Wangjun Liao
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View article: Exercise-induced hypertrophic preconditioning alleviates myocardial ischemic injury through trained immunity of macrophages
Exercise-induced hypertrophic preconditioning alleviates myocardial ischemic injury through trained immunity of macrophages Open
View article: Table S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S4. Primer sequences
View article: Figure S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S4 High stiffness-induced HSCs promote FAO metabolism in colon cancer cells through secreting FFAs.
View article: Table S3 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S3 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S3. Reagents or Resources
View article: Figure S5 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S5 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S5 Matrix stiffness activates lipolysis in HSCs.
View article: Table S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S1. Patient Information
View article: Supplementary Methods from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Supplementary Methods from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Methods
View article: Table S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S2. The composition of polyacrylamide gels
View article: Figure S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S1 Increased ECM deposition and active FAO metabolism induce Bevacizumab resistance in liver metastases.
View article: Figure S8 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S8 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S8 Matrix stiffness induced lipid crosstalk between HSCs and colon cancer cells promote tumor proliferation and angiogenesis.
View article: Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts
Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts Open
Premature senescent fibroblasts (PSFs) play an important role in regulating the fibrotic process after myocardial infarction (MI), but their effect on cardiac fibrosis remains unknown. Here, the investigation is aimed to determine whether …
View article: Neutrophil-to-lymphocyte ratio-based prognostic score can predict outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy plus chemotherapy
Neutrophil-to-lymphocyte ratio-based prognostic score can predict outcomes in patients with advanced non-small cell lung cancer treated with immunotherapy plus chemotherapy Open
The noninvasive NF score, combining NLR > 3.3 and FIB > 3.196, was superior to PD-L1 estimated from tumor tissue in predicting the efficacy and prognosis of first-line ICI plus chemotherapy in advanced NSCLC patients. The noninvasive NTP s…
View article: Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC
Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC Open
Background We aimed to develop a machine learning model based on intratumoral and peritumoral 18 F-FDG PET/CT radiomics to non-invasively and dynamically predict the response to immunotherapy in non-small cell lung cancer (NSCLC). Methods …
View article: A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve
A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve Open
Background The mechanisms underlying cardiac remodeling in aortic valvular (AoV) disease remain poorly understood, partially due to the insufficiency of appropriate preclinical animal models. Here, we present a novel murine model of aortic…
View article: Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation
Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation Open
Background Patients with microsatellite stable (MSS) colorectal cancer (CRC) often display resistance to immunotherapy. Epidermal growth factor receptor (EGFR)-targeted therapies have shown potential in enhancing immunotherapy, yet clinica…
View article: Identifying practical adaptations to health risks from extreme weather events for multi-actors
Identifying practical adaptations to health risks from extreme weather events for multi-actors Open
To address escalating health risk posed by extreme weather due to climate change, it’s particularly important to identify tailored adaptation measures for various actors, enabling them to respond quickly and effectively. However, there rem…
View article: Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas
Pan-cancer analysis of the transcriptional expression of histone acetylation enzymes in solid tumors defines a new classification scheme for gliomas Open
Introduction The altered expression of genes encoding histone acetyltransferases (HATs) and histone deacetylases (HDACs) has been implicated in the tumorigenesis and progression of various solid tumors. However, systematic characterization…
View article: ATOH8 upregulated by IL-6/STAT3 attenuates endoplasmic reticulum stress and promotes oxaliplatin resistance in gastric cancer
ATOH8 upregulated by IL-6/STAT3 attenuates endoplasmic reticulum stress and promotes oxaliplatin resistance in gastric cancer Open
Gastric cancer (GC) is a highly malignant tumor, and oxaliplatin is widely used in its chemotherapy. However, drug resistance limits its clinical effectiveness. This study aimed to identify potential therapeutic strategies to overcome oxal…
View article: Upcycling of PET into Electroactive Poly(urethane-urea) Catalysts with In-Situ Anchored AuNPs for Efficient Water Remediation and Recovery
Upcycling of PET into Electroactive Poly(urethane-urea) Catalysts with In-Situ Anchored AuNPs for Efficient Water Remediation and Recovery Open
View article: Cholecystectomy Confers Long-Term Cardioprotection：Multi-Dimensional Evidence from Epidemiological, Genetic, Machine Learning, and Mechanistic Analyses
Cholecystectomy Confers Long-Term Cardioprotection：Multi-Dimensional Evidence from Epidemiological, Genetic, Machine Learning, and Mechanistic Analyses Open
View article: CTSK-Mediated Macrophage Reprogramming Restricts Disitamab Vedotin Efficacy in HER2-Positive Colorectal Cancer
CTSK-Mediated Macrophage Reprogramming Restricts Disitamab Vedotin Efficacy in HER2-Positive Colorectal Cancer Open
View article: Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0
Enhancing immuno-oncology investigations through multidimensional decoding of tumor microenvironment with IOBR 2.0 Open
The use of large transcriptome datasets has greatly improved our understanding of the tumor microenvironment (TME) and helped develop precise immunotherapies. The growing application of multi-omics, single-cell RNA sequencing (scRNA-seq), …
View article: Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy
Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy Open
Drug resistance limits the efficacy of chemotherapy for colorectal cancer liver metastasis (CRLM). However, the evolution of CRLM during drug treatment remains poorly elucidated. Multi-omics and treatment response data from 115 samples of …
View article: The first-in-class bispecific antibody IBI318 (LY3434172) targeting PD-1 and PD-L1 in patients with advanced tumors: a phase Ia/Ib study
The first-in-class bispecific antibody IBI318 (LY3434172) targeting PD-1 and PD-L1 in patients with advanced tumors: a phase Ia/Ib study Open
View article: Platelet-specific TGFβ deficiency aggravates atherosclerosis, vascular inflammation and hypercholesterolemia in mice
Platelet-specific TGFβ deficiency aggravates atherosclerosis, vascular inflammation and hypercholesterolemia in mice Open
Background Atherosclerosis involves inflammatory and thrombotic mechanisms, to which platelets, CD4+ T effector cells, and transforming growth factor β (TGFβ) all contribute importantly. Platelets are the principal source of cir…
View article: CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation
CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation Open
Aims CircRNAs could regulate macrophage pyroptosis, which has the potential in promoting the synergistic effect of inflammation and matrix metalloproteinase (MMP) activity in abdominal aortic aneurysm (AAA). But the roles of circRNAs in mo…
View article: RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner
RNA‐Binding Protein Hnrnpa1 Triggers Daughter Cardiomyocyte Formation by Promoting Cardiomyocyte Dedifferentiation and Cell Cycle Activity in a Post‐Transcriptional Manner Open
Stimulating cardiomyocyte (CM) dedifferentiation and cell cycle activity (DACCA) is essential for triggering daughter CM formation. In addition to transcriptional processes, RNA‐binding proteins (RBPs) are emerging as crucial post‐transcri…
View article: Tumor microenvironment assessment-based signatures for predicting response to immunotherapy in non-small cell lung cancer
Tumor microenvironment assessment-based signatures for predicting response to immunotherapy in non-small cell lung cancer Open
View article: Radiofrequency ablation: mechanisms and clinical applications
Radiofrequency ablation: mechanisms and clinical applications Open
Radiofrequency ablation (RFA), a form of thermal ablation, employs localized heat to induce protein denaturation in tissue cells, resulting in cell death. It has emerged as a viable treatment option for patients who are ineligible for surg…
View article: Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte
Tert promotes cardiac regenerative repair after MI through alleviating ROS-induced DNA damage response in cardiomyocyte Open