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View article: A pH‐Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury
A pH‐Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury Open
Acute kidney injury (AKI) represents a critical clinical condition marked by abrupt deterioration of renal function, primarily driven by oxidative stress, inflammation, and apoptosis. However, effective targeted therapies remain limited. H…
View article: Preventive wound drainage reduces esophageal fistula or infection after endoscopic resection of giant submucosal tumors in the esophagus
Preventive wound drainage reduces esophageal fistula or infection after endoscopic resection of giant submucosal tumors in the esophagus Open
Submucosal tunneling endoscopic resection (STER) has emerged as an innovative approach for the treatment of giant submucosal tumors (SMTs) in the esophagus. However, complications such as esophageal fistula or submucosal infection remain a…
View article: Deep learning-based recurrent laryngeal nerve detection during endoscopic thyroidectomy
Deep learning-based recurrent laryngeal nerve detection during endoscopic thyroidectomy Open
View article: Comparative spatial transcriptomics of pancreatic cancer with ductal and acinar origins in mouse models
Comparative spatial transcriptomics of pancreatic cancer with ductal and acinar origins in mouse models Open
View article: Case Report: Successful application of endoscopic biliary accessories in a patient with complete esophageal stricture
Case Report: Successful application of endoscopic biliary accessories in a patient with complete esophageal stricture Open
The endoscopic treatment of complete esophageal stricture presents a huge challenge. In instances where the esophageal lumen is nearly obliterated, preventing the passage of a dilating guide wire, conventional endoscopic bougie dilation is…
View article: Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of velvet antler in the treatment of chronic atrophic gastritis Open
Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experimen…
View article: Circulating exo-miRNA-27a-5p is a novel biomarker of the tofacitinib treatment response in rheumatoid arthritis
Circulating exo-miRNA-27a-5p is a novel biomarker of the tofacitinib treatment response in rheumatoid arthritis Open
This study suggests that circulating exo-miR-27a-5p is a novel non-invasive biomarker to monitor the response to tofacitinib treatment.
View article: Factors Influencing the symptom-to-contact Time in Patients with Peritoneal Dialysis-associated Peritonitis: A multi-center Retrospective Study
Factors Influencing the symptom-to-contact Time in Patients with Peritoneal Dialysis-associated Peritonitis: A multi-center Retrospective Study Open
Background Delays in seeking medical attention lead to delays in the initiation of antibiotic therapy, prolonging the duration of illness in patients with peritoneal dialysis-associated peritonitis (PDAP). However, there is little informat…
View article: Primary hyperparathyroidism during pregnancy: ultrasound as an accurate preoperative localization imaging modality
Primary hyperparathyroidism during pregnancy: ultrasound as an accurate preoperative localization imaging modality Open
Background Accurate identification of parathyroid lesions in primary hyperparathyroidism (PHPT) patients is essential for minimally invasive surgery during pregnancy. Materials and methods Patients who were diagnosed with PHPT during pregn…
View article: Primary exploration of cell-free DNA in the plasma of patients with parathyroid neoplasms using next-generation sequencing
Primary exploration of cell-free DNA in the plasma of patients with parathyroid neoplasms using next-generation sequencing Open
View article: Ultrasound diagnosis of parathyroid adenomas mimicking normal lymph nodes: microvascular clues
Ultrasound diagnosis of parathyroid adenomas mimicking normal lymph nodes: microvascular clues Open
MVFI more frequently identified polar vessels and rich vascularity in parathyroid adenomas, as well as hilar vessels in lymph nodes, compared to CDFI. This suggests that MVFI may play a better role in differentiating parathyroid adenomas f…
View article: Machine learning potential predictor of idiopathic pulmonary fibrosis
Machine learning potential predictor of idiopathic pulmonary fibrosis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a severe chronic respiratory disease characterized by treatment challenges and poor prognosis. Identifying relevant biomarkers for effective early-stage risk prediction is therefore of cr…
View article: Molecular Profiling Reveals the Malignant Potential in Solid Pseudopapillary Neoplasms of the Pancreas
Molecular Profiling Reveals the Malignant Potential in Solid Pseudopapillary Neoplasms of the Pancreas Open
View article: Glycomic profiling of parathyroid neoplasms via lectin microarray analysis
Glycomic profiling of parathyroid neoplasms via lectin microarray analysis Open
PC presented unique glycomic features and ACL may serve as a candidate diagnostic marker for PC.
View article: Network Pharmacology and Machine Learning Reveal Salidroside’s Mechanisms in Idiopathic Pulmonary Fibrosis Treatment
Network Pharmacology and Machine Learning Reveal Salidroside’s Mechanisms in Idiopathic Pulmonary Fibrosis Treatment Open
Experimental results suggest that SAL effectively ameliorates BLM-induced EMT and IPF, likely through the inhibition of IGF1, HIF-1α, and MAPK signaling pathways. This study holds potential translational prospects and may provide new persp…
View article: Antler blood enhances the ability of stem cell-derived exosomes to promote bone and vascular regeneration
Antler blood enhances the ability of stem cell-derived exosomes to promote bone and vascular regeneration Open
ALB enhances the ability of BMSCs-derived Exos to promote bone and vascular regeneration, which may be related to the up-regulation of miR-21-5p.
View article: The significance of an immunohistochemical marker-based panel in assisting the diagnosis of parathyroid carcinoma
The significance of an immunohistochemical marker-based panel in assisting the diagnosis of parathyroid carcinoma Open
View article: Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report
Long-term sustained clinical remission of peritoneal metastatic pancreatic ductal adenocarcinoma after sequential chemoradiation therapy: a case report Open
Patients with peritoneal metastatic pancreatic ductal adenocarcinoma (pmPDAC) with high-level serum carbohydrate antigens (CAs) always suffer extremely dismal prognosis, with a median survival of several months. Herein, we reported a case …
View article: Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment
Modulating ferroptosis sensitivity: environmental and cellular targets within the tumor microenvironment Open
Ferroptosis, a novel form of cell death triggered by iron-dependent phospholipid peroxidation, presents significant therapeutic potential across diverse cancer types. Central to cellular metabolism, the metabolic pathways associated with f…
View article: Heparin-induced thrombocytopenia thrombosis after pancreaticoduodenectomy without definitive prophylactic or therapeutic use of heparin: a case report
Heparin-induced thrombocytopenia thrombosis after pancreaticoduodenectomy without definitive prophylactic or therapeutic use of heparin: a case report Open
Heparin-induced thrombocytopenia thrombosis (HITT) is a rare and potentially life-threatening complication after abdominal surgery, and it always occurs after the prophylactic or therapeutic use of heparin. HITT after pancreaticoduodenecto…
View article: Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm Open
Pancreatic cystic neoplasms (PCNs) are recognized as precursor lesions of pancreatic cancer, with a marked increase in prevalence. Early detection of malignant PCNs is crucial for improving prognosis; however, current diagnostic methods ar…
View article: A new prognostic model for glioblastoma multiforme based on coagulation-related genes
A new prognostic model for glioblastoma multiforme based on coagulation-related genes Open
BACKGROUND: Glioblastoma multiforme (GBM) is the most aggressive, common, and lethal type of primary brain tumor. Multiple cancers have been associated with abnormalities in the coagulation system that facilitate tumor invasion and metasta…
View article: <scp>miR</scp>‐3133 inhibits gastrointestinal cancer progression through activation of Hippo and p53 signalling pathways via multi‐targets
<span>miR</span>‐3133 inhibits gastrointestinal cancer progression through activation of Hippo and p53 signalling pathways via multi‐targets Open
Background Malignant cell growth and chemoresistance, the main obstacles in treating gastrointestinal cancer (GIC), rely on the Hippo and p53 signalling pathways. However, the upstream regulatory mechanisms of these pathways remain complex…
View article: Can we skip technetium-99 m sestamibi scintigraphy in pediatric primary hyperparathyroidism patients with positive neck ultrasound results?
Can we skip technetium-99 m sestamibi scintigraphy in pediatric primary hyperparathyroidism patients with positive neck ultrasound results? Open
View article: Qualitative and quantitative superb vascular imaging in the diagnosis of thyroid nodules ≤10 mm based on the Chinese Thyroid Imaging Reporting and Data System 4 (C-TIRADS 4)
Qualitative and quantitative superb vascular imaging in the diagnosis of thyroid nodules ≤10 mm based on the Chinese Thyroid Imaging Reporting and Data System 4 (C-TIRADS 4) Open
There is no statistical difference between qualitative and quantitative SMI in the diagnosis of C-TR4 TNs. The combination of qualitative and quantitative SMI may have the potential to manage diagnosis of C-TR4 nodules.
View article: Diabetes management in patients undergoing total pancreatectomy: A single center cohort study
Diabetes management in patients undergoing total pancreatectomy: A single center cohort study Open
Background Total pancreatectomy (TP) has been increasingly performed in recent years. However, studies on diabetes management after TP during different postoperative periods are still limited. Objectives This study aimed to evaluate the gl…
View article: Prediction of multiglandular parathyroid disease in primary hyperparathyroidism using ultrasound and clinical features
Prediction of multiglandular parathyroid disease in primary hyperparathyroidism using ultrasound and clinical features Open
Background Identification of multigland disease (MGD) in primary hyperparathyroidism (PHPT) patients is essential for minimally invasive surgical decision-making. Objective To develop a nomogram based on US findings and clinical factors to…
View article: Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T Open
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies in most solid neoplasms, which necessitates …
View article: Identifying the diagnostic value of inflammatory genes in intracranial aneurysms based on machine learning
Identifying the diagnostic value of inflammatory genes in intracranial aneurysms based on machine learning Open
Background Intracranial aneurysm (IA) is a cerebrovascular disease that can be caused by a variety of factors. Clinical trials have indicated that inflammation and inflammatory cells play critical roles in the pathophysiology of IA. Noneth…
View article: A new prognostic model for GBM based on coagulation-related genes
A new prognostic model for GBM based on coagulation-related genes Open
Background: Glioblastoma multiforme (GBM) has the highest aggressiveness and is the most common and lethal types of primary brain tumor. Multiple cancers have been associated with abnormalities in the coagulation system that facilitate tum…