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View article: Figure S3 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S3 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S3 Conditioned medium derived from HSCs cultured on the stiff substrates upregulates FAO metabolism in colon cancer cells.
View article: Table S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S4. Primer sequences
View article: Figure S7 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S7 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S7 Matrix stiffness induces lipolysis in HSCs via activating the FAK-YAP signaling pathway.
View article: Figure S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S4 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S4 High stiffness-induced HSCs promote FAO metabolism in colon cancer cells through secreting FFAs.
View article: Table S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S1. Patient Information
View article: Table S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Table S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Supplementary Table S2. The composition of polyacrylamide gels
View article: Figure S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S2 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure.S2 HSCs are essential for matrix stiffness-mediated FAO metabolic reprogramming in colon cancer cells.
View article: Figure S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases
Figure S1 from Matrix Stiffness Triggers Lipid Metabolic Cross-talk between Tumor and Stromal Cells to Mediate Bevacizumab Resistance in Colorectal Cancer Liver Metastases Open
Figure. S1 Increased ECM deposition and active FAO metabolism induce Bevacizumab resistance in liver metastases.
View article: Ultrasensitive SERS detection and efficient flotation removal of nanoplastics from water using bubble-spouting micromotor swarms
Ultrasensitive SERS detection and efficient flotation removal of nanoplastics from water using bubble-spouting micromotor swarms Open
Nanoplastics are ubiquitous in aquatic environments. Most of the nanoplastics suspend in the water column, facilitating their transportation and increasing their influence on the ecosystems. Owing to their small size and good dispersion in…
View article: Construction and validation of a nomogram for screening for sarcopenia in patients with osteoporotic vertebral compression fracture
Construction and validation of a nomogram for screening for sarcopenia in patients with osteoporotic vertebral compression fracture Open
View article: Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials
Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials Open
Immune checkpoint inhibitors (ICIs) are widely used to treat advanced non‐small cell lung cancer (NSCLC). However, it remains crucial to identify patients who are unlikely to benefit from immunotherapy and to explore potential combination …
View article: Stroke in Individuals With Hypertrophic Cardiomyopathy and Sleep Apnea
Stroke in Individuals With Hypertrophic Cardiomyopathy and Sleep Apnea Open
View article: Estimating and testing blip effects of treatments in sequence via standardized point effects of treatments
Estimating and testing blip effects of treatments in sequence via standardized point effects of treatments Open
In longitudinal studies, treatments are often assigned in the form of a sequence to achieve a certain outcome of interest. The blip effect of treatment in sequence is the net effect of treatment on the outcome. In this article, we introduc…
View article: Artificial Intelligence‐Based Multimodal Prediction of Postoperative Adjuvant Immunotherapy Benefit in Urothelial Carcinoma: Results From the Phase III, Multicenter, Randomized, IMvigor010 Trial
Artificial Intelligence‐Based Multimodal Prediction of Postoperative Adjuvant Immunotherapy Benefit in Urothelial Carcinoma: Results From the Phase III, Multicenter, Randomized, IMvigor010 Trial Open
While circulating tumor DNA (ctDNA) testing has demonstrated utility in identifying muscle‐invasive urothelial carcinoma (MIUC) patients likely to benefit from adjuvant immunotherapy, the prognostic value of transcriptome data from surgica…
View article: Exploring the prognostic value and immune landscape of EGLN1 in colorectal cancer: insights from bioinformatics analysis
Exploring the prognostic value and immune landscape of EGLN1 in colorectal cancer: insights from bioinformatics analysis Open
In summary, our findings position EGLN1 as a promising multi-faceted biomarker in CRC, with implications for prognosis, immune microenvironment modulation, and potential therapeutic targeting.
View article: Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels
Hsp90 C-terminal domain inhibition enhances ferroptosis by disrupting GPX4-VDAC1 interaction to increase HMOX1 release from oligomerized VDAC1 channels Open
View article: Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer
Immunotyping the Tumor Microenvironment Reveals Molecular Heterogeneity for Personalized Immunotherapy in Cancer Open
The tumor microenvironment (TME) significantly influences cancer prognosis and therapeutic outcomes, yet its composition remains highly heterogeneous, and currently, no highly accessible, high‐throughput method exists to define it. To addr…
View article: Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts
Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts Open
Premature senescent fibroblasts (PSFs) play an important role in regulating the fibrotic process after myocardial infarction (MI), but their effect on cardiac fibrosis remains unknown. Here, the investigation is aimed to determine whether …
View article: A body shape index for visceral fat and its changes predict cardiovascular outcomes of heart failure with preserved ejection fraction
A body shape index for visceral fat and its changes predict cardiovascular outcomes of heart failure with preserved ejection fraction Open
Aims This study aimed to investigate the relationship between visceral adipose tissue (VAT), measured using a body shape index (ABSI), and outcomes in patients with heart failure with preserved ejection fraction (HFpEF). Methods ABSI data …
View article: Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC
Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC Open
Background We aimed to develop a machine learning model based on intratumoral and peritumoral 18 F-FDG PET/CT radiomics to non-invasively and dynamically predict the response to immunotherapy in non-small cell lung cancer (NSCLC). Methods …
View article: A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve
A murine model of aortic regurgitation generated by trans‐apical wire destruction of the aortic valve Open
Background The mechanisms underlying cardiac remodeling in aortic valvular (AoV) disease remain poorly understood, partially due to the insufficiency of appropriate preclinical animal models. Here, we present a novel murine model of aortic…
View article: Exploration of Mulan's Employment of Masculine Language in Mulan (Disney 1998)
Exploration of Mulan's Employment of Masculine Language in Mulan (Disney 1998) Open
This paper examines the unique employment of masculine language by the character Mulan in Disney's 1998 film Mulan, underpinning its analysis with Judith Butler’s theory of gender performativity. Unlike traditional Disney princesses, Mulan…
View article: Cholecystectomy Confers Long-Term Cardioprotection：Multi-Dimensional Evidence from Epidemiological, Genetic, Machine Learning, and Mechanistic Analyses
Cholecystectomy Confers Long-Term Cardioprotection：Multi-Dimensional Evidence from Epidemiological, Genetic, Machine Learning, and Mechanistic Analyses Open
View article: CTSK-Mediated Macrophage Reprogramming Restricts Disitamab Vedotin Efficacy in HER2-Positive Colorectal Cancer
CTSK-Mediated Macrophage Reprogramming Restricts Disitamab Vedotin Efficacy in HER2-Positive Colorectal Cancer Open
View article: Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma
Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma Open
Excessive lipid accumulation promotes the occurrence and progression of hepatocellular carcinoma (HCC), accompanied by high levels of fatty acid synthetase (FASN) and more active lipogenesis. Heat shock protein 90 (Hsp90) acts as a chapero…
View article: Canagliflozin reverses doxorubicin-induced cardiotoxicity via restoration of autophagic homeostasis
Canagliflozin reverses doxorubicin-induced cardiotoxicity via restoration of autophagic homeostasis Open
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have been reported as successful for preventing doxorubicin (DOX) -induced cardiotoxicity (DIC), but the underlying mechanisms are elusive. This study aimed to determine whether canagliflo…
View article: Deciphering the Significance of Platelet‐Derived Chloride Ion Channel Gene (BEST3) Through Platelet‐Related Subtypes Mining for Non‐Small Cell Lung Cancer
Deciphering the Significance of Platelet‐Derived Chloride Ion Channel Gene (BEST3) Through Platelet‐Related Subtypes Mining for Non‐Small Cell Lung Cancer Open
This study investigates platelet‐related subtypes in non‐small cell lung cancer (NSCLC) and seeks to identify genes associated with prognosis, focusing on the clinical significance of the chloride ion channel gene BEST3. We utilised sequen…
View article: CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation
CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation Open
Aims CircRNAs could regulate macrophage pyroptosis, which has the potential in promoting the synergistic effect of inflammation and matrix metalloproteinase (MMP) activity in abdominal aortic aneurysm (AAA). But the roles of circRNAs in mo…
View article: Tumor microenvironment assessment-based signatures for predicting response to immunotherapy in non-small cell lung cancer
Tumor microenvironment assessment-based signatures for predicting response to immunotherapy in non-small cell lung cancer Open
View article: Dynamic single‐cell sequencing unveils the tumor microenvironment evolution of gastric cancer abdominal wall metastases during radiotherapy
Dynamic single‐cell sequencing unveils the tumor microenvironment evolution of gastric cancer abdominal wall metastases during radiotherapy Open
Although the combination of immunotherapy and radiotherapy (RT) for the treatment of malignant tumors has shown rapid development, the insight of how RT remodels the tumor microenvironment to prime antitumor immunity involves a complex int…