Libin Liu
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Levothyroxine dose prediction post-thyroidectomy for differentiated thyroid carcinoma Open
Objective To address the overestimation of levothyroxine (L-T4) doses in conventional weight-based regimens for individuals who are overweight and obese, this study aimed to identify the most predictive body weight metrics and establish an…
Comparison of logistic regression and artificial neural network models for predicting hypoglycemia in non-ICU inpatients with diabetes Open
Not applicable.
Association between group-based trajectory modeling of blood glucose and acute delirium incidence in critically ill patients: a retrospective cohort study based on the MIMIC-IV database Open
Delirium is a frequent complication in critically ill patients and is associated with adverse outcomes such as long-term cognitive impairment and increased mortality. The relationship between the dynamic changes in blood glucose and the on…
Mesenchymal stem cells’ exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats Open
Introduction: Irritable bowel syndrome (IBS) is a prevalent chronic functional gastrointestinal disorder characterized by visceral hypersensitivity (VH), affecting over 10% of the global population. Current treatments for IBS have notable …
View article: Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study
Clinical Features of Chinese Patients with Thyroid Eye Disease: A Multicenter Retrospective Study Open
Background: Thyroid eye disease (TED) is a debilitating autoimmune disorder linked to thyroid dysfunction. There is limited knowledge of TED in Asian populations. This multicenter study characterizes the clinical features and treatment res…
Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice Open
Objective This study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice. Methods db/db diabetic mice were administered PAItrap3 (5.7 mg/kg/day, IV) for 21 con…
Analysis of influencing factors and mediating effects of diabetes self-management behavior in patients with type 2 diabetes mellitus Open
Background: Few studies have investigated the relationship among self-management, self-efficacy, and dietary behavior compliance. We evaluated type 2 diabetes mellitus (T2DM) self-management behavior and analyzed whether dietary behavior c…
Mitophagy activation by rapamycin enhances mitochondrial function and cognition in 5×FAD mice Open
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by severe mitochondrial dysfunction, which is an intracellular process that is significantly compromised in the early stages of AD. Mitophagy, the selective rem…
GLP-1 Receptor Agonist Improves Mitochondrial Energy Status and Attenuates Nephrotoxicity In Vivo and In Vitro Open
High-sugar and high-fat diets cause significant harm to health, especially via metabolic diseases. In this study, the protective effects of the antidiabetic drug exenatide (synthetic exendin-4), a glucagon-like peptide 1 (GLP-1) receptor a…
Role of the score for the targeting of atrial fibrillation (STAF) combined with D-dimer in screening ischemic stroke patients with atrial fibrillation Open
Background: We aim to explore the effect of the score for the targeting of atrial fibrillation (STAF) combined with the serum D-dimer (DD) level in screening acute ischemic stroke patients with atrial fibrillation (AF). Methods: This study…
Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus Open
This is an observational, retrospective, single-center study aimed to determine whether the free triiodothyronine (FT3) to free thyroxine (FT4) ratio was related to acute myocardial infarction (AMI) prognosis in individuals with type 2 dia…
Mito-TEMPO, a mitochondria-targeted antioxidant, improves cognitive dysfunction due to hypoglycemia: An association with reduced pericyte loss and blood-brain barrier leakage Open
Hypoglycemia is associated with cognitive dysfunction, however, the exact mechanisms have not been elucidated. Our previous study found that severe hypoglycemia can lead to cognitive dysfunction in a type 1 diabetes (T1D) mouse model after…
View article: Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC–MS-Based Untargeted Metabolomics Study
Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC–MS-Based Untargeted Metabolomics Study Open
Background Recurrent hypoglycemia (RH) is well known to impair awareness of hypoglycemia and increase the risk of severe hypoglycemia; the underlying mechanism requires further understanding. We aimed to investigate the metabolic character…
View article: Lactoferrin ameliorates myocardial fibrosis by inhibiting inflammatory response via the AMPK/NF-κB pathway in aged mice
Lactoferrin ameliorates myocardial fibrosis by inhibiting inflammatory response via the AMPK/NF-κB pathway in aged mice Open
Cardiac fibrosis is more likely to promote the development of heart failure in the elderly. However, effective prevention and improvement of cardiac fibrosis are lacking. Here, we investigated the ameliorative effect of lactoferrin (LF) on…
Difference in Gastrointestinal Risk Associated with Use of GLP-1 Receptor Agonists: A Real-World Pharmacovigilance Study Open
Yu Zhou,1 Mingyu Chen,1 Libin Liu,2 Zhou Chen1 1Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Endocrinology, Fujian Medical Un…
View article: Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice Is Associated With Pericyte and Blood–Brain Barrier Dysfunction
Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice Is Associated With Pericyte and Blood–Brain Barrier Dysfunction Open
Background: Severe hypoglycemia can cause cognitive impairment in diabetic patients, but the underlying molecular mechanism remains unclear. Objective: To assess the effect of severe hypoglycemia on cognitive function in diabetic mice to c…
View article: Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice is Associated with Pericyte and Blood–Brain Barrier Dysfunction
Severe Hypoglycemia Contributing to Cognitive Dysfunction in Diabetic Mice is Associated with Pericyte and Blood–Brain Barrier Dysfunction Open
Background: Severe hypoglycemia can cause cognitive impairment in diabetic patients, but the underlying molecular mechanism remains unclear. Objective: To assess the effect of severe hypoglycemia on cognitive function in diabetic mice to c…
Liraglutide improves cognitive function by reducing amyloid-beta peptide accumulation and inhibiting inflammation in 5×FAD mice Open
The glucagon-like peptide-1 analog, liraglutide, has been shown to be effective in Alzheimer’s disease (AD); however, the underlying mechanism remains unknown. In this study, we evaluated the effects of liraglutide (25 nmol/day for 8 weeks…
View article: Development and Validation of a Prediction Model for Elevated Arterial Stiffness in Chinese Patients With Diabetes Using Machine Learning
Development and Validation of a Prediction Model for Elevated Arterial Stiffness in Chinese Patients With Diabetes Using Machine Learning Open
Background Arterial stiffness assessed by pulse wave velocity is a major risk factor for cardiovascular diseases. The incidence of cardiovascular events remains high in diabetics. However, a clinical prediction model for elevated arterial …
View article: The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65
The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65 Open
Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure (BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed …
Correlation between Thyroid Homeostasis and Obesity in Subclinical Hypothyroidism: Community-Based Cross-Sectional Research Open
Objective. It remains unknown whether obesity has an effect on the pituitary-thyroid feedback control axis in subclinical hypothyroidism (SCH). We aimed to investigate the association of thyroid homeostasis with obesity in a SCH population…
View article: Hyperthyroidism Prevalence in China After Universal Salt Iodization
Hyperthyroidism Prevalence in China After Universal Salt Iodization Open
Background Universal salt iodization (USI) was implemented in mainland China in 1996. The prevalence of hyperthyroidism and its risk factors now require examination. Methods Data were acquired from a nationwide Thyroid, Iodine, and Diabete…
View article: The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study
The Effect of Increased Iodine Intake on Serum Thyrotropin: A Cross-Sectional, Chinese Nationwide Study Open
Background: Subclinical hypothyroidism is diagnosed based on serum thyrotropin (TSH) reference intervals, which in turn are affected by many factors. Methods: Data were acquired from a Chinese nationally representative cross-sectional stud…