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View article: Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis
Cytokine and Chemokine Profiles in Anti-LGI1 Encephalitis Open
In this study, we show that the acute-phase IL-6 CSF/serum ratio and serum IL-35 levels in immunotherapy-naive patients with anti-LGI1 encephalitis are associated with disease severity and poor outcomes, respectively, highlighting their po…
View article: Brain atrophy patterns in anti-IgLON5 disease
Brain atrophy patterns in anti-IgLON5 disease Open
Anti-IgLON5 disease is an autoimmune encephalitis that presents with a heterogenous clinical phenotype, including sleep disorders, movement abnormalities and bulbar involvement. It is characterised by autoantibodies against IgLON5, 85% ass…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (II) Open
The diagnostic performance of EUROIMMUN IIF-TBA in detecting NSAbs in autoimmune encephalitis is suboptimal. NMDAR antibodies, among the most common NSAbs, can be missed in 50% of cases. This commercial TBA should not be used alone as a sc…
View article: Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I)
Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I) Open
The performance of commercial IIF-TBAs for IC-Abs detection is suboptimal, exhibiting high false-negative rates of 25%-35%. Therefore, commercial TBAs should not be used alone for IC-Abs screening, but alongside more sensitive techniques, …
View article: ROHHAD syndrome in an adult: presence of ZSCAN1 antibodies
ROHHAD syndrome in an adult: presence of ZSCAN1 antibodies Open
Detection of ZSCAN1-abs in a ROHHAD syndrome case with an adult debut https://bit.ly/4hkcChb.
View article: Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis
Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis Open
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies an…
View article: Anti-IgLON5 Disease 10 Years Later
Anti-IgLON5 Disease 10 Years Later Open
Anti-IgLON5 disease was identified 10 years ago, thanks to the discovery of IgLON5 antibodies and the joint effort of specialists in sleep medicine, neuroimmunology, and neuropathology. Without this collaboration, it would have been imposs…
View article: Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis
Frequency, characteristics, and immunological accompaniments of ataxia in anti-NMDAR antibody-associated encephalitis Open
Introduction Very rarely, adult NMDAR antibody-associated encephalitis (NMDAR-E) leads to persistent cerebellar atrophy and ataxia. Transient cerebellar ataxia is common in pediatric NMDAR-E. Immune-mediated cerebellar ataxia may be associ…
View article: Effects of the superior mesenteric artery approach <i>versus</i> the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial
Effects of the superior mesenteric artery approach <i>versus</i> the no-touch approach during pancreatoduodenectomy on the mobilization of circulating tumour cells and clusters in pancreatic cancer (CETUPANC): randomized clinical trial Open
Background Patients with pancreatic ductal adenocarcinoma present early postoperative systemic metastases, despite complete oncological resection. The aim of this study was to assess two pancreatoduodenectomy approaches with regard to intr…
View article: B-076 Detection of KLHL11 Autoantibodies Using a New Cell-based Indirect Immunofluorescence Assay
B-076 Detection of KLHL11 Autoantibodies Using a New Cell-based Indirect Immunofluorescence Assay Open
Background Autoantibodies against kelch-like protein 11 (KLHL11) were first described in 2019 as markers of paraneoplastic encephalitis. Early diagnosis and treatment are imperative to improve prognosis and outcome of affected patients. Ra…
View article: Increased miRNA-related inflammation markers and pro-inflammatory circulating cell profile in patients with poor neurological outcome after out-of-hospital cardiac arrest
Increased miRNA-related inflammation markers and pro-inflammatory circulating cell profile in patients with poor neurological outcome after out-of-hospital cardiac arrest Open
Background Out-of-Hospital Cardiac Arrest (OHCA) supposes a main cause of disability and mortality worldwide. Between patients suffering OHCA, only a 10-20% can be successfully resuscitated and, between them, a 50% suffers of neurological …
View article: Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis
Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis Open
Anti-N-methyl- D -aspartate receptor (NMDAR) encephalitis is a disorder mediated by autoantibodies against the GluN1 subunit of NMDAR. It occurs with severe neuropsychiatric symptoms that often improve with immunotherapy. Clinical studies …
View article: Antibodies Against ZSCAN1 in Pediatric and Adult Patients With Non-Paraneoplastic ROHHAD Syndrome
Antibodies Against ZSCAN1 in Pediatric and Adult Patients With Non-Paraneoplastic ROHHAD Syndrome Open
Patients with ROHHAD syndrome should be investigated for the presence of ZSCAN1-abs in CSF. The antibodies do not necessarily predict the presence of a tumor. The detection of ZSCAN1-abs in an adult patient suggests that this condition als…
View article: HLA dependency and possible clinical relevance of intrathecally synthesized anti-IgLON5 IgG4 in anti-IgLON5 disease
HLA dependency and possible clinical relevance of intrathecally synthesized anti-IgLON5 IgG4 in anti-IgLON5 disease Open
Background Anti-IgLON5 disease is a rare chronic autoimmune disorder characterized by IgLON5 autoantibodies predominantly of the IgG4 subclass. Distinct pathogenic effects were described for anti-IgLON5 IgG1 and IgG4, however, with uncerta…
View article: New knowledge on anti-IgLON5 disease
New knowledge on anti-IgLON5 disease Open
Purpose of review Anti-IgLON5 disease is characterized by a distinctive sleep disorder, associated with a heterogeneous spectrum of neurological symptoms. Initial autopsies showed a novel neuronal tauopathy predominantly located in the teg…
View article: STEM CELL SOLUTION TO GAD65 ANTIBODIES INDUCED HURRICANE OF TYPE 1 DIABETES AND NEUROLOGICAL DISORDERS
STEM CELL SOLUTION TO GAD65 ANTIBODIES INDUCED HURRICANE OF TYPE 1 DIABETES AND NEUROLOGICAL DISORDERS Open
The encounter of disorders associated with antibodies to neuronal enzymes caused a paradigm shift in understanding the CNS autoimmunity.The autoimmune disorders targeting the 65kDa isoform of glutamic acid decarboxylase (GAD65) not only co…
View article: HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease
HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease Open
Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. The disease displays a heterogeneous phenotype that includes sleep, movement and bulbar-associated dysfunction. The presence of IgLON5-antibodies i…
View article: IgLON5 deficiency produces behavioral alterations in a knockout mouse model
IgLON5 deficiency produces behavioral alterations in a knockout mouse model Open
Background Anti-IgLON5 disease is a neurological disorder characterized by autoantibodies against IgLON5 and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule of unknown function that is highly expressed in the…
View article: mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis Open
In this study, mRNA COVID-19 vaccination was safe and did not exacerbate the autoimmune disease nor triggered neural autoantibodies or immune-mediated neurologic disorders. The outcome of patients who developed SARS-CoV-2 infection was fav…
View article: Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti-IgLON5 disease
Analysis of inflammatory markers and tau deposits in an autopsy series of nine patients with anti-IgLON5 disease Open
Anti-IgLON5 disease is a rare neurological, probably autoimmune, disorder associated in many cases with a specific tauopathy. Only a few post-mortem neuropathological studies have been reported so far. Little is known about the pathogenic …
View article: Corrigendum: Patients’ IgLON5 autoantibodies interfere with IgLON5–protein interactions
Corrigendum: Patients’ IgLON5 autoantibodies interfere with IgLON5–protein interactions Open
[This corrects the article DOI: 10.3389/fimmu.2023.1151574.].
View article: P-710 Single-cell proteomic analysis of human oocytes reveals a decreased abundance of meiosis and proteostasis regulators with advanced maternal age
P-710 Single-cell proteomic analysis of human oocytes reveals a decreased abundance of meiosis and proteostasis regulators with advanced maternal age Open
Study question How does maternal age affect the proteomic content of her oocytes during their final meiotic progression? Summary answer Compared to young oocytes, oocytes obtained from women of advanced maternal age (AMA) show a decreased …
View article: Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies
Algorithm to improve the diagnosis of paraneoplastic neurological syndromes associated with SOX1 antibodies Open
SOX1 antibodies (SOX1-abs) are associated with paraneoplastic neurological syndromes (PNS) and small cell lung cancer (SCLC). In many clinical laboratories SOX1-abs are determined by commercial line blots without confirmation by cell-based…
View article: Patients’ IgLON5 autoantibodies interfere with IgLON5-protein interactions
Patients’ IgLON5 autoantibodies interfere with IgLON5-protein interactions Open
Background Anti-IgLON5 disease is a rare neurological disorder characterized by autoantibodies against IgLON5, and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule but its physiological function is unknown. Ou…
View article: Anti‐kelchlike protein 11 antibody‐associated encephalitis: Two case reports and review of the literature
Anti‐kelchlike protein 11 antibody‐associated encephalitis: Two case reports and review of the literature Open
Background and purpose Kelchlike protein 11 antibodies (KLHL11‐IgGs) were first described in 2019 as a marker of paraneoplastic neurological syndromes (PNSs). They have mostly been associated with testicular germ cell tumors (tGCTs). Metho…
View article: The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined
The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined Open
Detection of Leucine-rich glioma inactivated 1 (LGI1) antibodies in patients with suspected autoimmune encephalitis is important for diagnostic confirmation and prompt implementation of immunomodulatory treatment. However, the clinical lab…