Liding Zhao
YOU?
Author Swipe
View article: SLC7A11 is an unconventional H+ transporter in lysosomes
SLC7A11 is an unconventional H+ transporter in lysosomes Open
Lysosomes maintain an acidic pH of 4.5-5.0, optimal for macromolecular degradation. Whereas proton influx is produced by a V-type H+ ATPase, proton efflux is mediated by a fast H+ leak through TMEM175 channels, as wel…
View article: Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress
Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress Open
Elevated levels of plasma-free fatty acids and oxidative stress have been identified as putative primary pathogenic factors in endothelial dysfunction etiology, though their roles are unclear. In human endothelial cells, we found that satu…
View article: Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart
Proline metabolic reprogramming modulates cardiac remodeling induced by pressure overload in the heart Open
Metabolic reprogramming is critical in the onset of pressure overload–induced cardiac remodeling. Our study reveals that proline dehydrogenase (PRODH), the key enzyme in proline metabolism, reprograms cardiomyocyte metabolism to protect ag…
View article: Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling
Cypher/ZASP drives cardiomyocyte maturation via actin-mediated MRTFA-SRF signalling Open
Rationale: Cardiomyocytes (CMs) undergo dramatic structural and functional changes in postnatal maturation; however, the regulatory mechanisms remain greatly unclear. Cypher/Z-band alternatively spliced PDZ-motif protein (ZASP) is a…
View article: Association Between Contrast Volume-to-Creatinine Clearance Ratio and the Risk of Perioperative Myocardial Infarction After Elective Percutaneous Coronary Intervention
Association Between Contrast Volume-to-Creatinine Clearance Ratio and the Risk of Perioperative Myocardial Infarction After Elective Percutaneous Coronary Intervention Open
Although the use of iodinated contrast for percutaneous coronary intervention (PCI) has known toxicity issues, the association between the contrast volume-to-creatinine clearance (V/CrCl) ratio and perioperative myocardial infarction (PMI)…
View article: Prognostic significance of troponin increment after percutaneous coronary intervention: A retrospective study
Prognostic significance of troponin increment after percutaneous coronary intervention: A retrospective study Open
Objective The prognostic significance of troponin elevation following percutaneous coronary intervention (PCI) remains debated. This study aimed to evaluate the association between different thresholds of post-PCI cardiac troponin I (cTnI)…
View article: Mitochondrial dysfunction in heart failure and its therapeutic implications
Mitochondrial dysfunction in heart failure and its therapeutic implications Open
The ATP consumption in heart is very intensive to support muscle contraction and relaxation. Mitochondrion is the power plant of the cell. Mitochondrial dysfunction has long been believed as the primary mechanism responsible for the inabil…
View article: Gensini score values for predicting periprocedural myocardial infarction: An observational study analysis
Gensini score values for predicting periprocedural myocardial infarction: An observational study analysis Open
The Gensini score (GS) is a convenient, powerful tool for assessing the severity and complexity of coronary artery diseases. Our research investigated the relationship between the GS and periprocedural myocardial infarction (PMI). We recru…
View article: Admission electrolyte and osmotic pressure levels are associated with the incidence of contrast-associated acute kidney injury
Admission electrolyte and osmotic pressure levels are associated with the incidence of contrast-associated acute kidney injury Open
View article: Systemic Immune-Inflammation Index Predicts Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Cross-Sectional Study
Systemic Immune-Inflammation Index Predicts Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Cross-Sectional Study Open
Background and Aims Systemic immune-inflammation index (SII) is an emerging indicator and correlated to the incidence of cardiovascular diseases. This study aimed to explore the association between SII and contrast-induced acute kidney inj…
View article: Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention
Effects of bilirubin on perioperative myocardial infarction and its long-term prognosis in patients undergoing percutaneous coronary intervention Open
Bilirubin was a protective factor in PMI prediction. For post-PMI patients, elevated bilirubin levels were independently associated with a reduced risk of MACEs during long-term follow-up.
View article: Elevation of Hemoglobin A1c Increases the Atherosclerotic Plaque Vulnerability and the Visit-to-Visit Variability of Lipid Profiles in Patients Who Underwent Elective Percutaneous Coronary Intervention
Elevation of Hemoglobin A1c Increases the Atherosclerotic Plaque Vulnerability and the Visit-to-Visit Variability of Lipid Profiles in Patients Who Underwent Elective Percutaneous Coronary Intervention Open
Background Increased plaque vulnerability and higher lipid variability are causes of adverse cardiovascular events. Despite a close association between glucose and lipid metabolisms, the influence of elevated glycated hemoglobin A1c (HbA1c…
View article: Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ1 signaling pathway in diabetic atherosclerosis
Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKCβ1 signaling pathway in diabetic atherosclerosis Open
View article: [Corrigendum] Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF‑κB/c‑fos signaling pathway
[Corrigendum] Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF‑κB/c‑fos signaling pathway Open
[This corrects the article DOI: 10.3892/etm.2019.8312.].
View article: Association of the classification and severity of heart failure with the incidence of contrast-induced acute kidney injury
Association of the classification and severity of heart failure with the incidence of contrast-induced acute kidney injury Open
Congestive heart failure (HF) is a known risk factor of contrast-induced acute kidney injury (CI-AKI). However, the relationship of the classification and severity of HF with CI-AKI remains under-explored. From January 2009 to April 2019, …
View article: β-blocker use before elective percutaneous coronary intervention as a risk factor for periprocedural myocardial injury incidence in male patients below 75 years old: a single-center retrospective study
β-blocker use before elective percutaneous coronary intervention as a risk factor for periprocedural myocardial injury incidence in male patients below 75 years old: a single-center retrospective study Open
Our study indicates that the PCI-PMI association depends on age and gender groups, β-blocker use before PCI is associated with increased PMI incidence in male patients <75 years old.
View article: Predictors of recurrent angina in patients with no need for secondary revascularization
Predictors of recurrent angina in patients with no need for secondary revascularization Open
Patient characteristics of female sex, older age, diabetes, and elevated BMI are associated with an increased TIMI frame count, coronary microcirculation dysfunction, and recurrent angina pectoris after initially successful PCI. In additio…
View article: Hemoglobin A1c Levels Affect Visit-to-visit Variability of Lipid Profiles in Patients Undergoing Elective Percutaneous Coronary Intervention: A Retrospective Study
Hemoglobin A1c Levels Affect Visit-to-visit Variability of Lipid Profiles in Patients Undergoing Elective Percutaneous Coronary Intervention: A Retrospective Study Open
BackgroundBoth hemoglobin A1c (HbA1c) levels and visit-to-visit variability of lipid profiles are risk factors for cardiovascular disease (CVD). We conducted a retrospective cohort study to explore the relationship between HbA1c and lipid …
View article: Impact of increased inflammation biomarkers on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention: a cohort study
Impact of increased inflammation biomarkers on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention: a cohort study Open
In patients with elective PCI for single-vessel lesions, high CRP increases the risk for PMI. The increase of NLR was an independent risk factor for PMI, especially for patients with hypertension and under the age of 70. WBC has no influen…
View article: Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: a retrospective study
Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: a retrospective study Open
Background Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. Ho…
View article: Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: A retrospective study
Variability in blood lipids affects the neutrophil to lymphocyte ratio in patients undergoing elective percutaneous coronary intervention: A retrospective study Open
Background: Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. H…
View article: Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKC<i>β</i>1-IRS1-NF-<i>κ</i>B Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in Diabetes
Insulin-Attenuated Inflammatory Response of Dendritic Cells in Diabetes by Regulating RAGE-PKC<i>β</i>1-IRS1-NF-<i>κ</i>B Signal Pathway: A Study on the Anti-Inflammatory Mechanism of Insulin in Diabetes Open
Background . Diabetes is associated with chronic inflammation, and dendritic cells (DCs) have proinflammatory effect in diabetes. The anti-inflammatory effect of insulin on diabetes is not entirely clear. The study aims to examine insulin-…
View article: Rosuvastatin Reverses Hypertension-Induced Changes in the Aorta Structure and Endothelium-Dependent Relaxation in Rats Through Suppression of Apoptosis and Inflammation
Rosuvastatin Reverses Hypertension-Induced Changes in the Aorta Structure and Endothelium-Dependent Relaxation in Rats Through Suppression of Apoptosis and Inflammation Open
Vascular remodeling is one of the most critical complications caused by hypertension. Previous studies have demonstrated that rosuvastatin has anti-inflammatory, antioxidant, and antiplatelet effects and therefore can be used to treat card…
View article: Primary prevention of myocardial infarction: aspirin is not as useful as it seems
Primary prevention of myocardial infarction: aspirin is not as useful as it seems Open
Aspirin may not provide a primary preventive effect in all myocardial infarction patients. Previously demonstrated reductions in myocardial infarction are not present when SMI is included.
View article: Variability in blood lipid affects the neutrophil to lymphocyte ratio in patients who have undergone elective percutaneous coronary intervention: A retrospective study
Variability in blood lipid affects the neutrophil to lymphocyte ratio in patients who have undergone elective percutaneous coronary intervention: A retrospective study Open
Background Atherosclerosis is associated with chronic inflammation and lipid metabolism. The neutrophil to lymphocyte ratio (NLR) as an indicator of inflammation has been confirmed to be associated with cardiovascular disease prognosis. Ho…
View article: Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF‑κB/c‑fos signaling pathway
Metoprolol and bisoprolol ameliorate hypertrophy of neonatal rat cardiomyocytes induced by high glucose via the PKC/NF‑κB/c‑fos signaling pathway Open
Hyperglycemia caused by diabetes mellitus could increase the risk of diabetic cardiomyopathy. However, to the best of our knowledge, the underlying mechanism of this process is still not fully explored. Thus, developing ways to prevent hyp…
View article: Comparison of Machine Learning Models and Framingham Risk Score for the prediction of the presence and severity of Coronary Artery Diseases by using Gensini Score
Comparison of Machine Learning Models and Framingham Risk Score for the prediction of the presence and severity of Coronary Artery Diseases by using Gensini Score Open
Background: The risk prediction model for cardiovascular conditions based on the routine information isn’t established. Machine Learning (ML) models offered opportunities to build a promising and accurate prediction system for the presence…