Liaoxun Lu
YOU?
Author Swipe
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and mol…
View article: Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
View article: Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Author response: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1+ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and mol…
View article: Dock8 regulates Th2 cell differentiation through ANXA1
Dock8 regulates Th2 cell differentiation through ANXA1 Open
View article: Author Correction: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
Author Correction: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells Open
View article: Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progression
Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progression Open
Background Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellul…
View article: A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo
A CARMIL2 gain-of-function mutation suffices to trigger most CD28 costimulatory functions in vivo Open
Naive T cell activation requires both TCR and CD28 signals. The CARMIL2 cytosolic protein enables CD28-dependent activation of the NF-κB transcription factor via its ability to link CD28 to the CARD11 adaptor protein. Here, we developed mi…
View article: Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells
Tyrosinase in melanoma inhibits anti-tumor activity of PD-1 deficient T cells Open
View article: RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways
RNF167 mediates atypical ubiquitylation and degradation of RLRs via two distinct proteolytic pathways Open
The precise regulation of the RIG-I-like receptors (RLRs)-mediated type I interferon (IFN-I) activation is crucial in antiviral immunity and maintaining host immune homeostasis in the meantime. Here, we identify an E3 ubiquitin ligase, nam…
View article: Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4<sup>+</sup> T cells
Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4<sup>+</sup> T cells Open
Dedicator of cytokinesis 8 (DOCK8) deficiency is a primary immunodeficiency disease caused by mutations in exon 45 of the DOCK8 gene. The clinical signs primarily consist of increased serum IgE levels, eczema, repeated skin infections, all…
View article: Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis
Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis Open
T lymphopenia, occurring in the early phase of sepsis in response to systemic inflammation, is commonly associated with morbidity and mortality of septic infections. We have previously shown that a sufficient number of T cells is required …
View article: Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis
Pathology and molecular mechanisms of Schistosoma japonicum-associated liver fibrosis Open
Schistosomiasis has been widely disseminated around the world, and poses a significant threat to human health. Schistosoma eggs and soluble egg antigen (SEA) mediated inflammatory responses promote the formation of egg granulomas and liver…
View article: A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vγ6 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment
A Murine Point Mutation of Sgpl1 Skin Is Enriched With Vγ6 IL17-Producing Cell and Revealed With Hyperpigmentation After Imiquimod Treatment Open
Sphingosine-1-phosphate lyase is encoded by the Sgpl1 gene, degrades S1P, and is crucial for S1P homeostasis in animal models and humans. S1P lyase deficient patients suffer from adrenal insufficiency, severe lymphopenia, and skin disorder…
View article: Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice
Excessive immunosuppression by regulatory T cells antagonizes T cell response to schistosome infection in PD-1-deficient mice Open
Schistosomiasis is caused by parasitic flatworms known as schistosomes and affects over 200 million people worldwide. Prevention of T cell exhaustion by blockade of PD-1 results in clinical benefits to cancer patients and clearance of vira…
View article: sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification Open
Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency. However, experimental evi…
View article: GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice Open
Significance This study reports that the intermediate filament protein GFAP is modified with protein palmitoylation. Increased GFAP expression and palmitoylation is involved in astrocyte proliferation and astrogliosis. We demonstrate that …
View article: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis
Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis Open
Zdhhc family genes are composed of 24 members that regulate palmitoylation, a post-translational modification process for proteins. Mutations in genes that alter palmitoylation or de-palmitoylation could result in neurodegenerative disease…
View article: An inducible model for specific neutrophil depletion by diphtheria toxin in mice
An inducible model for specific neutrophil depletion by diphtheria toxin in mice Open
View article: Loss of natural resistance to schistosome in T cell deficient rat
Loss of natural resistance to schistosome in T cell deficient rat Open
Schistosomiasis is among the major neglected tropical diseases and effective prevention by boosting the immune system is still not available. T cells are key cellular components governing adaptive immune response to various infections. Whi…
View article: Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts
Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts Open
Extracellular matrix mineralization is critical for osteogenesis, and its dysregulation could result in osteoporosis and vascular calcification. IKK/NF-κB activation inhibits differentiation of osteoblasts, and reduces extracellular matrix…
View article: Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics
Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics Open
View article: The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis
The three members of the Vav family proteins form complexes that concur to foam cell formation and atherosclerosis Open
During foam cell formation and atherosclerosis development, the scavenger receptor CD36 plays critical roles in lipid uptake and triggering of atherogenicity via the activation of Vav molecules. The Vav family includes three highly conserv…
View article: Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice
Precise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice Open
It is a tempting goal to identify causative genes underlying phenotypic differences among inbred strains of mice, which is a huge reservoir of genetic resources to understand mammalian pathophysiology. In particular, the wild-derived mouse…
View article: A severe atherosclerosis mouse model on the resistant NOD background
A severe atherosclerosis mouse model on the resistant NOD background Open
Atherosclerosis is a complex disease affecting arterial blood vessels and blood flow that could result in a variety of life-threatening consequences. Disease models with diverged genomes are necessary for understanding the genetic architec…