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View article: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation
IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation Open
The ability of most patients with selective immunoglobulin A (IgA) deficiency (SIgAD) to remain apparently healthy has been a persistent clinical conundrum. Compensatory mechanisms, including IgM, have been proposed, yet it remains unclear…
View article: Arresting microbiome development limits immune system maturation and resistance to infection in mice
Arresting microbiome development limits immune system maturation and resistance to infection in mice Open
View article: Arresting microbiome development limits immune system maturation and resistance to infection
Arresting microbiome development limits immune system maturation and resistance to infection Open
Disruptions to the intestinal microbiome during weaning lead to long-term negative effects on host immune function. However, the critical host-microbe interactions occurring during weaning required for healthy immune system development rem…
View article: SARS-CoV-2 variants associated with vaccine breakthrough in the Delaware Valley through summer 2021
SARS-CoV-2 variants associated with vaccine breakthrough in the Delaware Valley through summer 2021 Open
The severe acute respiratory coronavirus-2 (SARS-CoV-2) is the cause of the global outbreak of COVID-19. Evidence suggests that the virus is evolving to allow efficient spread through the human population, including vaccinated individuals.…
View article: IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation
IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation Open
Summary Mammals produce large quantities of mucosal and systemic antibodies that maintain the intestinal barrier, shape the intestinal microbiome and promote lifelong mutualism with commensal microbes. Here, we developed an integrated host…
View article: Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 isolates from Pennsylvania Open
Rapid whole genome sequencing of SARS-CoV-2 has presented the ability to detect new emerging variants of concern in near real time. Here we report the genome of a virus isolated in Pennsylvania in March 2021 that was identified as lineage …
View article: Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans
Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans Open
Supporting data for publication. Raw Trees for Figure 1 and supplementary figures 2 and 3. Roary presence absence output.
View article: Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans
Trees and Roary output for Adaptation by ancient horizontal acquisition of butyrate metabolism genes in Aggregatibacter actinomycetemcomitans Open
Supporting data for publication. Raw Trees for Figure 1 and supplementary figures 2 and 3. Roary presence absence output.
View article: IgA deficiency Alters Systemic Immune Response to Commensal Gut Microbes
IgA deficiency Alters Systemic Immune Response to Commensal Gut Microbes Open