Lianne Q. Chau
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View article: Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma
Ras-Responsive Element Binding Protein 1 regulates survival of Group 3 medulloblastoma Open
Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and Group 3 (G3, MYC-driven) MB has the worst prognosis. Despite advances in molecular classification, oncogenic drivers of G3 MB remain poorly defined. To identify s…
View article: TRLS-13. MULTI-OMICS AND FUNCTIONAL PRECISION MEDICINE FOR NEWLY DIAGNOSED AND RECURRENT PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS
TRLS-13. MULTI-OMICS AND FUNCTIONAL PRECISION MEDICINE FOR NEWLY DIAGNOSED AND RECURRENT PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS Open
BACKGROUND Comprehensive molecular characterization of pediatric brain tumors has led to a more refined diagnosis. However, the feasibility of performing multi-omic and functional precision medicine approaches using ex-vivo drug screening …
View article: Data from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Data from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. Improved outcomes for patients with CPC depend on a deeper understanding of the mec…
View article: Supplementary Fig 7 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 7 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S7 shows effects of CDK4/6 inhibitors on viability of mouse CPC cells and drug synergy between Triptolide and Dinaciclib.
View article: Data from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Data from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Choroid plexus carcinoma (CPC) is a rare brain tumor that occurs most commonly in very young children and has a dismal prognosis despite intensive therapy. Improved outcomes for patients with CPC depend on a deeper understanding of the mec…
View article: Supplementary Fig 4 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 4 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S4 shows the expression of MYC and Ki67 by immunohistochemistry in human choroid plexus carcinoma patient specimens.
View article: Supplementary Figures and Legends from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Supplementary Figures and Legends from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Supplementary Figures 1-5
View article: Supplementary Fig 1 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 1 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S1 shows other models of choroid plexus tumors generated from different Cre lines and their corresponding Kaplan-Meier survival curve.
View article: Supplementary Fig 4 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 4 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S4 shows the expression of MYC and Ki67 by immunohistochemistry in human choroid plexus carcinoma patient specimens.
View article: Supplementary Fig 7 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 7 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S7 shows effects of CDK4/6 inhibitors on viability of mouse CPC cells and drug synergy between Triptolide and Dinaciclib.
View article: Supplementary Fig 3 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 3 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S3 shows lineage tracing of Blbp+ progenitors in the choroid plexus of the lateral ventricle and 4th ventricle of the mouse brain.
View article: Supplementary Figure Legends from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Figure Legends from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Supplementary Figure Legends
View article: Supplementary Fig 6 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 6 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S6 shows Monte Carlo simulation to test the probability of significantly underexpressed human and murine genes overlapping by chance.
View article: Supplementary Fig 2 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 2 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S2 shows H&E staining on Atoh1-Cre CPC.
View article: Data from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Data from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterog…
View article: Supplementary Figure Legends from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Figure Legends from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Supplementary Figure Legends
View article: Supplementary Tables from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Supplementary Tables from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Supplementary Tables 1-11
View article: Supplementary Tables from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Supplementary Tables from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Supplementary Tables 1-11
View article: Supplementary Figures and Legends from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Supplementary Figures and Legends from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Supplementary Figures 1-5
View article: Supplementary Fig 1 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 1 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S1 shows other models of choroid plexus tumors generated from different Cre lines and their corresponding Kaplan-Meier survival curve.
View article: Data from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Data from Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterog…
View article: Supplementary Fig 6 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 6 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S6 shows Monte Carlo simulation to test the probability of significantly underexpressed human and murine genes overlapping by chance.
View article: Supplementary Fig 2 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 2 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S2 shows H&E staining on Atoh1-Cre CPC.
View article: Supplementary Fig 5 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 5 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S5 shows reduced expression of genes on mouse chomosomes 8, 12 and 19 due to decreased DNA copy number.
View article: Supplementary Fig 5 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 5 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S5 shows reduced expression of genes on mouse chomosomes 8, 12 and 19 due to decreased DNA copy number.
View article: Supplementary Fig 3 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma
Supplementary Fig 3 from Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma Open
Figure S3 shows lineage tracing of Blbp+ progenitors in the choroid plexus of the lateral ventricle and 4th ventricle of the mouse brain.
View article: Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma
Retraction Note: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma Open
View article: Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor
Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor Open
View article: Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma
Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma Open
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterog…
View article: NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma
NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma Open
Tumor cells are characterized by unlimited proliferation and perturbed differentiation. Using single-cell RNA sequencing, we demonstrate that tumor cells in medulloblastoma (MB) retain their capacity to differentiate in a similar way as th…