Lianlian Zhao
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View article: Exposure to diverse airborne bacterial communities following Klebsiella pneumoniae infection elicits distinct host response mechanisms in mice
Exposure to diverse airborne bacterial communities following Klebsiella pneumoniae infection elicits distinct host response mechanisms in mice Open
Our findings demonstrate that varied airborne bacterial communities exposure exert differential effects on convalescent pneumonia in mice. This influence may be mediated, at least in part, by modulating disease progression through the lung…
View article: Five-month real-ambient PM2.5 exposure impairs learning in Brown Norway rats: Insights from multi omics-based analysis
Five-month real-ambient PM2.5 exposure impairs learning in Brown Norway rats: Insights from multi omics-based analysis Open
PM2.5, recognized as a potential pathogenic factor for nervous system diseases, remains an area with many unknowns, particularly regarding its effects on human health. After five-month real-ambient PM2.5 exposure, we …
View article: Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system
Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system Open
A study was conducted to evaluate the three-dimensional clinostat simulated microgravity effect on mouse models, focusing on the central nervous system. Eighteen mice were divided into three groups: control, survival box, and clinostat + s…
View article: Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens
Effect of PM2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens Open
View article: Impact of variations in airborne microbiota on pneumonia infection: An exploratory study
Impact of variations in airborne microbiota on pneumonia infection: An exploratory study Open
This study demonstrated the significant and systemic impact of air microbiota structure differences on health. Future research should explore the underlying mechanisms to enhance our understanding of the air-environment-health relationship…
View article: Effect of PM 2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens
Effect of PM 2.5 exposure on susceptibility to allergic asthma in elderly rats treated with allergens Open
Fine particulate matter 2.5 (PM2.5) is an environmental pollutant in the atmosphere that is closely associated with asthma. Elderly patients have a high incidence of asthma with a long course of illness. Our previous studies rev…
View article: Preparation for mice spaceflight: Indications for training C57BL/6J mice to adapt to microgravity effect with three-dimensional clinostat on the ground
Preparation for mice spaceflight: Indications for training C57BL/6J mice to adapt to microgravity effect with three-dimensional clinostat on the ground Open
Like astronauts, animals need to undergo training and screening before entering space. At present, pre-launch training for mice mainly focuses on adaptation to habitat system. Training for the weightless environment of space in mice has no…
View article: PM2.5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis
PM2.5 exposure promotes asthma in aged Brown-Norway rats: Implication of multiomics analysis Open
Children are disproportionately represented among those who suffer asthma, which is a kind of chronic airway inflammation. Asthma symptoms might worsen when exposed to the air pollutant particulate matter 2.5 (PM2.5). However, i…
View article: Radiomics Signatures of Carotid Plaque on Computed Tomography Angiography
Radiomics Signatures of Carotid Plaque on Computed Tomography Angiography Open
View article: The temporal characteristics of the disruption of gut microbiota, serum metabolome, and cytokines by silica exposure in wistar rats
The temporal characteristics of the disruption of gut microbiota, serum metabolome, and cytokines by silica exposure in wistar rats Open
Silicosis is one of the most frequent, rapidly developing, and lethal types of pneumoconiosis. However, our understanding of the underlying mechanisms of its pathogenesis and progress remains unclear. We investigated the fundamental proces…