Lichan Wang
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View article: Comparison of TLR4 Genotype and TLR4 Pathway-Related Cytokines in Different Strains of Mice in Response to Pertussis Toxin Challenge
Comparison of TLR4 Genotype and TLR4 Pathway-Related Cytokines in Different Strains of Mice in Response to Pertussis Toxin Challenge Open
Background: The genetic background of Toll-like receptor 4 (TLR4) proved to be important in the induction of immune protection against Bordetella pertussis infection in humans. Currently, the evaluation of the acellular pertussis (aP) vacc…
View article: Evaluation of acellular pertussis vaccine: comparisons among different strains of mice
Evaluation of acellular pertussis vaccine: comparisons among different strains of mice Open
The current study was designed to comparatively analyse the reactions of different mouse strains in response to acellular pertussis (aP) vaccine, with attempt to further provide a reference for aP vaccine evaluation. NIH mice, ICR mice, an…
View article: An Image Encryption Algorithm Based on the Improved Sine-Tent Map
An Image Encryption Algorithm Based on the Improved Sine-Tent Map Open
This paper makes use of the characteristics of initial sensitivity and randomness of the chaotic map to design an image encryption algorithm based on the sine map and the tent map. The sine map is used to improve the tent map; then, the im…
View article: Infant Rhesus Macaques as a Nonhuman Primate Model of Bordetella Pertussis
Infant Rhesus Macaques as a Nonhuman Primate Model of Bordetella Pertussis Open
Background: The prevalent resurgence of pertussis recently creates a vital public health problem worldwide. To understand the pertussis pathogenesis and host response to both pathogen and vaccine, a suitable pertussis animal model, particu…
View article: A preliminary study on the application of PspA as a carrier for group A meningococcal polysaccharide
A preliminary study on the application of PspA as a carrier for group A meningococcal polysaccharide Open
This study aimed to explore the feasibility of pneumococcal surface protein A (PspA) as a carrier protein. Three recombinant pneumococcal surface proteins from three different clades were expressed by the prokaryotic expression system and …
View article: Experimental infection characteristics of<i>Bordetella</i>pertussis via aerosol challenge on rhesus macaques
Experimental infection characteristics of<i>Bordetella</i>pertussis via aerosol challenge on rhesus macaques Open
The effect of aerosol challenge of rhesus macaques with Bordetella pertussis and the feasibility of using rhesus monkeys as an animal model for pertussis infection were evaluated in this study. Four 1-year old rhesus macaques were aerosol …
View article: An Analysis Of Theoretical And Empirical Stidies On Metadiscourse
An Analysis Of Theoretical And Empirical Stidies On Metadiscourse Open
Metadiscourse refers to the method in organizing discourse, expressing the writer’s attitudes towards the texts and readers. It has been studied by many scholars in discourse analysis in recent years. This article reviewed previous studies…
View article: AN ANALYSIS OF THEORETICAL AND EMPIRICAL STIDIES ON METADISCOURSE
AN ANALYSIS OF THEORETICAL AND EMPIRICAL STIDIES ON METADISCOURSE Open
Metadiscourse refers to the method in organizing discourse, expressing the writer’s attitudes towards the texts and readers. It has been studied by many scholars in discourse analysis in recent years. This article reviewed previous studies…
View article: Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis
Whole-genome sequencing reveals the effect of vaccination on the evolution of Bordetella pertussis Open
Herd immunity can potentially induce a change of circulating viruses. However, it remains largely unknown that how bacterial pathogens adapt to vaccination. In this study, Bordetella pertussis , the causative agent of whooping cough, was s…