Li-Chong Wang
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View article: 73 Spatial detection reveals T-cell activation and exhaustion states in the tumor microenvironment
73 Spatial detection reveals T-cell activation and exhaustion states in the tumor microenvironment Open
View article: 87 Evaluating anti-PD-L1 treatment response in bladder cancer patients by spatially detecting PD-1/PD-L1 interaction, protein and mRNA
87 Evaluating anti-PD-L1 treatment response in bladder cancer patients by spatially detecting PD-1/PD-L1 interaction, protein and mRNA Open
View article: 81 Multiomic mapping of the brain: same-section, fully-automated spatial RNA and protein detection on mouse frozen tissues
81 Multiomic mapping of the brain: same-section, fully-automated spatial RNA and protein detection on mouse frozen tissues Open
View article: 69 A novel protease-free method for the co-detection of RNA and protein biomarkers using the RNAscope™ technology
69 A novel protease-free method for the co-detection of RNA and protein biomarkers using the RNAscope™ technology Open
Background Spatial biology methods are increasingly used for the characterization of complex tissue microenvironments, the understanding of which can shed light on fundamental biological mechanisms and better inform development of targeted…
View article: 79 Multiplexed detection of RNA and protein to interrogate the tumor-immune landscape with a novel automated RNAscope™ assay
79 Multiplexed detection of RNA and protein to interrogate the tumor-immune landscape with a novel automated RNAscope™ assay Open
Background Studying cell-cell interactions can have important implications in immuno-oncology, inflammation, and neuroscience. Tissue heterogeneity poses immense challenges to understanding underlying molecular mechanisms using techniques …
View article: 71 Integration of RNA in situ hybridization and sequential immunofluorescence for same-slide fully automated multi-omics analysis of the tumor microenvironment
71 Integration of RNA in situ hybridization and sequential immunofluorescence for same-slide fully automated multi-omics analysis of the tumor microenvironment Open
Background Spatial biology has transformed our understanding of the tumor microenvironment (TME) by enabling the study of tissue composition and intercellular interactions at a single-cell level while preserving spatial context.1–3
View article: 96 Visualization of protein-protein interactions in the tumor immune microenvironment with a high spatial resolution analysis
96 Visualization of protein-protein interactions in the tumor immune microenvironment with a high spatial resolution analysis Open
Background Tumor cells employ multiple tactics to evade immune cell activities. Programmed cell death ligand 1 (PD-L1) is one of the key antigens presented on tumor cells that bind to programmed cell death protein 1 (PD-1) and block immune…
View article: Case Report: Successful Use of BRAF/MEK Inhibitors in Aggressive BRAF-mutant Craniopharyngioma
Case Report: Successful Use of BRAF/MEK Inhibitors in Aggressive BRAF-mutant Craniopharyngioma Open
Under specific conditions, individuals diagnosed with PCP can attain a complete tumor response following combined treatment with BRAFi/MEKi.
View article: Multiplexed RNA-protein co-detection to explore tumor-immune landscape using a novel automated RNAscope&[trade] assay
Multiplexed RNA-protein co-detection to explore tumor-immune landscape using a novel automated RNAscope&[trade] assay Open
Development of next-generation immunotherapies need a highly sensitive multiomics platform to evaluate diagnostic and therapeutic biomarkers. Tissue heterogeneity poses immense challenges to understanding underlying molecular mechanisms us…
View article: Gypenosides Inhibit Glioma Growth by Regulating Apoptosis and Autophagy Through Network Pharmacology Analysis
Gypenosides Inhibit Glioma Growth by Regulating Apoptosis and Autophagy Through Network Pharmacology Analysis Open
View article: The safety and effectiveness of salvianolate in preventing perioperative venous thromboembolism in China
The safety and effectiveness of salvianolate in preventing perioperative venous thromboembolism in China Open
Background: Salvianolate, a common drug for stabilizing heart disease and Angina Pectoris, is considered to be off-label for preventing venous thromboembolism (VTE) or anticoagulation at present. However, many clinical studies have showed …
View article: Additional file 1 of Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma
Additional file 1 of Construction of a competitive endogenous RNA network and analysis of potential regulatory axis targets in glioblastoma Open
Additional file 1. In vitro experiment
View article: Knockdown lncRNA DLEU1 Inhibits Gliomas Progression and Promotes Temozolomide Chemosensitivity by Regulating Autophagy
Knockdown lncRNA DLEU1 Inhibits Gliomas Progression and Promotes Temozolomide Chemosensitivity by Regulating Autophagy Open
Gliomas are the most fatal malignant cerebral tumors. Temozolomide (TMZ), as the primary chemotherapy drug, has been widely used in clinics. However, resistance of TMZ still remains to poor defined. LncRNAs have been reported to play cruci…
View article: M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme
M6A RNA Methylation Regulator HNRNPC Contributes to Tumorigenesis and Predicts Prognosis in Glioblastoma Multiforme Open
Glioblastoma multiforme (GBM) is the most malignant glioma with a high death rate. N6-methyladenosine (m6A) RNA methylation plays an increasingly important role in tumors. The current study aimed to determine the function of the regulators…