Lidwien M. Hanff
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View article: Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review
Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review Open
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome furthe…
View article: Nephrotoxicity and kidney outcomes in pediatric oncology patients
Nephrotoxicity and kidney outcomes in pediatric oncology patients Open
Background Acute kidney injury (AKI) is a serious complication during pediatric cancer treatment. Nephrotoxic medication may increase the risk of developing AKI, which may necessitate modifications to standard treatment and may also increa…
View article: Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects
Implementing Pre‐Emptive Pharmacogenetics: Impact of Early Pharmacogenetic Screening in a Pediatric Oncology Cohort of 1,151 Subjects Open
In pediatric oncology, pharmacogenetic guidelines are underutilized and the potential impact of pre‐emptive pharmacogenetic screening remains largely unexplored despite this field's need for individualized approaches. While comprehensive p…
View article: Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms
Practical Recommendations for the Manipulation of Kinase Inhibitor Formulations to Age-Appropriate Dosage Forms Open
Over 75 kinase inhibitors (KIs) have been approved for the treatment of various cancers. KIs are orally administrated but mostly lack pediatric age-appropriate dosage forms or instructions for dose manipulation. This is highly problematic …
View article: Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice
Editorial: Therapeutic Drug Monitoring (TDM): A Useful Tool for Pediatric Pharmacology Applied to Routine Clinical Practice Open
EDITORIAL article Front. Pharmacol., 24 May 2022Sec. Obstetric and Pediatric Pharmacology https://doi.org/10.3389/fphar.2022.931843
View article: A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children
A simple extemporaneous oral suspension of aprepitant yields sufficient pharmacokinetic exposure in children Open
Introduction Aprepitant is used for the treatment of chemotherapy induced nausea and vomiting. A liquid formulation is needed for treatment of young children. However, the commercial (powder for) suspension was not available worldwide for …
View article: Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population
Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population Open
This review describes acetaminophen pharmacokinetics (PK) throughout pregnancy, as analyzed by three methods (non-compartmental analyses (NCA), population PK, and physiologically based PK (PBPK) modelling). Eighteen studies using NCA were …
View article: Supplementation of vitamins, trace elements and electrolytes in the PEPaNIC Randomised Controlled Trial: Composition and preparation of the prescription
Supplementation of vitamins, trace elements and electrolytes in the PEPaNIC Randomised Controlled Trial: Composition and preparation of the prescription Open
View article: Pharmacogenomics as a Tool to Limit Acute and Long-Term Adverse Effects of Chemotherapeutics: An Update in Pediatric Oncology
Pharmacogenomics as a Tool to Limit Acute and Long-Term Adverse Effects of Chemotherapeutics: An Update in Pediatric Oncology Open
In the past decades, new cancer treatments have been introduced in pediatric oncology leading to improvement in clinical outcomes and survival rates. However, due to inter-individual differences, some children experience severe chemotherap…
View article: Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology
Pharmacokinetic Targets for Therapeutic Drug Monitoring of Small Molecule Kinase Inhibitors in Pediatric Oncology Open
In recent years new targeted small molecule kinase inhibitors have become available for pediatric patients with cancer. Relationships between drug exposure and treatment response have been established for several of these drugs in adults. …
View article: Availability of age-appropriate paediatric formulations in the Netherlands: the need in daily clinical practice remains
Availability of age-appropriate paediatric formulations in the Netherlands: the need in daily clinical practice remains Open
This study confirms there is still a large need for age-appropriate formulations in daily clinical practice. Pharmacy compounding for paediatric patients remains essential for many indications. The need for potentially harmful excipients i…
View article: P68 Significant oral drug use in critically ill children: rational therapy or a black box?
P68 Significant oral drug use in critically ill children: rational therapy or a black box? Open
Background The disposition of orally prescribed drugs in critically ill children may be affected critical illness in in addition to age, resulting in erratic effects and safety. We aimed to study oral drug prescribing in the neonatal and p…
View article: Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam
Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam Open
Aims This study explores the impact of paediatric patient related factors and choice of formulation on the dissolution characteristics of nifedipine and lorazepam, 2 drug substances regularly applied in very young patients and in compounde…
View article: Manipulation of oral medication for children by parents and nurses occurs frequently and is often not supported by instructions
Manipulation of oral medication for children by parents and nurses occurs frequently and is often not supported by instructions Open
Aim Due to a lack of age‐appropriate formulations, administration of drugs to children remains a challenge. This study aimed to identify the problems experienced in both the outpatient setting and the clinical setting. Methods Between June…
View article: Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients
Impact of dose adaptations following voriconazole therapeutic drug monitoring in pediatric patients Open
Voriconazole is the mainstay of treatment for invasive aspergillosis in immunocompromised pediatric patients. Although Therapeutic Drug Monitoring (TDM) of voriconazole is recommended, it remains unknown if TDM-based dose adaptations resul…
View article: Oral lorazepam can be substituted for intravenous midazolam when weaning paediatric intensive care patients off sedation
Oral lorazepam can be substituted for intravenous midazolam when weaning paediatric intensive care patients off sedation Open
Aim Intravenous sedatives used in the paediatric intensive care unit (PICU) need to be tapered after prolonged use to prevent iatrogenic withdrawal syndrome (IWS). We evaluated the occurrence of IWS and the levels of sedation before and af…
View article: Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients; lorazepam as a model drug
Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients; lorazepam as a model drug Open
An organic solvent based oral formulation was shown to be superior to a non-ionic surfactant based formulation or a cyclodextrin formulation. These results may help to formulate paediatric formulations of other poorly water soluble drugs, …
View article: Insufficient Sedation and Severe Side Effects after Fast Administration of Remifentanil during INSURE in Preterm Newborns
Insufficient Sedation and Severe Side Effects after Fast Administration of Remifentanil during INSURE in Preterm Newborns Open
Background: Neonatal intubation is stressful and should be performed with premedication. In the case of an INSURE (intubation/surfactant/extubation) procedure a short duration of action of the premedication used is needed to …
View article: Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study
Necrotising enterocolitis and mortality in preterm infants after introduction of probiotics: a quasi-experimental study Open
Evidence on the clinical effectiveness of probiotics in the prevention of necrotising enterocolitis (NEC) in preterm infants is conflicting and cohort studies lacked adjustment for time trend and feeding type. This study investigated the a…
View article: Doxazosin treatment of phaeochromocytoma during pregnancy: placental transfer and disposition in breast milk
Doxazosin treatment of phaeochromocytoma during pregnancy: placental transfer and disposition in breast milk Open
Information on transfer of drugs and metabolites into placental blood and breast milk is based on modelling, animal experiments and clinical observations due to lack of experimental evidence in humans. We describe the use of doxazosin in a…
View article: Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films
Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films Open
Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics para…