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View article: Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing
Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing Open
Aptamers are highly selective nucleic acid ligands that overcome many challenges of antibodies, including structural instability and high production costs. The implementation of aptamers into routine research and commercial applications ha…
View article: PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells
PiP‐Plex: A Particle‐in‐Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells Open
Cell signaling is modulated by the secretion of various proteins, which can be used to infer a cell's phenotype. However, these proteins cannot be readily detected in multiplex by commonly used methods at the single‐cell level. Here we pre…
View article: A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis
A machine learning and centrifugal microfluidics platform for bedside prediction of sepsis Open
Sepsis is a life-threatening organ dysfunction due to a dysfunctional response to infection. Delays in diagnosis have substantial impact on survival. Herein, blood samples from 586 in-house patients with suspected sepsis are used in conjun…
View article: PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells
PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Proteins Secreted by Single Cells Open
Cell signaling is modulated by the secretion of various proteins, which can be used to infer a cell’s phenotype. However, these proteins cannot be readily detected in multiplex by commonly used methods at the single cell level. Here, we pr…
View article: Microfluidic Integration of Magnetically Functionalized Microwires for Flow Cytometry Protein Quantification
Microfluidic Integration of Magnetically Functionalized Microwires for Flow Cytometry Protein Quantification Open
A novel approach to protein quantification utilizing a microfluidic platform activated by a magnetic assembly of functionalized magnetic beads around soft magnetic capture centers is presented. Functionalized magnetic beads, known for thei…
View article: A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva
A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva Open
This study presents an automated digital microfluidic platform capable of simultaneously detecting SARS-CoV-2 infection (spike protein) and immune response markers (IgG and IgA) in saliva with high sensitivity and specificity.
View article: Using machine learning and centrifugal microfluidics at the point-of-need to predict clinical deterioration of patients with suspected sepsis within the first 24 h.
Using machine learning and centrifugal microfluidics at the point-of-need to predict clinical deterioration of patients with suspected sepsis within the first 24 h. Open
Sepsis is the bodys dysfunctional response to infection associated with organ failure. Delays in diagnosis have a substantial impact on survival. Herein, samples from 586 in-house patients were used in conjunction with machine learning and…
View article: Microfluidic methods for the diagnosis of acute respiratory tract infections
Microfluidic methods for the diagnosis of acute respiratory tract infections Open
We review emerging methods for the detection of acute respiratory tract infections using microfluidic technologies.
View article: Centrifugal microfluidic system for colorimetric sample-to-answer detection of viral pathogens
Centrifugal microfluidic system for colorimetric sample-to-answer detection of viral pathogens Open
Automated on-chip sample-to-answer workflow for multiplexed colorimetric detection of foodborne viruses using an embedded polymer micropillar array for read-out.
View article: Reversible bonding in thermoplastic elastomer microfluidic platforms for harvestable 3D microvessel networks
Reversible bonding in thermoplastic elastomer microfluidic platforms for harvestable 3D microvessel networks Open
An openable, reversibly bonded microfluidic cell culture platform fabricated in thermoplastic elastomer and polystyrene for the generation, recovery, and extraction of engineered-microvessel networks.
View article: Sample-to-answer centrifugal microfluidic droplet PCR platform for quantitation of viral load
Sample-to-answer centrifugal microfluidic droplet PCR platform for quantitation of viral load Open
Fully automated sample-to-answer ddPCR for virus quantification is implemented on a centrifugal platform with active pneumatic pumping comprising wireless heaters and miniaturized fluorescence imaging system.