Explanipedia

Characterization of a sesquiterpene synthase and a short-chain dehydrogenase in zerumbone biosynthesis and the applications in engineered Saccharomyces cerevisiae Open

Mengdie Xu, Ye Xia, Gao‐Li Fang, Tangli Li, Jing Ma , et al. · 2025

Introduction Zerumbone is a pharmacologically active sesquiterpenoid with limited availability. This study aims to elucidate its biosynthetic pathway in Curcuma wenyujin by identifying and characterizing the key enzymes responsible for its…

Genome-wide characterization and expression analysis of WRKY family genes in the biosynthesis of triptolide in Tripterygium wilfordii Open

Limei Tang, Xinyu Qi, Jiayu Chen, Yujun Zhao, Junhao Gu , et al. · 2025

Multiomics driven identification of glycosyltransferases in flavonoid glycoside biosynthesis in safflower Open

Nan Liu, Yu-Pan Zou, Zhouqian Jiang, Lichan Tu, Xiaoyi Wu , et al. · 2024

Spatiotemporal expression analysis of jasmonic acid and saponin‐related genes uncovers a potential biosynthetic regulation in Panax notoginseng Open

Yuru Tong, Kang Chen, Zhouqian Jiang, Lichan Tu, Yunfeng Luo , et al. · 2024

BACKGROUND Sanqi, the root of Panax notoginseng , has long been recognized for its therapeutic effects on cardiovascular diseases. Saponins, including ginsenosides and notoginsenosides, are the main bioactive components of P. notoginseng .…

Tandemly duplicated CYP82Ds catalyze 14-hydroxylation in triptolide biosynthesis and precursor production in Saccharomyces cerevisiae Open

Yifeng Zhang, Jie Gao, Lin Ma, Lichan Tu, Tianyuan Hu , et al. · 2023

Triptolide is a valuable multipotent antitumor diterpenoid in Tripterygium wilfordii , and its C-14 hydroxyl group is often selected for modification to enhance both the bioavailability and antitumor efficacy. However, the mechanism for 14…

Genome‐wide analysis of MYB family genes in Tripterygium wilfordii and their potential roles in terpenoid biosynthesis Open

Meng Xia, Lichan Tu, Yuan Liu, Zhouqian Jiang, Xiaoyi Wu , et al. · 2022

Terpenoids are a class of significant bioactive components in the woody vine of Tripterygium wilfordii . Previous studies have shown that MYB transcription factors play important roles in plant secondary metabolism, growth, and development…

Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii Open

Lichan Tu, Xin-Bo Cai, Yifeng Zhang, Yuru Tong, Jian Wang , et al. · 2022

Probing the functions of friedelane‐type triterpene cyclases from four celastrol‐producing plants Open

Yun Lü, Yunfeng Luo, Jiawei Zhou, Tianyuan Hu, Lichan Tu , et al. · 2021

SUMMARY Triterpenes are among the most diverse plant natural products, and their diversity is closely related to various triterpene skeletons catalyzed by different 2,3‐oxidosqualene cyclases (OSCs). Celastrol, a friedelane‐type triterpene…

Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol Open

Jiawei Zhou, Tianyuan Hu, Yuan Liu, Lichan Tu, Yadi Song , et al. · 2021

Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis Open

Lichan Tu, Ping Su, Zhongren Zhang, Linhui Gao, Jiadian Wang , et al. · 2020

The chromosome-level reference genome assembly for Panax notoginseng and insights into ginsenoside biosynthesis Open

Zhouqian Jiang, Lichan Tu, Weifei Yang, Yifeng Zhang, Tianyuan Hu , et al. · 2020

Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis Open

Lichan Tu, Ping Su, Zhongren Zhang, Linhui Gao, Jiadian Wang , et al. · 2020

A novel strategy to enhance terpenoids production using cambial meristematic cells of Tripterygium wilfordii Hook. f. Open

Yadi Song, Shang Chen, Xiujuan Wang, Rui Zhang, Lichan Tu , et al. · 2019

Background Tripterygium wilfordii Hook. f. ( T. wilfordii ) is an important medicinal plant with anti-inflammatory, immunosuppressive and anti-tumor activities. The main bioactive ingredients are diterpenoids and triterpenoids, such as tri…

Friedelane‐type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast Open

Jiawei Zhou, Tianyuan Hu, Linhui Gao, Ping Su, Yifeng Zhang , et al. · 2019

Summary Celastrol is a promising bioactive compound isolated from Tripterygium wilfordii and has been shown to possess many encouraging preclinical applications. However, the celastrol biosynthetic pathway is poorly understood, especially …

Cloning and expression analysis of two dehydrodolichyl diphosphate synthase genes from Tripterygium wilfordii Open

Wei Gao, Luqi Huang, Linhui Gao, Ping Su, Yifeng Zhang , et al. · 2018

Objective: To clone and investigate two dehydrodolichyl diphosphate synthase genes of Tripterygium wilfordii by bioinformatics and tissue expression analysis. Materials and Methods: According to the T. wifordii transcriptome database, spec…

Probing the Single Key Amino Acid Responsible for the Novel Catalytic Function of ent-Kaurene Oxidase Supported by NADPH-Cytochrome P450 Reductases in Tripterygium wilfordii Open

Ping Su, Hongyu Guan, Yifeng Zhang, Xing Wang, Linhui Gao , et al. · 2017

Tripterygium wilfordii produces not only ent-kaurene, which is an intermediate of gibberellin (GA) biosynthesis in flowering plants, but also 16α-hydroxy-ent-kaurane, whose physiological role has not been characterized…

Lichan Tu YOU? Author Swipe