Explanipedia

Diagnostic value of diffusion-weighted magnetic resonance imaging in differentiating benign and malignant fetal adrenal tumors Open

Xinhong Wei, Luyao Yang, Tao Gong, Jianbo Teng, Weitao Dou , et al. · 2025

Objective: To evaluate diffusion-weighted imaging (DWI) and the apparent diffusion coefficient (ADC) for the prenatal differentiation of fetal adrenal neuroblastoma (NB) from benign masses. Methods: This retrospective study analyzed prenat…

Chromatic aberration (Cc) corrected cryo-EM: The structure of pseudorabies virus (PRV) using both zero-loss and energy loss electrons Open

Jing Wu, Chundi Liu Chundi Liu, Aijun Wang, Yuzhu Gao, Libing Fu , et al. · 2025

Brain metastasis of pleuropulmonary blastoma: case reports Open

Schlitter He, Wen Zhao, Chao Duan, Libing Fu, Tong Yu , et al. · 2025

Although the optimal treatment regimen for CNS metastasis in PPB remains unclear, combined treatment approaches offer new possibilities. In particular, brain computed tomography (CT) or magnetic resonance imaging (MRI) scans should be cond…

Clinical and Prognostic Characteristics of 40 Cases of INI1-deficient Tumor in Children. A Single-Institute Experience from 2012 to 2022 Open

Shihan Zhang, Xisi Wang, Dawei Zhang, Huanmin Wang, Ming Ge , et al. · 2024

Background This study aims to summarize the clinical features and prognoses of INI1-deficient tumors in children. It further aims to analyze the high-risk factors affecting INI1-deficient tumors prognosis. Methods Clinical data from 40 chi…

Clinical Presentation, Management, and Diagnostic Performance of 2021 Criteria for Paraneoplastic Neurologic Syndromes in Childhood Open

Ji Zhou, M JIN, Yan Su, X W Zhuo, Libing Fu , et al. · 2024

OMS followed by rapidly progressive cerebellar ataxia are the most common forms of PNSs in children and are associated with neuroblastoma. An aggressive approach with multiple immunotherapies may improve the prognosis of neuroblastoma-asso…

Clinical features, treatment strategies, and prognosis of epithelioid inflammatory myofibroblastic sarcoma in children: a multicenter experience Open

Haiyan Cheng, Yu Lin, Jin Zhu, Hong Qin, Wei Yang , et al. · 2024

EIMS in children is extremely rare and clinically aggressive. The clinical presentation is nonspecific, and the initial diagnosis of the tumor is often large. Mutations in the ALK gene are common in EIMS. Surgery is the mainstay of …

Role of intestinal flora in the development of nonalcoholic fatty liver disease in children Open

Jing Zhang, Mengxuan Shi, Chunna Zhao, Guangcai Liang, Chuan Li , et al. · 2024

In China, 45% of adolescents with obesity develop fatty liver disease, a condition that increases the long-term risk of developing cirrhosis and liver cancer. Although the factors triggering nonalcoholic fatty liver disease (NAFLD) vary in…

Pediatric spindle cell/sclerosing rhabdomyosarcoma with FUS–TFCP2 fusion: a case report and literature review Open

Zishi Fang, Chao Duan, Shengcai Wang, Libing Fu, Peiyi Yang , et al. · 2024

Spindle cell/sclerosing RMS with FUS-TFCP2 fusion has its unique clinical characteristics and progression. It shows a marked skeletal predilection and an aggressive clinical course, typically resistant to traditional standard treatm…

Biallelic inactivation of SDHA results in comorbidity of pediatric recurrent neuroblastoma and gastric stromal tumor Open

Yang Shen, Shixuan Zhang, Wen Zhao, Libing Fu, Li Zhang , et al. · 2023

Hepatoblastoma with neonatal necrotizing enterocolitis: Two case reports Open

Sidou He, Xisi Wang, Chao Duan, Wen Zhao, Chiyi Jiang , et al. · 2023

We report two children with hepatoblastoma (HB) with a history of neonatal necrotizing enterocolitis (NEC). Case 1 was diagnosed with HB at 5 months of age. Liver enlargement was found during the NEC operation at 3 months of age and then w…

A transmission chain from sheep to sheep and human of zoonotic orf virus during the mpox epidemic Open

Dan Yu, Kaihu Yao, Danyu Deng, Ying Liu, Rina Wu , et al. · 2023

A case of orf virus infection in the human: Other zoonotic poxvirus infection events should not be ignored during the mpox epidemic Open

Ying Liu, Xu Li, Hongxia Yan, Yanping Zhi, Yanfei Li , et al. · 2023

Reducing the Immunogenicity of Pulchellin A-Chain, Ribosome-Inactivating Protein Type 2, by Computational Protein Engineering for Potential New Immunotoxins Open

Reza Maleki, Libing Fu, Ricardo Sobhie Diaz, Francisco Eduardo Gontijo Guimarães, Otávio Cabral-Marques , et al. · 2023

Pulchellin is a plant biotoxin categorized as a type 2 ribosome-inactivating protein (RIPs) which potentially kills cells at very low concentrations. Biotoxins serve as targeting immunotoxins (IT), consisting of antibodies conjugated to to…

Case report: Clinical features and prognosis of two Infants with rhabdomyosarcoma of the tongue Open

Peiyi Yang, Na Xu, Yan Su, Chao Duan, Shengcai Wang , et al. · 2023

Background Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, and its most common pathological types include embryonal RMS and alveolar RMS. In contrast, spindle cell RMS (SRMS) is a rare type. Moreover, the tongue is…

A transmission chain from sheep to sheep and human of zoonotic orf virus during the mpox epidemic Open

Dan Yu, Kaihu Yao, Danyu Deng, Ying Liu, Rina Wu , et al. · 2023

A transmission chain from sheep to sheep and human of zoonotic orf virus during the mpox epidemic

Compatibility Evaluation of In-Depth Profile Control Agents for Low-Permeability Fractured Reservoirs Open

Xuanran Li, Jincai Wang, Jun Ni, Libing Fu, Anzhu Xu , et al. · 2022

Under the background that the in-depth profile control technology is gradually applied in low-permeability fractured reservoirs, this paper regards block H of Changqing Oilfield as the research object, referring to the range of its physica…

Experimental Study on Profile Control of Polymer and Weak Gel Molecules in Porous Media Open

Xuanran Li, Jing Wei, Lun Zhao, Jun Ni, Libing Fu , et al. · 2022

Weak gel is a gel system formed by the mixing and crosslinking of a low-concentration polymer and a slow-release crosslinker. It can be used for profile control in deep reservoir, but its effect is greatly affected by mechanical shearing. …

Intralobar Pulmonary Sequestration Presenting as Hemothorax Secondary to Spontaneous Pneumothorax: Case Report and Literature Review Open

Tian Chen, Jie Yu, Na Zhang, Chenghao Chen, Libing Fu , et al. · 2022

Introduction Patients with pulmonary sequestration (PS), a rare congenital lung malformation, are mostly asymptomatic. Recurrent localized infection is a major complication, while sudden hemothorax is extremely rare. We present a case of i…

Malignant histiocytosis associated with mediastinal germ cell tumor: A case report Open

Peiyi Yang, Xiaoli Ma, Wen Zhao, Libing Fu, Rui Zhang , et al. · 2022

Physicians should recognize the possibility of hematologic malignancies being associated with MGCT. Suitable sites should be selected for pathological examination.

A Novel Homozygous TTC7A Missense Mutation Results in Familial Multiple Intestinal Atresia and Combined Immunodeficiency Open

Wenjun Mou, Yang Shen, Ruolan Guo, Libing Fu, Li Zhang , et al. · 2021

Rare autosomal-recessive variants in tetratricopeptide repeat domain 7A ( TTC7A ) gene have been shown to cause intestinal and immune disorders of variable severity. Missense mutations in TTC7A gene, usually retaining most of the functiona…

Clinical features and prognostic analysis of children with medulloblastoma in a single center in China Open

Yan Su, Shuai Zhu, Jing Qin, Ming Ge, Yuanqi Ji , et al. · 2021

Background: Medulloblastoma (MB) is the most common malignant pediatric brain tumor. This study systematically summarized the clinical characteristics and prognosis of children with MB in a single center in China. Methods: The clinical dat…

A Novel Germline Compound Heterozygous Mutation of BRCA2 Gene Associated With Familial Peripheral Neuroblastic Tumors in Two Siblings Open

Yeran Yang, Jiwei Chen, Hong Qin, Yaqiong Jin, Li Zhang , et al. · 2021

Objectives To investigate the genetic variants that are responsible for peripheral neuroblastic tumors (PNTs) oncogenesis in one family case. Materials and Methods One family was recruited, including the healthy parents, sister affected by…

A Novel Homozygous TTC7A Missense Mutation Results In Familial Multiple Intestinal Atresia And Combined Immunodeficiency Open

Wenjun Mou, Yang Shen, Ruolan Guo, Libing Fu, Li Zhang , et al. · 2021

Multiple intestinal atresia with combined immune deficiency (MIA-CID) are autosomal recessive disorders characterized by intestinal obstructions and profound immune defects. The study of patients with MIA and related disorders has establis…

Clinical Features, Prognosis and Susceptibility Genes of 2 Infants With Rhabdomyosarcoma of the Tongue: Case Report Open

Peiyi Yang, Na Xu, Yan Su, Chao Duan, Shengcai Wang , et al. · 2021

Background Rhabdomyosarcoma(RMS) is the most common soft tissue tumor in children. RMS of the oral cavity accounts for 10–12% of all head and neck RMS, and the tongue is a rare primary site. The most common pathological types of RMS includ…

Surgical Treatment of Loffler Endocarditis in an 8-Year-Old Girl Open

Zhangke Guo, Fan Fan, Pei Li, Xiaofeng Liu, Ning Ma , et al. · 2020

Background: Idiopathic hyper eosinophilic syndrome (HES) is a rare disease characterized by a sustained increase in eosinophilia. Heart involvement is called Loffler endocarditis. Loffler endocarditis is a serious complication of hyper eos…

Outcome of two pairs of monozygotic twins with pleuropulmonary blastoma: case report Open

Shihan Zhang, Xisi Wang, Sihui Li, Siyu Cai, Tong Yu , et al. · 2020

surgical treatment of Loffler endocarditis in an 8-year-old girl Open

Zhangke Guo, Fan Fan, Pei Li, Xiaofeng Li, Ning Ma , et al. · 2020

Introduction Idiopathic hyper eosinophilic syndrome (HES) is a rare disease characterized by sustained increase in eosinophilia. Lesions can affect various organs and systems. The global prevalence rate is unknown, and the prognosis is poo…

Systemic juvenile xanthogranuloma has a higher frequency of ALK translocations than BRAFV600E mutations Open

Jiaosheng Xu, Xin Huang, Yang Wen, Zenggang Pan, Hongyun Lian , et al. · 2020

Clinical phenotypes and genotypic characteristics of infantile-onset inflammatory bowel disease with interleukin-10 receptor A mutations in 22 Chinese children Open

Dexiu Guan, Jing Zhang, Shu Guo, Feihong Yu, Jin Zhou , et al. · 2020

Background : Infantile-onset inflammatory bowel disease (IO-IBD) patients with interleukin-10/interleukin-10 receptor (IL-10/IL-10R) mutations suffer from more severe and intractable disease. We aimed to investigate the clinical phenotypes…

Analysis of Nonlinear Seepage Characteristics of High Water Cut Preferential Channel Open

Feng-jun Hao, Libing Fu, Lun Zhao, Jun Lan · 2020

After long-term water injection, some preferential seepage channels would form which are several times or even hundreds of times larger than the original channels in the reservoir. The inefficient and ineffective circulating water injectio…

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