Lidia Sambucetti YOU? Author Swipe

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1345P Preclinical activity of ORIC-114, a highly selective, brain penetrant, irreversible kinase inhibitor, against atypical mutations in EGFR Open

Melissa R. Junttila, Richard Warne, Claire E. Repellin, Lidia Sambucetti, Jianjun Chang , et al. · 2023

Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2022

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2021

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2021

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2021

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2021

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

New structural insights into the function of the catalytically active human Taspase1 Open

José M. Martín-García, Nirupa Nagaratnam, S.L. Delker, Rebecca Jernigan, Thomas E. Edwards , et al. · 2021

Taspase1 is an Ntn-hydrolase overexpressed in primary human cancers, coordinating cancer 33Tcell proliferation, invasion, and metastasis.L33Toss of Taspase1 activity disrupts proliferation of human cancer cells in vitro and in mouse models…

Structural insights into the function of the catalytically active human Taspase1 Open

Nirupa Nagaratnam, S.L. Delker, Rebecca Jernigan, Thomas E. Edwards, Janey Snider , et al. · 2021

New Structural Insights into the Function of the Catalytically Active Human Taspase1 Open

Nirupa Nagaratnam, S.L. Delker, Rebecca Jernigan, Thomas E. Edwards, Janey Snider , et al. · 2020

Proteases can play essential roles in severe human pathology, ranging from degenerative and inflammatory illnesses to infectious diseases, with some, such as Taspase1, involved in growth and progression of tumors at primary and metastatic …

The metal-responsive transcription factor-1 protein is elevated in human tumors Open

Yihui Shi, Khalid Amin, Barbara Sato, Steven J. Samuelsson, Lidia Sambucetti , et al. · 2020

We previously identified metal-responsive transcription factor-1 (MTF-1) as a positive contributor to mouse fibrosarcoma growth through effects on cell survival, proliferation, tumor angiogenesis and extracellular matrix remodeling. In the…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2020

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers Open

Michal Avital‐Shmilovici, Xiaohe Liu, Thomas A. Shaler, Andrew Lowenthal, Pauline Bourbon , et al. · 2020

Combinatorial methods enable the synthesis of chemical libraries on scales of millions to billions of compounds, but the ability to efficiently screen and sequence such large libraries has remained a major bottleneck for molecular discover…

An exon skipping screen identifies antitumor drugs that are potent modulators of pre-mRNA splicing, suggesting new therapeutic applications Open

Yihui Shi, Walter M. Bray, Alexander J. Smith, Wei Zhou, Joy M. Calaoagan , et al. · 2020

Agents that modulate pre-mRNA splicing are of interest in multiple therapeutic areas, including cancer. We report our recent screening results with the application of a cell-based Triple Exon Skipping Luciferase Reporter (TESLR) using a li…

New Structural Insights into the Function of the Active Full Length Human Taspase1: A Novel Anticancer Therapeutic Target Open

Rebecca Jernigan, Nirupa Nagaratnam, Darren Thifault, S.L. Delker, Michele A. Zacks , et al. · 2020

Engineered Ovarian Cancer Cell Lines for Validation of CAR T Cell Function Open

Claire E. Repellin, Priya Ganesan, Javier F. Alcudia, Haritha K. Duggireddy Lakshmireddy, Puja Patel , et al. · 2019

A set of genetically engineered isogenic cell lines is developed to express either folate receptor alpha or mesothelin, and a control cell line negative for both antigens. These cell lines also express fluorescent and bioluminescent report…

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore Open

Yihui Shi, Jae Won Park, Chandraiah Lagisetti, Wei Zhou, Lidia Sambucetti , et al. · 2016

A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models Open

Benjamin Spangler, Shaun D. Fontaine, Yihui Shi, Lidia Sambucetti, Aras N. Mattis , et al. · 2016

Here we describe a new approach for tumor targeting in which augmented concentrations of Fe(II) in cancer cells and/or the tumor microenvironment triggers drug release from an Fe(II)-reactive prodrug conjugate. The 1,2,4-trioxolane scaffol…

A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy Open

Laura K. DeMaster, Xiaohe Liu, Jake VanBelzen, Benjamin Trinité, Lingjie Zheng , et al. · 2015

A major goal in HIV eradication research is characterizing the reservoir cells that harbor HIV in the presence of antiretroviral therapy (ART), which reseed viremia after treatment is stopped. In general, it is assumed that the reservoir c…

Exploring Glycan Markers for Immunotyping and Precision-targeting of Breast Circulating Tumor Cells Open

Guoyin Wang, Xiaohe Liu, B. R. Hsieh, Richard Bruce, George Somlo , et al. · 2015

Pharmacodynamic assays to facilitate preclinical and clinical development of pre‐<span>mRNA</span> splicing modulatory drug candidates Open

Yihui Shi, Amanda S. Joyner, William R. Shadrick, Gustavo Palacios, Chandraiah Lagisetti , et al. · 2015

The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel pharmacodynamic assays that facilitate drug discovery …

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