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View article: Equivalence of freeze-dried and liquid-frozen formulations of MVA-BN as smallpox and mpox vaccine
Equivalence of freeze-dried and liquid-frozen formulations of MVA-BN as smallpox and mpox vaccine Open
Modified Vaccinia Ankara Bavarian Nordic (MVA-BN) as a smallpox and mpox vaccine has been approved in its liquid-frozen (LF) formulation in the US, Canada, and EU. A freeze-dried (FD) formulation may offer additional benefits, such as a lo…
View article: A multivalent RSV vaccine based on the Modified Vaccinia Ankara vector shows moderate protection against disease caused by RSV in older adults in a Phase 3 clinical study
A multivalent RSV vaccine based on the Modified Vaccinia Ankara vector shows moderate protection against disease caused by RSV in older adults in a Phase 3 clinical study Open
Respiratory syncytial virus (RSV) causes a significant disease burden in older adults. The live recombinant vaccine based on a nonreplicating modified vaccinia Ankara (MVA-BN) poxvirus, MVA-BN-RSV, encoding for multiple proteins of RSV sub…
View article: Equivalence of Freeze-dried and Liquid-frozen Formulations of MVA-BN as Smallpox and Mpox Vaccine
Equivalence of Freeze-dried and Liquid-frozen Formulations of MVA-BN as Smallpox and Mpox Vaccine Open
Orthopox virus-induced diseases such as smallpox and mpox (also known as monkeypox previously) remain a serious public health concern. Modified Vaccinia Ankara Bavarian Nordic (MVA-BN) has been approved in its liquid-frozen (LF) formulatio…
View article: One- and Two-Dose Vaccinations With Modified Vaccinia Ankara-Bavarian Nordic Induce Durable B-Cell Memory Responses Comparable to Replicating Smallpox Vaccines
One- and Two-Dose Vaccinations With Modified Vaccinia Ankara-Bavarian Nordic Induce Durable B-Cell Memory Responses Comparable to Replicating Smallpox Vaccines Open
Background Although modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccination is approved for smallpox and monkeypox prevention, immunological persistence and booster effects remain undescribed. Methods Participants naive to smallpox v…
View article: Single and 2-dose vaccinations with MVA-BN<sup>®</sup> induce durable B cell memory responses in healthy volunteers that are comparable to older generation replicating smallpox vaccines
Single and 2-dose vaccinations with MVA-BN<sup>®</sup> induce durable B cell memory responses in healthy volunteers that are comparable to older generation replicating smallpox vaccines Open
While the MVA-BN vaccine has been proven protective against smallpox and monkeypox, the long-term immunological persistence or booster effect has not been described. In this set of clinical studies, participants who had never been immunize…
View article: The changing epidemiology of human monkeypox—A potential threat? A systematic review
The changing epidemiology of human monkeypox—A potential threat? A systematic review Open
Monkeypox, a zoonotic disease caused by an orthopoxvirus, results in a smallpox-like disease in humans. Since monkeypox in humans was initially diagnosed in 1970 in the Democratic Republic of the Congo (DRC), it has spread to other regions…
View article: The changing epidemiology of human monkeypox – a potential threat? A systematic review
The changing epidemiology of human monkeypox – a potential threat? A systematic review Open
Monkeypox, a zoonotic disease caused by an orthopoxvirus, results in a smallpox-like disease in humans. Since monkeypox in humans was initially diagnosed in 1970 in the Democratic Republic of the Congo (DRC), it has spread to other regions…
View article: Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer
Phase III Trial of PROSTVAC in Asymptomatic or Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer Open
PURPOSE PROSTVAC, a viral vector–based immunotherapy, prolonged median overall survival (OS) by 8.5 months versus placebo in metastatic castration-resistant prostate cancer in a phase II study. This phase III study further investigated tho…