Explanipedia

The effects of submicron‐textured surface topography on antibiotic efficacy against biofilms Open

Asma Khursheed, Li‐Chong Xu, Christopher A. Siedlecki · 2024

Submicron‐textured surfaces have been a promising approach to mitigate biofilm development and control microbial infection. However, the use of the single surface texturing approach is still far from ideal for achieving complete control of…

In vivo assessment of dual-function submicron textured nitric oxide releasing catheters in a 7-day rabbit model Open

Yi Wu, Li‐Chong Xu, Eric Yeager, Keren G. Beita, Natalie Crutchfield , et al. · 2024

FXII contact activation products have an inhibitory effect on αFXIIa Open

Li‐Chong Xu, Christopher A. Siedlecki · 2023

It is accepted that the contact activation complex of the intrinsic pathway of blood coagulation cascade produces active enzymes that lead to plasma coagulation following biomaterial contact. In this study, FXII was activated through conta…

In vitro evaluation of blood plasma coagulation responses to four medical-grade polyurethane polymers Open

Lan Huong Nguyen, Li‐Chong Xu, Eric Yeager, Jason Weiss, Christopher A. Siedlecki · 2023

Segmented polyurethane (PU) block copolymers are widely used in implantable cardiovascular medical devices due to their good biocompatibility and excellent mechanical properties. More specifically, PU Biospan MS/0.4 was used in ventricular…

Surfaces modified with small molecules that interfere with nucleotide signaling reduce Staphylococcus epidermidis biofilm and increase the efficacy of ciprofloxacin Open

Li‐Chong Xu, Alyssa Ochetto, Chen Chen, Dongxiao Sun, Harry R. Allcock , et al. · 2023

Nucleotide Messenger Signaling of Staphylococci in Responding to Nitric Oxide – Releasing Biomaterials Open

Alyssa Ochetto, Dongxiao Sun, Christopher A. Siedlecki, Li‐Chong Xu · 2023

Nitric oxide (NO) releasing biomaterials are a promising approach against medical device associated microbial infection. In contrast to the bacteria-killing effects of NO at high concentrations, NO at low concentrations serves as an import…

Crosslinkable fluorophenoxy‐substituted poly[bis(octafluoropentoxy) phosphazene] biomaterials with improved antimicrobial effect and hemocompatibility Open

Shelby Alwine, Chen Chen, Lihui Shen, Harry R. Allcock, Christopher A. Siedlecki , et al. · 2023

Biomaterial‐associated microbial infection is one of the most frequent and severe complications associated with the use of biomaterials in medical devices. In previous studies, we developed new fluorinated polyphosphazenes, poly[bis(octafl…

Kinetic and Dynamic Effects on Degradation of von Willebrand Factor Open

Choon‐Sik Jhun, Li‐Chong Xu, Christopher A. Siedlecki, Carlo Bartoli, Eric Yeager , et al. · 2022

The loss of high molecular weight multimers (HMWM) of von Willebrand factor (vWF) in aortic stenosis (AS) and continuous-flow left ventricular assist devices (cf-LVADs) is believed to be associated with high turbulent blood shear. The obje…

Surface texturing and combinatorial approaches to improve biocompatibility of implanted biomaterials Open

Li‐Chong Xu, Christopher A. Siedlecki · 2022

Biomaterial associated microbial infection and blood thrombosis are two of the barriers that inhibit the successful use of implantable medical devices in modern healthcare. Modification of surface topography is a promising approach to comb…

Submicron topography design for controlling staphylococcal bacterial adhesion and biofilm formation Open

Li‐Chong Xu, Christopher A. Siedlecki · 2022

Surface topography modification with nano‐ or micro‐textured structures has been an efficient approach to inhibit microbial adhesion and biofilm formation and thereby to prevent biomaterial‐associated infection without modification of surf…

Controlling Biomaterial Associated Infections with Small Molecules that Interfere with Nucleotide Second Messenger Signaling Open

Li‐Chong Xu, Alyssa Ochetto, Chen Chen, Dongxiao Sun, Harry R. Allcock , et al. · 2022

Issue Information Open

Jeremy Gilbert, Danielle S. W. Benoit, Sepanta Fazaeli, Fereshteh Mirahmadi, Vincent Everts , et al. · 2020

Part B: Applied Biomaterials is a highly interdisciplinary peerreviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterials…

Inhibition of bacterial adhesion and biofilm formation by a textured fluorinated alkoxyphosphazene surface Open

Meixian Tang, Chen Chen, Jieru Zhu, Harry R. Allcock, Christopher A. Siedlecki , et al. · 2020

New cross‐linkable poly[bis(octafluoropentoxy) phosphazene] biomaterials: Synthesis, surface characterization, bacterial adhesion, and plasma coagulation responses Open

Li‐Chong Xu, Chen Chen, Jieru Zhu, Meixian Tang, Andy Chen , et al. · 2020

Biomaterial‐associated microbial infection and thrombosis represent major issues to the success of long‐term use of implantable blood‐contacting medical devices. The development of new poly[bis(octafluoropentoxy) phosphazene (OFP) biomater…

Increased circulating microparticles in streptozotocin‐induced diabetes propagate inflammation contributing to microvascular dysfunction Open

Qilong Feng, Christian J. Stork, Sulei Xu, Dong Yuan, Xinghai Xia , et al. · 2018

Key points Circulating microparticles (MPs) are elevated in many cardiovascular diseases and have been considered as biomarkers of disease prognosis; however, current knowledge of MP functions has been mainly derived from in vitro studies …

Liquid Biopsy of Vitreous Reveals an Abundant Vesicle Population Consistent With the Size and Morphology of Exosomes Open

Yuanjun Zhao, Sarah R. Weber, Joshua Lease, Mariano Russo, Christopher A. Siedlecki , et al. · 2018

The identification of vitreous exosomes lays the groundwork for a transformed understanding of pathophysiology and treatment mechanisms in retinal disease, and further validates the use of vitreous as a proximal biofluid of the retina.

Surface dependent contact activation of factor XII and blood plasma coagulation induced by mixed thiol surfaces Open

James W. Bauer, Li‐Chong Xu, Erwin A. Vogler, Christopher A. Siedlecki · 2017

Studies of the activation of FXII in both platelet poor plasma and in neat buffer solutions were undertaken for a series of mixed thiol self-assembled monolayers spanning a broad range of water wettability. A wide spectrum of carboxyl/meth…

Antimicrobial nitric oxide releasing surfaces based on S-nitroso-N-acetylpenicillamine impregnated polymers combined with submicron-textured surface topography Open

Yaqi Wo, Li‐Chong Xu, Li Zi, Adam J. Matzger, Mark E. Meyerhoff , et al. · 2017

SNAP-impregnated textured polymer films having up to 38 day NO-release were shown to have synergistic effects in inhibiting bacterial adhesion.

Issue Information Open

Jeremy L. Gilbert, Joel D. Bumgardner, Elizabeth Cosgriff‐Hernandez, Jean T. Jacob, Allison M Ostdiek , et al. · 2016

Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterial…

TMIC-01TUMOR TARGETED QUANTUM DOTS TO IDENTIFY GLIOMA INITIATING CELLS AND EXOSOMES Open

A.B. Madhankumar, Oliver Mrowczynski, Suhag Patel, Elias Rizk, Cody Weston , et al. · 2015

TUMOR MICROENVIRONMENT TMIC-01. TUMOR TARGETED QUANTUM DOTS TO IDENTIFY GLIOMA INITIATING CELLS AND EXOSOMES Achutha Madhankumar, Oliver Mrowczynski, Suhag Patel, Elias Rizk, Cody Weston, Michael Glantz, Lichong Xu, Christopher Siedlecki, …

The role of substrate topography on the cellular uptake of nanoparticles Open

Changjin Huang, Tuğba Özdemir, Li‐Chong Xu, Peter E. M. Butler, Christopher A. Siedlecki , et al. · 2015

Improving targeting efficacy has been a central focus of the studies on nanoparticle (NP)‐based drug delivery nanocarriers over the past decades. As cells actively sense and respond to the local physical environments, not only the NP desig…

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