Ana L. Flores‐Mireles
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View article: The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment
The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment Open
Urinary catheterization, a common procedure in hospitals and nursing home facilities, is a primary driver of hospital-acquired infections (HAI). These devices frequently lead to catheter-associated urinary tract infections (CAUTIs), which …
View article: Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosis
Host cysteine proteases promote the severity of catheter-associated urinary tract infection and kidney fibrosis Open
The bacterium Enterococcus faecalis is a leading cause of catheter-associated urinary tract infection (CAUTI), whose treatment is increasingly challenged by antibiotic resistance. In examining alternative therapies, we previously found tha…
View article: Role of Clot Formation and Plasminogen Activation in Lower Urinary Tract Pathologies
Role of Clot Formation and Plasminogen Activation in Lower Urinary Tract Pathologies Open
Hemostasis, a critical physiological process, is essential for stopping bleeding and initiating tissue repair after injury. It involves a tightly coordinated interplay between coagulation (blood clotting) and fibrinolysis (clot breakdown).…
View article: Characterization of a Novel Cell Wall-Associated Nucleotidase of <i>Enterococcus faecalis</i> that Degrades Extracellular c-di-AMP
Characterization of a Novel Cell Wall-Associated Nucleotidase of <i>Enterococcus faecalis</i> that Degrades Extracellular c-di-AMP Open
Enterococcus faecalis is a prolific opportunistic pathogen responsible for a range of life-threatening infections for which treatment options are increasingly limited due to the high prevalence of multidrug-resistant isolates. Cyclic di-AM…
View article: Candida auris is emerging as a prevalent urinary pathogen
Candida auris is emerging as a prevalent urinary pathogen Open
Urinary tract infections (UTIs) are one of the most common infections, with a subgroup of these infections, catheter-associated UTIs (CAUTIs), accounting for 40% of nosocomial infections. While the majority of CAUTI pathogens are bacterial…
View article: Gene therapy prevents disease and death from non-ketotic hyperglycinemia
Gene therapy prevents disease and death from non-ketotic hyperglycinemia Open
Genetic defects in glycine decarboxylase (GLDC) cause non-ketotic hyperglycinemia (NKH), a rare and frequently fatal neurometabolic disease, which lacks FDA-approved therapies. We characterized CRISPR Cas9-edited humanized mice expressing …
View article: Group a <i>Streptococcus</i> remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination
Group a <i>Streptococcus</i> remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination Open
Group A Streptococcus (GAS) is a major human pathogen that causes several invasive diseases including necrotizing fasciitis. The host coagulation cascade initiates fibrin clots to sequester bacteria to prevent dissemination into deeper tis…
View article: The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI
The catheterized bladder environment induces dysregulation of macrophage polarization exacerbating bacterial UTI Open
Urinary catheterization causes bladder damage, predisposing hosts to catheter-associated urinary tract infections (CAUTIs). CAUTI pathogenesis is mediated by bladder damage-induced inflammation, resulting in accumulation and deposition of …
View article: Effect of free liquid layer quantity on bacteria and protein adhesion to liquid infused polymers
Effect of free liquid layer quantity on bacteria and protein adhesion to liquid infused polymers Open
Liquid-infused polymers are recognized for their ability to repel foulants, making them promising for biomedical applications including catheter-associated urinary tract infections (CAUTIs). However, the impact of the quantity of free liqu…
View article: Macrophage fate: to kill or not to kill?
Macrophage fate: to kill or not to kill? Open
Macrophages are dynamic innate immune cells that either reside in tissue, serving as sentinels, or recruited as monocytes from bone marrow into inflamed and infected tissue. In response to cues in the tissue microenvironment (TME), macroph…
View article: Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI Open
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI…
View article: Blunted blades: new CRISPR-derived technologies to dissect microbial multi-drug resistance and biofilm formation
Blunted blades: new CRISPR-derived technologies to dissect microbial multi-drug resistance and biofilm formation Open
The spread of multi-drug-resistant (MDR) pathogens has rapidly outpaced the development of effective treatments. Diverse resistance mechanisms further limit the effectiveness of our best treatments, including multi-drug regimens and last l…
View article: Group A<i>Streptococcus</i>remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination
Group A<i>Streptococcus</i>remains viable inside fibrin clots and gains access to human plasminogen for subsequent fibrinolysis and dissemination Open
Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes a wide spectrum of illnesses ranging from pharyngitis and rheumatic fever to more invasive and severe diseases such as necrotizing fasciitis and toxic shock synd…
View article: Removal of Free Liquid Layer from Liquid-Infused Catheters Reduces Silicone Loss into the Environment while Maintaining Adhesion Resistance
Removal of Free Liquid Layer from Liquid-Infused Catheters Reduces Silicone Loss into the Environment while Maintaining Adhesion Resistance Open
Silicone urinary catheters infused with silicone liquid offer an effective alternative to antibiotic coatings, reducing microbial adhesion while decreasing bladder colonization and systemic dissemination. However, loss of free silicone liq…
View article: Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI.
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI. Open
Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat due to multi-drug resistance development among the CAUTI-related pathogens. Importantly, CAUTI oft…
View article: Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis
Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis Open
Cilia are essential for the ontogeny and function of many tissues, including the kidney. Here, we report that transcription factor ERRγ ortholog estrogen related receptor gamma a (Esrrγa) is essential for renal cell fate choice and cilioge…
View article: The catheterized bladder environment promotes Efg1- and Als1-dependent <i>Candida albicans</i> infection
The catheterized bladder environment promotes Efg1- and Als1-dependent <i>Candida albicans</i> infection Open
Catheter-associated urinary tract infections (CAUTIs) account for 40% of hospital-acquired infections (HAIs). As 20 to 50% of hospitalized patients receive catheters, CAUTIs are one of the most common HAIs, resulting in increased morbidity…
View article: Development and applications of a CRISPR activation system for facile genetic overexpression in <i>Candida albicans</i>
Development and applications of a CRISPR activation system for facile genetic overexpression in <i>Candida albicans</i> Open
For the fungal pathogen Candida albicans, genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with important consequences for host adaptation, virulence, and evol…
View article: Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics Open
The alarming rise of multidrug-resistant Gram-positive bacteria has precipitated a healthcare crisis, necessitating the development of new antimicrobial therapies. Here we describe a new class of antibiotics based on a ring-fused 2-pyridon…
View article: Development and applications of a CRISPR activation system for facile genetic overexpression in <i>Candida albicans</i>
Development and applications of a CRISPR activation system for facile genetic overexpression in <i>Candida albicans</i> Open
For the fungal pathogen Candida albicans , genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with important consequences for host adaptation, virulence, and evo…
View article: The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections
Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections Open
Microbial adhesion to medical devices is common for hospital-acquired infections, particularly for urinary catheters. If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter use elicit…
View article: Author response: Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections
Author response: Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Microbial adhesion to …
View article: The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence
The AdcACB/AdcAII system is essential for zinc homeostasis and an important contributor of <i>Enterococcus faecalis</i> virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: Inhibiting Host Protein Deposition on Urinary Catheters Reduces Urinary Tract Infections
Inhibiting Host Protein Deposition on Urinary Catheters Reduces Urinary Tract Infections Open
Summary Microbial adhesion to medical devices is common for hospital-acquired infections, particularly for urinary catheters. If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter us…
View article: The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of <i>Enterococcus faecalis</i> Virulence
The AdcACB/AdcAII system is Essential for Zinc Homeostasis and an Important Contributor of <i>Enterococcus faecalis</i> Virulence Open
Bacterial pathogens require a variety of micronutrients for growth, including trace metals such as iron, manganese, and zinc (Zn). Despite their relative abundance in host environments, access to these metals is severely restricted during …
View article: Esrrγa regulates nephron development and ciliogenesis by controlling prostaglandin synthesis and cooperation with Ppargc1a
Esrrγa regulates nephron development and ciliogenesis by controlling prostaglandin synthesis and cooperation with Ppargc1a Open
Cilia are essential for the ontogeny and function of many tissues, including the kidney. In mammals, Esrrγ has been previously established as a significant determinant of renal health, with decreased expression linked to age related dysfun…