Liantao Li
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View article: TKT drives renal cell carcinoma progression through metabolic reprogramming and synergistic interaction with PKM2
TKT drives renal cell carcinoma progression through metabolic reprogramming and synergistic interaction with PKM2 Open
Renal cell carcinoma (RCC) undergoes profound metabolic reprogramming to fuel its aggressive progression and metastatic dissemination. While transketolase (TKT), a central metabolic enzyme, has been shown to exert dichotomous roles as eith…
View article: Commentary: integrating inflammation and immunity—a new frontier in NSCLC neoadjuvant strategy
Commentary: integrating inflammation and immunity—a new frontier in NSCLC neoadjuvant strategy Open
View article: O-269 Optimized PGT-M strategy using gametes or arrested embryos from parents with no proband: addressing challenging cases
O-269 Optimized PGT-M strategy using gametes or arrested embryos from parents with no proband: addressing challenging cases Open
Study question How to optimize haplotype construction in complex PGT-M scenarios without proband samples and with anticipated difficulties in identifying an embryo carrier as proband (EAP)? Summary answer Leveraging gametes and arrested em…
View article: Relationships between blood cadmium concentration and risk of nine cancers: evidence from the NHANES 1999–2018 and Mendelian randomization analyses
Relationships between blood cadmium concentration and risk of nine cancers: evidence from the NHANES 1999–2018 and Mendelian randomization analyses Open
Elevated BCC was associated with an increased risk of bladder and lung cancers while demonstrating an inverse relationship with kidney and prostate cancers. MR analysis revealed that cadmium exposure may act as a protective factor against …
View article: 83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study
83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study Open
View article: DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell
DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell Open
Pyroptosis is one of the ways to cause proximal tubular epithelial cell death in diabetic nephropathy (DN), but the exact mechanism remains unclear. Absent in melanoma 2 (AIM2), a sensor for double-stranded DNA, creates an inflammasome tha…
View article: Nonlinear association of alkaline phosphatase-to-albumin ratio with all-cause and cancer mortality: Evidence from NHANES 2005 to 2016
Nonlinear association of alkaline phosphatase-to-albumin ratio with all-cause and cancer mortality: Evidence from NHANES 2005 to 2016 Open
The relationship between the alkaline phosphatase-to-albumin ratio (APAR) and mortality remains unclear. This research looked into the association between APAR levels and cause-specific mortality in US adults. A cohort of 7561 participants…
View article: Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment
Harnessing nanomedicine to overcome the immunosuppressive tumor microenvironment Open
View article: Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo
Nanoparticle Drug Delivery Can Reduce the Hepatotoxicity of Therapeutic Cargo Open
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have n…
View article: Correction: Klotho reduces the risk of osteoporosis in postmenopausal women: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES)
Correction: Klotho reduces the risk of osteoporosis in postmenopausal women: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) Open
View article: Non-linear Association of Alkaline Phosphatase-to-Albumin Ratio with All-Cause and Cancer Mortality: Evidence from NHANES 2005-2016
Non-linear Association of Alkaline Phosphatase-to-Albumin Ratio with All-Cause and Cancer Mortality: Evidence from NHANES 2005-2016 Open
Background The relationship between the alkaline phosphatase-to-albumin ratio (APAR) and mortality remains unclear. This research looked into the association between APAR levels and cause-specific mortality in US adults. Methods A cohort o…
View article: Survival benefit of postoperative radioiodine therapy among patients with intermediate-risk differentiated thyroid carcinoma
Survival benefit of postoperative radioiodine therapy among patients with intermediate-risk differentiated thyroid carcinoma Open
Background The 2015 American Thyroid Association (ATA) guidelines proposed the ATA Risk Stratification System and American Joint Committee on Cancer Tumor-Node-Metastasis (AJCC/TNM) Staging System for postoperative radioiodine decision-mak…
View article: Quantum Machine Learning-Based Prediction of 10-Year Survival in Differentiated Thyroid Cancer
Quantum Machine Learning-Based Prediction of 10-Year Survival in Differentiated Thyroid Cancer Open
View article: The role of adjuvant radiotherapy after surgery in early-stage tongue carcinoma. A systematic review and meta-analysis
The role of adjuvant radiotherapy after surgery in early-stage tongue carcinoma. A systematic review and meta-analysis Open
Study designs to be included Retrospective studies or randomized controlled trials. Eligibility criteria (1) Tongue cancer confirmed by pathological diagnosis;(2) The stage of patients was T1-2N0M0; (3) Providing survival data, including h…
View article: IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects Open
CD1d-restricted invariant NKT (iNKT) cells play a critical role in tumor immunity. However, the scarcity and limited persistence restricts their development and clinical application. Here, we demonstrated that iNKT cells could be efficient…
View article: [Hsa-miR-148a-3p promotes malignant behavior of breast cancer cells by downregulating DUSP1].
[Hsa-miR-148a-3p promotes malignant behavior of breast cancer cells by downregulating DUSP1]. Open
Hsa-miR-148a-3p promotes malignant behavior of breast cancer cells by inhibiting the expression of DUSP1.
View article: AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses
AURKA inhibitor-induced PD-L1 upregulation impairs antitumor immune responses Open
Introduction Tumor immunotherapy targeting PD-L1 has emerged as one of the powerful tools for tumor therapy. Numerous studies indicate that tumor-targeted drugs critically have an influence on the interaction between the immune system and …
View article: Klotho reduces the risk of osteoporosis in postmenopausal women: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES)
Klotho reduces the risk of osteoporosis in postmenopausal women: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) Open
View article: Design Method and Performance Study of Insensitive Bridge Wire
Design Method and Performance Study of Insensitive Bridge Wire Open
An insensitive “fishbone” bridge wire was designed by dividing the bridge wire into a heat collection zone and a heat dissipation zone, leading to the improved safety and reliability of initiating explosive devices. The surface temperature…
View article: Correction to: The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma
Correction to: The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma Open
View article: GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies
GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies Open
Introduction Epstein-Barr virus (EBV) is a widely spread pathogen associated with lymphoproliferative diseases, B/ T/ NK cell lymphomas, nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). EBV lytic reactivations contribute to the g…
View article: Klotho Reduces the Risk of Osteoporosis in Postmenopausal Women: A cross-sectional Study of the National Health and Nutrition Examination Survey (NHANES)
Klotho Reduces the Risk of Osteoporosis in Postmenopausal Women: A cross-sectional Study of the National Health and Nutrition Examination Survey (NHANES) Open
Background: We explored a convenient and accurate factor to predict the risk factors of osteoporosis (OP) in postmenopausal women based on the study of the database. Methods: This is a retrospective study. We searched and collected the dat…
View article: Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model
Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model Open
View article: Value of machine learning algorithms for predicting diabetes risk: A subset analysis from a real‐world retrospective cohort study
Value of machine learning algorithms for predicting diabetes risk: A subset analysis from a real‐world retrospective cohort study Open
Aims/Introduction To compare the application value of different machine learning (ML) algorithms for diabetes risk prediction. Materials and Methods This is a 3‐year retrospective cohort study with a total of 3,687 participants being inclu…
View article: Surgical Methods and Social Factors Are Associated With Long-Term Survival in Follicular Thyroid Carcinoma: Construction and Validation of a Prognostic Model Based on Machine Learning Algorithms
Surgical Methods and Social Factors Are Associated With Long-Term Survival in Follicular Thyroid Carcinoma: Construction and Validation of a Prognostic Model Based on Machine Learning Algorithms Open
Background This study aimed to establish and verify an effective machine learning (ML) model to predict the prognosis of follicular thyroid cancer (FTC), and compare it with the eighth edition of the American Joint Committee on Cancer (AJC…
View article: Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery
Reassembling of albumin-bound paclitaxel mitigates myelosuppression and improves its antitumoral efficacy via neutrophil-mediated targeting drug delivery Open
Albumin-bound paclitaxel (abPTX) has been widely used in cancer treatment. However, dose-related side effects, such as myelosuppression, restrict its clinical application. Cell-based targeting drug delivery is a promising way to mitigate s…
View article: Modeling Population Human Mobility with Dynamic Mode Decomposition
Modeling Population Human Mobility with Dynamic Mode Decomposition Open
Human mobility research concerns spatiotemporal individual and population movement. Accurate modeling and prediction of human mobility can provide opportunities to monitor, manage and optimize human movement for improved social-economic be…
View article: The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β
The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β Open
Transforming growth factor-β (TGF-β) plays a critical role in regulating cell growth and differentiation. Epithelial to mesenchymal transition (EMT) induced by TGF-β promotes cancer cell migration, invasion, and proliferation. Pirfenidone …
View article: The role of necroptosis in disease and treatment
The role of necroptosis in disease and treatment Open
Necroptosis, a distinctive type of programmed cell death different from apoptosis or necrosis, triggered by a series of death receptors such as tumor necrosis factor receptor 1 (TNFR1), TNFR2, and Fas. In case that apoptosis process is blo…
View article: Co-immunizing with HMGB1 enhances anti-tumor immunity of B7H3 vaccine in renal carcinoma
Co-immunizing with HMGB1 enhances anti-tumor immunity of B7H3 vaccine in renal carcinoma Open
Metastatic renal carcinoma is a kind of tumor with high degree of malignancy, but there are no effective treatment methods and strategies at present. In this study, we designed a folate-grafted PEI600-CyD (H1) nanoparticle-mediated DNA vac…