Libor Havlı́ček
YOU?
Author Swipe
View article: Cytokinin oxidase/dehydrogenase inhibitors: progress towards agricultural practice
Cytokinin oxidase/dehydrogenase inhibitors: progress towards agricultural practice Open
Cytokinin oxidase/dehydrogenase (CKX) inhibitors reduce the degradation of cytokinins in plants and thereby may improve the efficiency of agriculture and plant tissue culture-based practices. Here, we report a synthesis and structure–activ…
View article: Comprehensive LC-MS/MS analysis of nitrogen-related plant metabolites
Comprehensive LC-MS/MS analysis of nitrogen-related plant metabolites Open
We have developed and validated a novel LC-MS/MS method for simultaneously analyzing amino acids, biogenic amines, and their acetylated and methylated derivatives in plants. This method involves a one-step extraction of 2–5 mg of lyophiliz…
View article: Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7 Open
Targeting cyclin-dependent kinase 7 (CDK7) provides an interesting therapeutic option in cancer therapy because this kinase participates in regulating the cell cycle and transcription. Here, we describe a new trisubstituted pyrazolo[4,3-d]…
View article: Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7
Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7 Open
Targeting cyclin-dependent kinase 7 (CDK7) provides an interesting therapeutic option in cancer therapy because this kinase participates in regulating the cell cycle and transcription. Here, we describe a new trisubstituted pyrazolo[4,3- d…
View article: Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis
Sulfation of Phenolic Acids: Chemoenzymatic vs. Chemical Synthesis Open
Phenolic acids are known flavonoid metabolites, which typically undergo bioconjugation during phase II of biotransformation, forming sulfates, along with other conjugates. Sulfated derivatives of phenolic acids can be synthesized by two ap…
View article: 3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders
3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]Pyrimidine Inhibitors of Cyclin-Dependent Kinases and Cyclin K Degraders Open
3,5,7-Trisubstituted pyrazolo[4,3-d]pyrimidines have been identified as potent inhibitors of cyclin-dependent kinases (CDKs), which are established drug targets. Herein, we describe their further structural modifications leading to …
View article: Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture
Diphenylurea-derived cytokinin oxidase/dehydrogenase inhibitors for biotechnology and agriculture Open
Increasing crop productivity is our major challenge if we are to meet global needs for food, fodder and fuel. Controlling the content of the plant hormone cytokinin is a method of improving plant productivity. Cytokinin oxidase/dehydrogena…
View article: 3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models
3,5,7-Substituted Pyrazolo[4,3-<i>d</i>]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models Open
Cyclin-dependent kinases are therapeutic targets frequently deregulated in various cancers. By convenient alkylation of the 5-sulfanyl group, we synthesized 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2) H-pyrazolo[4,3- d]pyrimidines with v…
View article: Total synthesis of [ <sup>15</sup> N]-labelled C6-substituted purines from [ <sup>15</sup> N]-formamide—easy preparation of isotopically labelled cytokinins and derivatives
Total synthesis of [ <sup>15</sup> N]-labelled C6-substituted purines from [ <sup>15</sup> N]-formamide—easy preparation of isotopically labelled cytokinins and derivatives Open
Cytokinins (CKs) and their metabolites and derivatives are essential for cell division, plant growth regulation and development. They are typically found at minute concentrations in plant tissues containing very complicated biological matr…
View article: Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo[4,3‐<i>d</i>]pyrimidine scaffold
Anti‐angiogenic effects of novel cyclin‐dependent kinase inhibitors with a pyrazolo[4,3‐<i>d</i>]pyrimidine scaffold Open
Background and Purpose Cyclin‐dependent kinase 5 (CDK5) has recently emerged as an attractive target in several tumour entities. Inhibition of CDK5 has been shown to have anti‐angiogenic effects in vitro and in vivo . However, potent inhib…
View article: 5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases Open