Lidan Zhang
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View article: miRNA-125b-5p-rich exosomes derived from fibro-adipogenic progenitors promoting muscle regeneration through inducing pro-regenerative macrophages
miRNA-125b-5p-rich exosomes derived from fibro-adipogenic progenitors promoting muscle regeneration through inducing pro-regenerative macrophages Open
View article: The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation
The EZH2 selective inhibitor ZLD1039 attenuates UUO-induced renal fibrosis by suppressing YAP activation Open
View article: pSOFA score serves as predicting the severity and outcome of sepsis in critically ill children
pSOFA score serves as predicting the severity and outcome of sepsis in critically ill children Open
To investigate the prognostic value of the Pediatric Sequential Organ Failure Assessment (pSOFA) in children with sepsis during hospitalization. Clinical data for children with sepsis or severe sepsis hospitalized in the PICU of the First …
View article: Retrospective Analysis of Glucocorticoid Therapy in Pediatric immunoglobulin A Nephropathy: Kidney Outcomes and Efficacy
Retrospective Analysis of Glucocorticoid Therapy in Pediatric immunoglobulin A Nephropathy: Kidney Outcomes and Efficacy Open
Background: The efficacy of glucocorticoid (GC) in the management of immunoglobulin A nephropathy (IgAN) remains highly controversial. The study was conducted to analyze the efficacy and kidney outcomes of GC in the treatment of pediatric …
View article: Compound heterozygous variants of the NARS2 gene in siblings with refractory seizures: two case report and literature review
Compound heterozygous variants of the NARS2 gene in siblings with refractory seizures: two case report and literature review Open
Background Biallelic variants in NARS2 that encodes the mitochondrial asparaginyl-tRNA synthetase are associated with a wide spectrum of clinical phenotypes. Herein, we report on two siblings carrying the same compound heterozygous missens…
View article: Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023
Epidemiology and Mortality Risk of Severe Viral Pneumonia During the Pre-Pandemic, COVID-19 Pandemic and Post-Pandemic Era: A Retrospective Study of Hospitalized Children in ShenZhen, China Between 2017 and 2023 Open
The COVID-19 pandemic has altered the landscape of respiratory viruses causing SVP in children. The presence of underlying health conditions, particularly acute leukemia, other malignancies, and immunodeficiency, significantly increases th…
View article: Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients Open
Clinical manifestations of DRESS are complex. Facial edema, extensive skin involvement, and atypical lymphocytes have emerged as significant diagnostic indicators.
View article: Integrating Production-Oriented Approach (POA) in Flipped Classrooms: An Action Research on Enhancing Spoken English Instruction for English Majors in China
Integrating Production-Oriented Approach (POA) in Flipped Classrooms: An Action Research on Enhancing Spoken English Instruction for English Majors in China Open
This study addresses the limitations of traditional English-speaking instruction for English majors in China, such as limited class time, insufficient opportunities for classroom speaking, and inadequate support for autonomous learning. In…
View article: Gamification in Mobile Applications: The Regulation of Children’s Course Games by Commensurability Education System
Gamification in Mobile Applications: The Regulation of Children’s Course Games by Commensurability Education System Open
The nation’s education-related information reform is making slow progress in light of the recent significant advancements in information technology. Early childhood education informatization has become a crucial part of the national educat…
View article: Impact of early caffeine administration on respiratory outcomes in very preterm infants initially receiving invasive mechanical ventilation
Impact of early caffeine administration on respiratory outcomes in very preterm infants initially receiving invasive mechanical ventilation Open
Objective The guidelines recommend early caffeine administration for preterm infants requiring non-invasive mechanical ventilation since earlier treatment is associated with better outcomes. The objective was to evaluate the impact of earl…
View article: Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level
Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level Open
View article: Comprehensive analysis of the ability of the Cuproptosis- related gene signature to predict the prognosis of patients with pediatric acute myeloid leukemia
Comprehensive analysis of the ability of the Cuproptosis- related gene signature to predict the prognosis of patients with pediatric acute myeloid leukemia Open
Background: Cuproptosis is a new type of Regulated Cell Death (RCD) that is distinct from other known types of cell death, and novel prognostic models for leukemia have been proposed based on this process. However, most studies have been p…
View article: Correction to: Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency
Correction to: Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency Open
View article: Expression of CREBBP and EP300 Associated With Tumor Volume in Patients With Grade-3 Glioma: A Retrospective Analysis
Expression of CREBBP and EP300 Associated With Tumor Volume in Patients With Grade-3 Glioma: A Retrospective Analysis Open
Background: Reliable predictive data are crucial for making accurate treatment decisions in glioma patients, but it can be challenging to obtain due to limited information in many cases. Numerous research studies have indicated the involve…
View article: Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency
Clinical and molecular characterization of 10 Chinese children with congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency Open
Background The clinical manifestations of nonclassical 11beta-hydroxylase deficiency are very similar to those of non-classical 21-hydroxylase deficiency. For this study, we investigated the relationship between the clinical and molecular …
View article: Construction of Different Oil Phases-Based Nanoemulsion Delivery Platform and Biodistribution Evaluation on Inflammatory Cells and Animal Models
Construction of Different Oil Phases-Based Nanoemulsion Delivery Platform and Biodistribution Evaluation on Inflammatory Cells and Animal Models Open
Inflammation is the response of the immune system to infection and injury, with complex interactions with the body, tissues and cells, and plays an important role in the initiation and progression of many diseases such as cancer and cardio…
View article: A novel VEGFR inhibitor ZLF-095 with potent antitumor activity and low toxicity
A novel VEGFR inhibitor ZLF-095 with potent antitumor activity and low toxicity Open
View article: Design, Synthesis, and Biological Evaluation of a Potent Dual EZH2–BRD4 Inhibitor for the Treatment of Some Solid Tumors
Design, Synthesis, and Biological Evaluation of a Potent Dual EZH2–BRD4 Inhibitor for the Treatment of Some Solid Tumors Open
Enhancer of zeste homolog 2 (EZH2) mediates the trimethylation of histone 3 lysine 27 (H3K27) to promote gene silencing. Inhibition of EZH2 is a viable strategy for cancer treatment; however, only a small subset of hematological malignanci…
View article: Transcription analyses of differentially expressed mRNAs, lncRNAs, circRNAs, and miRNAs in the growth plate of rats with glucocorticoid-induced growth retardation
Transcription analyses of differentially expressed mRNAs, lncRNAs, circRNAs, and miRNAs in the growth plate of rats with glucocorticoid-induced growth retardation Open
Background Glucocorticoids (GCs) are commonly used to treat autoimmune diseases and malignancies in children and adolescents. Growth retardation is a common adverse effect of GC treatment in pediatric patients. Accumulating evidence indica…
View article: Abnormal umbilical cord insertion and birth weight discordancy in monochorionic diamniotic twins: A retrospective study
Abnormal umbilical cord insertion and birth weight discordancy in monochorionic diamniotic twins: A retrospective study Open
To investigate the relationship between abnormal umbilical cord insertion and birthweight discordance in monochorionic diamnionic (MCDA) twins. A total of 137 pairs of MCDAs were retrospectively analyzed who delivered and survived in Hangz…
View article: Clinical characteristics of a male child with non-classic lipoid congenital adrenal hyperplasia and literature review
Clinical characteristics of a male child with non-classic lipoid congenital adrenal hyperplasia and literature review Open
Background Lipoid congenital adrenal hyperplasia (LCAH) is a rare and severe disorder that is caused by mutations in the steroidogenic acute regulatory protein (StAR). Non-classic LCAH is defined as late-onset glucocorticoid deficiency and…
View article: Retrospective analysis and literature review of four cases of thyroid hormone resistance syndrome caused by THRB gene mutation
Retrospective analysis and literature review of four cases of thyroid hormone resistance syndrome caused by THRB gene mutation Open
The clinical manifestations of pediatric RTH syndrome vary, and the diagnosis mainly depends on thyroid function tests. Heterozygous mutations in THRB are overall rare, even if with the advanced development of next-generation sequencing, n…
View article: Circulating circular RNA profiles associated with celiac disease seropositivity in children with type 1 diabetes
Circulating circular RNA profiles associated with celiac disease seropositivity in children with type 1 diabetes Open
Introduction The frequency of celiac disease autoantibody (CDAb) positivity in type 1 diabetes (T1D) has increased due to unclear mechanisms, including autoimmune injury. Circular ribonucleic acids (circRNAs) participate in autoimmune dise…
View article: Author Correction: Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma
Author Correction: Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma Open
View article: Effectiveness of Sodium Bicarbonate Infusion on Mortality in Critically Ill Children With Metabolic Acidosis
Effectiveness of Sodium Bicarbonate Infusion on Mortality in Critically Ill Children With Metabolic Acidosis Open
Objective: Metabolic acidosis often occurs in the paediatric intensive care unit (PICU). Although sodium bicarbonate (SB) has been widely used in paediatrics, data on the effect of SB on children with metabolic acidosis in the PICU are sca…
View article: Green construction and release mechanism of lignin-based double-layer coated urea
Green construction and release mechanism of lignin-based double-layer coated urea Open
Background: Currently, there are few reports about the sustained-release time of single-layer non-modified lignin-based coated urea that meets the sustained-release standard. Therefore, the unmodified lignin-based material by adding a hydr…
View article: Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway
Selective EZH2 inhibitor zld1039 alleviates inflammation in cisplatin-induced acute kidney injury partially by enhancing RKIP and suppressing NF-κB p65 pathway Open
View article: Xuesaitong oral preparation as adjuvant therapy for treating acute cerebral infarction: A systematic review and meta-analysis of randomized controlled trials
Xuesaitong oral preparation as adjuvant therapy for treating acute cerebral infarction: A systematic review and meta-analysis of randomized controlled trials Open
XSTOP plus CT is conditional recommended to improve the total effective rate, NIHSS score, PV, CSS score, and no serious adverse reactions were noted. The GRADE assessment indicates that the overall certainty quality of evidence is very lo…
View article: All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease
All roads lead to Rome — a review of the potential mechanisms by which exerkines exhibit neuroprotective effects in Alzheimer’s disease Open
Age-related neurodegenerative disorders such as Alzheimer's disease (AD) have become a critical public health issue due to the significantly extended human lifespan, leading to considerable economic and social burdens. Traditional therapie…
View article: An Advanced SAR Image Despeckling Method by Bernoulli-Sampling-Based Self-Supervised Deep Learning
An Advanced SAR Image Despeckling Method by Bernoulli-Sampling-Based Self-Supervised Deep Learning Open
As one of the main sources of remote sensing big data, synthetic aperture radar (SAR) can provide all-day and all-weather Earth image acquisition. However, speckle noise in SAR images brings a notable limitation for its big data applicatio…