Lei Song
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View article: Assessing the economic burden and health-related quality of life in chinese patients with fibrodysplasia ossificans progressiva: a questionnaire survey analysis
Assessing the economic burden and health-related quality of life in chinese patients with fibrodysplasia ossificans progressiva: a questionnaire survey analysis Open
Background Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, disabling genetic disorder condition that lacks real-world evidence on disease burden. This study aims to investigate the basic characteristics, diagnostic status, pr…
View article: Systolic Dyssynchrony Index in Hypertrophic Cardiomyopathy
Systolic Dyssynchrony Index in Hypertrophic Cardiomyopathy Open
The SDI was more capable of assessing mechanical dyssynchrony and detecting NSVT in HCM patients compared with MD. The SDI might serve to identify HCM patients eligible for Class IIa ICD-COR according to current guidelines.
View article: An integrated framework for the prediction of axial offset anomaly in pressurized water reactors
An integrated framework for the prediction of axial offset anomaly in pressurized water reactors Open
During the operation of pressurized water reactors, erosion products can be deposited on the surfaces of the fuel rods, and these deposits lead to enrichment of boric acid, which influences the power distribution along the axial direction …
View article: Patterns of left ventricular trabeculation in hypertrophic cardiomyopathy
Patterns of left ventricular trabeculation in hypertrophic cardiomyopathy Open
The distribution pattern of LV trabeculation was inhomogeneous and asymmetric in HCM. A greater extent of LV trabeculation was associated with poor prognosis. The progression of LV trabeculation might be the natural course of HCM.
View article: An Empirical Analysis of Buy Now, Pay Later Mechanism and Its Impact on Customer Retention in Digital Commerce
An Empirical Analysis of Buy Now, Pay Later Mechanism and Its Impact on Customer Retention in Digital Commerce Open
The "Buy Now, Pay Later" (BNPL) mechanism has transformed e-commerce payment systems by providing consumers with enhanced financial flexibility. This study examines the influence of four key factors—interest rate, customer age, credit limi…
View article: Diagnostic yield of updated indications for endomyocardial biopsy and its clinical predictors in a Chinese cohort
Diagnostic yield of updated indications for endomyocardial biopsy and its clinical predictors in a Chinese cohort Open
Introduction: The challenging and restrictive settings have been proposed in the updated indications for endomyocardial biopsy (EMB), but no data shows its performance. This study aimed to evaluate the diagnostic yield and find its clinica…
View article: Somatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling
Somatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling Open
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, often caused by sarcomere gene mutations, though many sporadic cases remain genetically unexplained. Here we show that the somatic variant NAP1L1 p.D349E was inv…
View article: Clostridium butyricum CGMCC 0313.1 improves clinical outcomes of metabolic syndrome in schizophrenic patients
Clostridium butyricum CGMCC 0313.1 improves clinical outcomes of metabolic syndrome in schizophrenic patients Open
CB0313.1 helps enhance the clinical management of MS in schizophrenic patients.
View article: Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing
Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing Open
Background Spatial transcriptomics is a powerful tool that integrates molecular data with spatial information, thereby facilitating a deeper comprehension of tissue morphology and cellular interactions. In our study, we utilized cutting-ed…
View article: N-acetyltransferase 10 regulates UNC-51-like kinase 1 to reduce tubular cell injury and kidney stone formation
N-acetyltransferase 10 regulates UNC-51-like kinase 1 to reduce tubular cell injury and kidney stone formation Open
Objective: Among the most common chronic kidney diseases, kidney stones are second only to hypertension. Kidney stones pose a public health threat due to their increased incidence, high recurrence rate, and heavy economic burden. In this w…
View article: Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease—a large multicenter prospective study
Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease—a large multicenter prospective study Open
Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic …
View article: Long-Term Outcomes of Sex Differences in Three-Vessel Coronary Disease with Different Treatment Strategies: A Large Cohort Study
Long-Term Outcomes of Sex Differences in Three-Vessel Coronary Disease with Different Treatment Strategies: A Large Cohort Study Open
Aim: The information assessing sex differences in outcomes of patients with three-vessel coronary disease (TVD) after different treatment strategies is sparse. This study aimed to investigate long-term outcomes of TVD among women compared …
View article: Effect of high sensitivity C-Reactive Protein on Uric Acid-related Cardiometabolic Risk in Patients with Coronary Artery Disease— A Large Multicenter Prospective Study
Effect of high sensitivity C-Reactive Protein on Uric Acid-related Cardiometabolic Risk in Patients with Coronary Artery Disease— A Large Multicenter Prospective Study Open
Aims Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, syst…
View article: Spectrum and genotype–phenotype relationship of ALPK3 variants in Chinese patients with hypertrophic cardiomyopathy
Spectrum and genotype–phenotype relationship of ALPK3 variants in Chinese patients with hypertrophic cardiomyopathy Open
Our study supports that heterozygous ALPK3tv, but not APLK3 missense variants, are a genetic cause of HCM. Patients with HCM carrying ALPK3tv have a greater likelihood of developing apical HCM.
View article: Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2
Muscle-specific PGC-1α modulates mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2 Open
Our study demonstrated that PGC-1α modulated mitochondrial oxidative stress in aged sarcopenia through regulating Nrf2.
View article: Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy
Integrative analysis of transcriptome, DNA methylome, and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy Open
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and is characterized by primary left ventricular hypertrophy usually caused by mutations in sarcomere genes. The mechanism underlying cardiac remodeling in HCM re…
View article: CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder
CommonMind Consortium provides transcriptomic and epigenomic data for Schizophrenia and Bipolar Disorder Open
Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanis…
View article: The prophylactic antiemetic therapies in management of differentiated thyroid cancer patients with radioactive iodine therapy: a single-center, non-randomized clinical trial
The prophylactic antiemetic therapies in management of differentiated thyroid cancer patients with radioactive iodine therapy: a single-center, non-randomized clinical trial Open
Objective The present study was to investigate three different single-drug regimens to show which was more effective to reduce radioactive iodine therapy (RAI) associated nausea and vomiting, and to compare the occurrence of long-term gast…
View article: PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway
PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway Open
This research demonstrates that PGC-1α participates in regulating mitochondrial function in aged sarcopenia through effects on the Sestrin2-mediated mTORC1 pathway.
View article: Reinforced In-Context Black-Box Optimization
Reinforced In-Context Black-Box Optimization Open
Black-Box Optimization (BBO) has found successful applications in many fields of science and engineering. Recently, there has been a growing interest in meta-learning particular components of BBO algorithms to speed up optimization and get…
View article: Renal function alters the association of lipoprotein(a) with cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a prospective cohort study
Renal function alters the association of lipoprotein(a) with cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a prospective cohort study Open
Background and hypothesis Lipoprotein(a) [Lp(a)] and renal dysfunction are both independent risk factors for cardiovascular disease. However, it remains unclear whether renal function mediates the association between Lp(a) and cardiovascul…
View article: Experimental Study on the Filtration Characteristics and Sediment Distribution Influencing Factors of Sand Media Filters
Experimental Study on the Filtration Characteristics and Sediment Distribution Influencing Factors of Sand Media Filters Open
The sand media filter is a crucial component of micro-irrigation filtration systems. Investigating the effects of various factors on filtration performance and the migration patterns of sediment particles within the filter can enhance the …
View article: DHA promotes healthy adipose tissue remodeling and carbohydrate utilization in grass carp (Ctenopharyngodon idellus) and largemouth bass (Micropterus salmoides)
DHA promotes healthy adipose tissue remodeling and carbohydrate utilization in grass carp (Ctenopharyngodon idellus) and largemouth bass (Micropterus salmoides) Open
Due to the wide usage of high-carbohydrate diets in aquaculture, improving the ability of fish to utilize high-carbohydrate diets is one of the important issues in aquaculture. Adipose tissue is an essential organ for storing energy and pl…