are useful biomarkers for the…
View article: Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts
Driving effect of P16 methylation on telomerase reverse transcriptase-mediated immortalization and transformation of normal human fibroblasts Open
Background: P16 inactivation is frequently accompanied by telomerase reverse transcriptase ( TERT ) amplification in human cancer genomes. P16 inactivation by DNA methylation often occurs automatically during immortalization of normal cell…
View article: LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner
LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner Open
The MIR663AHG gene encodes both miR663AHG and miR663a . While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AHG has not been previously …
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S2. Volcano-plots showing female/male ratio of the average CCCGGG-methylation signal of each probe for sex chromosomes X (A), Y (B), and autosomes (C) in the SM samples; Distribution of the proportion of hypermethylate…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S1. Workflow for characterization of GC metastasis biomarkers.
View article: Supplementary Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
Supplementary Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study Open
Supplementary Data from Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Materials and Methods. Primer sequences, PCR condition, bisulfite-sequencing, tissue microarray, immunohistochemical staining.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S4. Methylation levels of GFRA1, SRF, and ZNF382 by DHPLC are confirmed by MethyLight and inversely correlated with their transcription levels. (A) Correlation between DNA methylation levels measured by DHPLC and Methy…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S2. Volcano-plots showing female/male ratio of the average CCCGGG-methylation signal of each probe for sex chromosomes X (A), Y (B), and autosomes (C) in the SM samples; Distribution of the proportion of hypermethylate…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S1. Clinicopathological information of 8 patients with GCs used in methylome analysis.
View article: Supplementary Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
Supplementary Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study Open
Supplementary Data from Methylation of p16 CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S3. DHPLC chromatograms and bisulfite-sequencing of 12 GC-related gene methylation changes.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S5. IHC images of GCs and SMs in the GFRA1, SRF, and ZNF382 immunostaining.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S2. List of CpG islands of the 73 candidate genes selected for methylation analysis by DHPLC.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S3. DHPLC chromatograms and bisulfite-sequencing of 12 GC-related gene methylation changes.
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S4. Methylation levels of GFRA1, SRF, and ZNF382 by DHPLC are confirmed by MethyLight and inversely correlated with their transcription levels. (A) Correlation between DNA methylation levels measured by DHPLC and Methy…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Table S1. Clinicopathological information of 8 patients with GCs used in methylome analysis.
View article: Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Purpose: Metastasis is the leading cause of death for gastric carcinoma. An epigenetic biomarker panel for predicting gastric carcinoma metastasis could have significant clinical impact on the care of patients with gastric carcinoma. The m…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S1. Workflow for characterization of GC metastasis biomarkers.
View article: Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study Open
Purpose: Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia. To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospecti…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Materials and Methods. Primer sequences, PCR condition, bisulfite-sequencing, tissue microarray, immunohistochemical staining.
View article: Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study
Data from Methylation of <i>p16</i> CpG Island Associated with Malignant Progression of Oral Epithelial Dysplasia: A Prospective Cohort Study Open
Purpose: Inactivation of p16 gene by CpG methylation is a frequent event in oral epithelial dysplasia. To investigate the predictive value of p16 methylation on malignant potential in oral epithelial dysplasia, we carried out the prospecti…
View article: Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis
Data Supplement from Large-Scale Characterization of DNA Methylation Changes in Human Gastric Carcinomas with and without Metastasis Open
Supplementary Figure S5. IHC images of GCs and SMs in the GFRA1, SRF, and ZNF382 immunostaining.