Li‐Di Xu
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View article: The role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer: biomarker analyses from a prospective phase II trial
The role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer: biomarker analyses from a prospective phase II trial Open
View article: First validation of the Prostatype® P‐score in an Asian cohort: Improving risk stratification for prostate cancer
First validation of the Prostatype® P‐score in an Asian cohort: Improving risk stratification for prostate cancer Open
Objectives To evaluate the prognostic performance of the Prostatype® score (P‐score) in the Asian prostate cancer (PCa) cohort and to assess its ability to refine risk stratification compared to the National Comprehensive Cancer Network (N…
View article: Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma
Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma Open
Introduction: Early-stage poorly differentiated lung adenocarcinoma (LUAD) is plagued by a high risk of postoperative recurrence, and its prognostic heterogeneity complicates treatment and surveillance planning. We conducted this integrati…
View article: Efficacy of neoadjuvant toripalimab plus chemotherapy and the role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer (RENAISSANCE study): a prospective phase II trial
Efficacy of neoadjuvant toripalimab plus chemotherapy and the role of dynamic monitoring of plasma cell-free DNA methylation in predicting pathological response in resectable stage IIB-IIIB non-small cell lung cancer (RENAISSANCE study): a prospective phase II trial Open
Introduction: Neoadjuvant chemoimmunotherapy does not benefit all non-small cell lung cancer (NSCLC) patients, and reliable biomarkers are urgently needed. We conducted this prospective phase II trial of neoadjuvant chemoimmunotherapy to e…
View article: Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study
Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study Open
Background Commonly used noninvasive serological indicators serve as a step before endoscope diagnosis and help identify the high-risk gastric cancer (GC) population. However, they are associated with high false positives and high false ne…
View article: Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study (Preprint)
Multidimensional Analysis of a Cell-Free DNA Whole Methylome Sequencing Assay for Early Detection of Gastric Cancer: Protocol for an Observational Case-Control Study (Preprint) Open
BACKGROUND Commonly used noninvasive serological indicators serve as a step before endoscope diagnosis and help identify the high-risk gastric cancer (GC) population. However, they are associated with high false positives and high false n…
View article: Development and validation of a blood-based assay for gastric cancer early detection: A multidimensional analysis of cell-free DNA whole methylome sequencing—protocol for an observational, case‒control study
Development and validation of a blood-based assay for gastric cancer early detection: A multidimensional analysis of cell-free DNA whole methylome sequencing—protocol for an observational, case‒control study Open
Background Cancer-related features in cell-free DNA (cfDNA) fragments have gradually been identified and play essential roles in noninvasive early cancer detection. Integrated analysis of several cfDNA features has enhanced detection sensi…
View article: P‐score in preoperative biopsies accurately predicts P‐score in final pathology at radical prostatectomy in patients with localized prostate cancer
P‐score in preoperative biopsies accurately predicts P‐score in final pathology at radical prostatectomy in patients with localized prostate cancer Open
Background Prostate cancer (PCa) is a highly heterogeneous, multifocal disease, and identification of clinically significant lesions is challenging, which complicates the choice of adequate treatment. The Prostatype® score (P‐score) is int…
View article: Correction to: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s
Correction to: Wig-1 regulates cell cycle arrest and cell death through the p53 targets FAS and 14-3-3s Open
View article: A Novel Risk Score (P-score) Based on a Three-Gene Signature, for Estimating the Risk of Prostate Cancer-Specific Mortality
A Novel Risk Score (P-score) Based on a Three-Gene Signature, for Estimating the Risk of Prostate Cancer-Specific Mortality Open
We developed the P-score, a risk stratification system for newly diagnosed PCa patients by integrating a three-gene signature measured in CNB tissue. The P-score could provide valuable decision support to distinguish PCa patients with favo…
View article: MP11-17 P-SCORE BASED ON THREE EMBRYONIC STEM CELL GENES IMPROVES PROGNOSTIC EVALUATION FOR METASTASIS AND DEATH IN PROSTATE CANCER - A RETROSPECTIVE VALIDATION STUDY
MP11-17 P-SCORE BASED ON THREE EMBRYONIC STEM CELL GENES IMPROVES PROGNOSTIC EVALUATION FOR METASTASIS AND DEATH IN PROSTATE CANCER - A RETROSPECTIVE VALIDATION STUDY Open
You have accessJournal of UrologyProstate Cancer: Staging (MP11)1 Sep 2021MP11-17 P-SCORE BASED ON THREE EMBRYONIC STEM CELL GENES IMPROVES PROGNOSTIC EVALUATION FOR METASTASIS AND DEATH IN PROSTATE CANCER - A RETROSPECTIVE VALIDATION STUD…
View article: Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis
Genome-wide identification of Wig-1 mRNA targets by RIP-Seq analysis Open
RNA-binding proteins (RBPs) play important roles in the regulation of gene expression through a variety of post-transcriptional mechanisms. The p53-induced RBP Wig-1 (Zmat3) binds RNA through its zinc finger domains and enhances stability …
View article: The p53-induced Wig-1 protein : identification of mRNA targets and role as a survival factor in development and cancer
The p53-induced Wig-1 protein : identification of mRNA targets and role as a survival factor in development and cancer Open
The tumor suppressor p53 is activated in response to a variety of stress conditions. Upon activation, p53 can trigger apoptosis or cell cycle arrest, or regulate metabolism and other cellular processes by transactivation of its targets gen…